Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators.

[1]  H. Lester,et al.  Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum* , 2014, The Journal of Biological Chemistry.

[2]  W. Joiner,et al.  SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission , 2014, Current Biology.

[3]  H. Sunaga,et al.  SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity , 2014, Journal of Neuroimmunology.

[4]  E. Lyukmanova,et al.  Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated , 2013, Brain Structure and Function.

[5]  H. Morishita,et al.  Regulating Critical Period Plasticity: Insight from the Visual System to Fear Circuitry for Therapeutic Interventions , 2013, Front. Psychiatry.

[6]  C. Ulens,et al.  Structural insights into Cys-loop receptor function and ligand recognition. , 2013, Biochemical pharmacology.

[7]  E. Parisini,et al.  Ly6 family proteins in neutrophil biology , 2013, Journal of leukocyte biology.

[8]  S. Abdelhak,et al.  Particular Mal de Meleda Phenotypes in Tunisia and Mutations Founder Effect in the Mediterranean Region , 2013, BioMed research international.

[9]  Lin Chen,et al.  Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors. , 2013, The Biochemical journal.

[10]  Lin Chen,et al.  Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera. , 2013, The Biochemical journal.

[11]  S. Ishii,et al.  Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells. , 2013, Biochemical and biophysical research communications.

[12]  Michal Linial,et al.  Short Toxin-like Proteins Attack the Defense Line of Innate Immunity , 2013, Toxins.

[13]  R. Smith,et al.  Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59 , 2013, Cell reports.

[14]  P. Bregestovski,et al.  Water-soluble LYNX1 Residues Important for Interaction with Muscle-type and/or Neuronal Nicotinic Receptors* , 2013, The Journal of Biological Chemistry.

[15]  Y. Utkin Three-finger toxins, a deadly weapon of elapid venom--milestones of discovery. , 2013, Toxicon : official journal of the International Society on Toxinology.

[16]  A. Galat Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands , 2012, Cellular and Molecular Life Sciences.

[17]  Nam-Chul Kim,et al.  The Ly6 neurotoxin‐like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila , 2012, Developmental neurobiology.

[18]  J. Miwa,et al.  Enhancement in Motor Learning through Genetic Manipulation of the Lynx1 Gene , 2012, PloS one.

[19]  Dominique Douguet,et al.  Black mamba venom peptides target acid-sensing ion channels to abolish pain , 2012, Nature.

[20]  E. Spindel,et al.  The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[21]  J. Changeux The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily* , 2012, The Journal of Biological Chemistry.

[22]  R. Efremov,et al.  Structure and dynamics of cardiotoxins. , 2012, Current protein & peptide science.

[23]  D. Svergun,et al.  A Flexible Multidomain Structure Drives the Function of the Urokinase-type Plasminogen Activator Receptor (uPAR)* , 2012, The Journal of Biological Chemistry.

[24]  Masahiko Watanabe,et al.  Localization of Acetylcholine-Related Molecules in the Retina: Implication of the Communication from Photoreceptor to Retinal Pigment Epithelium , 2012, PloS one.

[25]  H. Lester,et al.  Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. , 2012, Physiology.

[26]  Xiang Xu,et al.  Crystal structure of the urokinase receptor in a ligand-free form. , 2012, Journal of molecular biology.

[27]  V. Tsetlin,et al.  Mitochondria Express α7 Nicotinic Acetylcholine Receptors to Regulate Ca2+ Accumulation and Cytochrome c Release: Study on Isolated Mitochondria , 2012, PloS one.

[28]  M. Nitabach,et al.  Tethering toxins and peptide ligands for modulation of neuronal function , 2012, Current Opinion in Neurobiology.

[29]  D. Bertrand,et al.  Dimeric α-Cobratoxin X-ray Structure , 2012, The Journal of Biological Chemistry.

[30]  A. Müller,et al.  Selective and programmed cleavage of GPI-anchored proteins from the surface membrane by phospholipase C. , 2012, Biochimica et biophysica acta.

[31]  Lin Chen,et al.  Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist , 2011, Nature Neuroscience.

[32]  Y. Utkin,et al.  Inhibition of the Nicotinic Acetylcholine Receptors by Cobra Venom α-Neurotoxins: Is There a Perspective in Lung Cancer Treatment? , 2011, PloS one.

[33]  H. Lester,et al.  Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses , 2011, Neuron.

[34]  A. Galat Common structural traits for cystine knot domain of the TGFβ superfamily of proteins and three-fingered ectodomain of their cellular receptors , 2011, Cellular and Molecular Life Sciences.

