[Hydraulic conductivity of the visceral pleura with hemodynamic lung edema in dogs].

Hydraulic conductivity of the visceral pleura was measured in situ in anesthetized dogs. There were two groups: control (n = 7), and edema (n = 5). The 7th intercostal space of the left thorax was opened. In each group, a hemispherical capsule, filled with physiological salt solution, was attached to the visceral pleura of left lobe by negative pressure made with a vacuum pump. In the edema group, pulmonary venous pressure was increased by ligation of the pulmonary vein. The transpleural fluid flow (V) was measured at different intracapsular pressures (delta P). The hydraulic conductivity was calculated from the relation between the fluid flow rate (v) and the intracapsular pressure, i.e., the slope of the linear regression line. The hydraulic conductivities in the control and edema groups were 1.49 +/- 0.68 and 3.19 +/- 1.13 nL.min-1.cmH2O-1.cm-2, respectively. We conclude that the pleural tissue may play an important role in hydraulic conductivity of the visceral pleura when pulmonary venous pressure is high.

[1]  R. Filly,et al.  Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. , 2015, The American review of respiratory disease.

[2]  Y. Kawashima,et al.  Dynamic insufficiency of lung lymph flow from the right lymph duct in dogs with acute filtration edema. , 2015, The American review of respiratory disease.

[3]  E. Crandall,et al.  Transport of water and solutes across sheep visceral pleura. , 2015, The American review of respiratory disease.

[4]  G. Miserocchi,et al.  Model of pleural fluid turnover. , 1993, Journal of applied physiology.

[5]  G. Miserocchi,et al.  Pulmonary interstitial pressure in intact in situ lung: transition to interstitial edema. , 1993, Journal of applied physiology.

[6]  S. Yamada,et al.  Plasma protein osmotic pressure equations and nomogram for sheep. , 1991, Journal of applied physiology.

[7]  G. Miserocchi,et al.  Pleural Lymphatics as Regulators of Pleural Fluid Dynamics , 1991 .

[8]  A. Taylor,et al.  Hydraulic conductivity of canine parietal pleura in vivo. , 1990, Journal of applied physiology.

[9]  J. Wiener-Kronish,et al.  Clearance of lung edema into the pleural space of volume-loaded anesthetized sheep. , 1990, Journal of applied physiology.

[10]  M. Pistolesi,et al.  Pleural liquid and solute exchange. , 1989, The American review of respiratory disease.

[11]  R. Drake,et al.  Left atrial hypertension causes pleural effusion formation in unanesthetized sheep. , 1989, The American journal of physiology.

[12]  K. Albertine,et al.  Pleural effusions and pulmonary edema. , 1985, Clinics in chest medicine.

[13]  G. Miserocchi,et al.  Regional protein absorption rates from the pleural cavity in dogs. , 1985, Journal of applied physiology.

[14]  N. Staub,et al.  Interstitial fluid pressure gradient measured by micropuncture in excised dog lung. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[15]  T. Ohnuki,et al.  Quantitative assessment of water content of human lung: a study on open lung biopsy specimen. , 1982, The Tohoku journal of experimental medicine.

[16]  A. Fishman,et al.  Influence of alterations in Starling forces on visceral pleural fluid movement. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[17]  H. Granger,et al.  Permeability of Connective Tissue Linings Isolated from Implanted Capsules: IMPLICATIONS FOR INTERSTITIAL PRESSURE MEASUREMENTS , 1975, Circulation research.

[18]  R. Mellins,et al.  Fluid filtration in the lung of the intact puppy. , 1973, Journal of applied physiology.

[19]  I. Setnikar,et al.  Absorption force of the capillaries of the visceral pleura in determination of the intrapleural pressure. , 1957, The American journal of physiology.