Effects of oxytocin on recollections of maternal care and closeness

Although the infant–caregiver attachment bond is critical to survival, little is known about the biological mechanisms supporting attachment representations in humans. Oxytocin plays a key role in attachment bond formation and maintenance in animals and thus could be expected to affect attachment representations in humans. To investigate this possibility, we administered 24 IU intranasal oxytocin to healthy male adults in a double-blind, placebo-controlled, crossover designed study and then assessed memories of childhood maternal care and closeness—two features of the attachment bond. We found that the effects of oxytocin were moderated by the attachment representations people possess, with less anxiously attached individuals remembering their mother as more caring and close after oxytocin (vs. placebo) but more anxiously attached individuals remembering their mother as less caring and close after oxytocin (vs. placebo). These data contrast with the popular notion that oxytocin has broad positive effects on social perception and are more consistent with the animal literature, which emphasizes oxytocin's role in encoding social memories and linking those memories to the reward value of the social stimulus.

[1]  G. Parker,et al.  The parental bonding instrument , 1979, Social Psychiatry and Psychiatric Epidemiology.

[2]  K. Bartholomew,et al.  Attachment styles among young adults: a test of a four-category model. , 1991, Journal of personality and social psychology.

[3]  Larry J. Young,et al.  Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior , 2009, Frontiers in Neuroendocrinology.

[4]  Phillip R. Shaver,et al.  The Attachment Behavioral System in Adulthood: Activation, Psychodynamics, and Interpersonal Processes. , 2003 .

[5]  J. Lydon,et al.  Global and specific relational models in the experience of social interactions. , 2001, Journal of personality and social psychology.

[6]  L. Young,et al.  CHAPTER 58 – Oxytocin: Synthesis, Secretion, and Reproductive Functions , 2006 .

[7]  J. Metcalfe,et al.  A hot/cool-system analysis of delay of gratification: dynamics of willpower. , 1999, Psychological review.

[8]  G. Parker,et al.  The stability of the Parental Bonding Instrument over a 20-year period , 2004, Psychological Medicine.

[9]  Peter Klaver,et al.  Oxytocin Makes a Face in Memory Familiar , 2009, The Journal of Neuroscience.

[10]  T. Kitamura,et al.  Factorial Structure of the Parental Bonding Instrument (PBI) in Japan: A Study of Cultural, Developmental, and Gender Influences , 2006, Child psychiatry and human development.

[11]  Carol Carter Porges.  Neuroendocrine perspectives on social attachment and love , 1998 .

[12]  U. Fischbacher,et al.  Oxytocin increases trust in humans , 2005, Nature.

[13]  R. Chris Fraley,et al.  Attachment Stability From Infancy to Adulthood: Meta-Analysis and Dynamic Modeling of Developmental Mechanisms , 2002 .

[14]  Philip B. Mitchell,et al.  Oxytocin Enhances the Encoding of Positive Social Memories in Humans , 2008, Biological Psychiatry.

[15]  G. Fletcher,et al.  Mapping the Intimate Relationship Mind: Comparisons between Three Models of Attachment Representations , 2003, Personality & social psychology bulletin.

[16]  Ross A. Thompson,et al.  Early sociopersonality development. , 1998 .

[17]  J. Bowlby,et al.  Attachment and Loss, Volume I: Attachment , 1970 .

[18]  T. Insel,et al.  The neurobiology of attachment , 2001, Nature Reviews Neuroscience.

[19]  Martin A. Safer,et al.  Sources of Bias in Memory for Emotions , 2002 .

[20]  J. Panksepp.  Oxytocin Effects on Emotional Processes: Separation Distress, Social Bonding, and Relationships to Psychiatric Disorders , 1992, Annals of the New York Academy of Sciences.

[21]  P. Shaver,et al.  Adult attachment and the suppression of unwanted thoughts. , 1997, Journal of personality and social psychology.

[22]  E. Hollander,et al.  The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior , 2006, Hormones and Behavior.

[23]  G. Parker,et al.  The Parental Bonding Instrument: psychometric properties reviewed. , 1989, Psychiatric developments.

[24]  T. Insel.  Is social attachment an addictive disorder? , 2003, Physiology & Behavior.

[25]  J. D. Neill,et al.  Knobil and Neill's Physiology of reproduction , 2006 .

[26]  P. Zak,et al.  Oxytocin Increases Generosity in Humans , 2007, PloS one.

[27]  Z. Kunda,et al.  The case for motivated reasoning. , 1990, Psychological bulletin.

[28]  Jamil Zaki,et al.  Oxytocin Selectively Improves Empathic Accuracy , 2010, Psychological science.

[29]  M. Rosenberg.  Society and the adolescent self-image , 1966 .

[30]  P. Shaver,et al.  Attachment in Adulthood: Structure, Dynamics, and Change , 2007 .

[31]  A. Schulz,et al.  Post-learning intranasal oxytocin modulates human memory for facial identity , 2008, Psychoneuroendocrinology.

[32]  David M. Sanbonmatsu,et al.  On the automatic activation of attitudes. , 1986, Journal of personality and social psychology.

[33]  P. Zak,et al.  Oxytocin is associated with human trustworthiness , 2005, Hormones and Behavior.

[34]  A. Aron,et al.  Close Relationships as Including Other in the Self , 1991 .

[35]  G. Downey,et al.  Attentional Mechanisms Linking Rejection to Hostile Reactivity: The Role of “Hot” Versus “Cool” Focus , 2002, Psychological science.

[36]  R. C. Fraley,et al.  Attachment and Loss , 2018 .

[37]  Kelly A. Brennan,et al.  Self-report measurement of adult attachment: An integrative overview. , 1998 .