[35]  D. Bertrand,et al.  NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1* , 2011, The Journal of Biological Chemistry.

[36]  I. Ibañez-Tallon,et al.  "The King is dead": Checkmating ion channels with tethered toxins. , 2010, Toxicon : official journal of the International Society on Toxinology.

[37]  Takao K. Hensch,et al.  Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex , 2010, Science.

[38]  I. Ibañez-Tallon,et al.  Silencing neurotransmission with membrane-tethered toxins , 2010, Nature Methods.

[39]  D. Bertrand,et al.  Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)*♦ , 2010, The Journal of Biological Chemistry.

[40]  A. Tekinay,et al.  Prostate Stem Cell Antigen Is an Endogenous lynx1-Like Prototoxin That Antagonizes α7-Containing Nicotinic Receptors and Prevents Programmed Cell Death of Parasympathetic Neurons , 2009, The Journal of Neuroscience.

[41]  T. Sixma,et al.  Insight in nAChR subtype selectivity from AChBP crystal structures. , 2009, Biochemical pharmacology.

[42]  N. Absalom,et al.  Alpha9 nicotinic acetylcholine receptors and the treatment of pain. , 2009, Biochemical pharmacology.

[43]  Y. Utkin,et al.  Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors. , 2009, Biochemical pharmacology.

[44]  Ya. L. Polyak,et al.  Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors , 2009, The FEBS journal.

[45]  D. Swandulla,et al.  Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6 , 2009, European Neuropsychopharmacology.

[46]  Zewen Liu,et al.  Identification of two Lynx proteins in Nilaparvata lugens and the modulation on insect nicotinic acetylcholine receptors , 2009, Journal of neurochemistry.

[47]  Y. Utkin,et al.  Naturally occurring and synthetic peptides acting on nicotinic acetylcholine receptors. , 2009, Current pharmaceutical design.

[48]  P. Greengard,et al.  A role for LYNX2 in anxiety-related behavior , 2009, Proceedings of the National Academy of Sciences.

[49]  S. Nirthanan,et al.  Irditoxin, a novel covalently linked heterodimeric three‐finger toxin with high taxon‐specific neurotoxicity , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  H. Sekhon,et al.  Activated cholinergic signaling provides a target in squamous cell lung carcinoma. , 2008, Cancer research.

[51]  I. Pastan,et al.  PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity* , 2008, Journal of Biological Chemistry.

[52]  A. Ménez,et al.  Conserved structural determinants in three‐fingered protein domains , 2008, The FEBS journal.

[53]  Byung-Hwan Lee,et al.  Pr-lynx1, a modulator of nicotinic acetylcholine receptors in the insect , 2008, Molecular and Cellular Neuroscience.

[54]  D. Bertrand,et al.  Naturally Occurring Disulfide-bound Dimers of Three-fingered Toxins , 2008, Journal of Biological Chemistry.

[55]  T. Hughes,et al.  High-resolution structures of bacterially expressed soluble human CD59. , 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

[56]  J. Stroud,et al.  Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution , 2007, Nature Neuroscience.

[57]  J. Changeux,et al.  Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures , 2007, Journal of neurochemistry.

[58]  K. Kawashima,et al.  Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands. , 2007, Life sciences.

[59]  D. I. Rzhevsky,et al.  Behavioural effects in mice and intoxication symptomatology of weak neurotoxin from cobra Naja kaouthia. , 2007, Basic & clinical pharmacology & toxicology.

[60]  D. Shaw,et al.  Structural basis of interaction between urokinase-type plasminogen activator and its receptor. , 2006, Journal of molecular biology.

[61]  R. Abagyan,et al.  Defining the CD59-C9 Binding Interaction* , 2006, Journal of Biological Chemistry.

[62]  H. Lester,et al.  The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo , 2006, Neuron.

[63]  S. Grando,et al.  SLURP‐2: A novel cholinergic signaling peptide in human mucocutaneous epithelium , 2006, Journal of cellular physiology.

[64]  Corey M. McCann,et al.  The cholinergic antagonist α-bungarotoxin also binds and blocks a subset of GABA receptors , 2006 .

[65]  D. Shaw,et al.  Structure of Human Urokinase Plasminogen Activator in Complex with Its Receptor , 2006, Science.

[66]  R. Abagyan,et al.  Insights into the Human CD59 Complement Binding Interface Toward Engineering New Therapeutics* , 2005, Journal of Biological Chemistry.

[67]  T. Sixma,et al.  Crystal Structure of Acetylcholine-binding Protein from Bulinus truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors* , 2005, Journal of Biological Chemistry.

[68]  D. Bertrand,et al.  Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant , 2005, Nature Structural &Molecular Biology.

[69]  A. Ménez,et al.  Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide , 2005, The EMBO journal.

[70]  P. Taylor,et al.  Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors , 2005, The EMBO journal.

[71]  N. Unwin,et al.  Refined structure of the nicotinic acetylcholine receptor at 4A resolution. , 2005, Journal of molecular biology.

[72]  D. I. Rzhevsky,et al.  Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors. , 2005, Toxicon : official journal of the International Society on Toxinology.

[73]  W. Chuang,et al.  Solution structure of γ‐bungarotoxin: The functional significance of amino acid residues flanking the RGD motif in integrin binding , 2004, Proteins.

[74]  Paul Brehm,et al.  Tethering Naturally Occurring Peptide Toxins for Cell-Autonomous Modulation of Ion Channels and Receptors In Vivo , 2004, Neuron.

[75]  Y. Utkin,et al.  The first representative of glycosylated three-fingered toxins. Cytotoxin from the Naja kaouthia cobra venom. , 2004, European journal of biochemistry.

[76]  I. Hampson,et al.  GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy , 2004, Clinical & Experimental Metastasis.

[77]  Laure Plantard,et al.  Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. , 2003, Human molecular genetics.

[78]  J. Changeux,et al.  Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines. , 2003, Molecular pharmacology.

[79]  Vladimir Brusic,et al.  Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins , 2003, Journal of Molecular Evolution.

[80]  M. Ploug Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor. , 2003, Current pharmaceutical design.

[81]  D. Bertrand,et al.  Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus) , 2003, British journal of pharmacology.

[82]  P. Gopalakrishnakone,et al.  Non-conventional toxins from Elapid venoms. , 2003, Toxicon : official journal of the International Society on Toxinology.

[83]  D. Bertrand,et al.  Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (αβγδ) but a Poorly Reversible Antagonist of Neuronal α7 Nicotinic Acetylcholine Receptors* , 2002, The Journal of Biological Chemistry.

[84]  Andrea Piserchio,et al.  NMR Structural Analysis of α-Bungarotoxin and Its Complex with the Principal α-Neurotoxin-binding Sequence on the α7 Subunit of a Neuronal Nicotinic Acetylcholine Receptor* , 2002, The Journal of Biological Chemistry.

[85]  N. Heintz,et al.  Novel Modulation of Neuronal Nicotinic Acetylcholine Receptors by Association with the Endogenous Prototoxin lynx1 , 2002, Neuron.

[86]  H. Hennies,et al.  Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates , 2002, Human Genetics.

[87]  Joel L. Sussman,et al.  The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide , 2001, Neuron.

[88]  T. Sixma,et al.  A glia-derived acetylcholine-binding protein that modulates synaptic transmission , 2001, Nature.

[89]  T. Sixma,et al.  Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors , 2001, Nature.

[90]  D Bertrand,et al.  “Weak Toxin” from Naja kaouthia Is a Nontoxic Antagonist of α7 and Muscle-type Nicotinic Acetylcholine Receptors* , 2001, The Journal of Biological Chemistry.

[91]  S. Wattler,et al.  Structural and phylogenetic characterization of human SLURP‐1, the first secreted mammalian member of the Ly‐6/uPAR protein superfamily , 2008, Protein science : a publication of the Protein Society.

[92]  V. Tsetlin Snake venom alpha-neurotoxins and other 'three-finger' proteins. , 1999, European journal of biochemistry.

[93]  A. Sali,et al.  lynx1, an Endogenous Toxin-like Modulator of Nicotinic Acetylcholine Receptors in the Mammalian CNS , 1999, Neuron.

[94]  G. A. Grant,et al.  Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist. , 1998, Biochemistry.

[95]  M. Loda,et al.  Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[96]  W. R. Weaver,et al.  Binding of native κ-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors , 1996 .

[97]  G. Kleywegt,et al.  Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. , 1995, Structure.

[98]  J. Sacchettini,et al.  Crystal structure of kappa-bungarotoxin at 2.3-A resolution. , 1994, Biochemistry.

[99]  I. Campbell,et al.  Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. , 1994, Biochemistry.

[100]  M. Lazdunski,et al.  Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[101]  G. Petsko,et al.  The crystal structure of a post‐synaptic neurotoxin from sea snake at 2.2 Å resolution , 1976, FEBS letters.

[102]  J. Richardson,et al.  Three dimensional structure of erabutoxin b neurotoxic protein: inhibitor of acetylcholine receptor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[103]  C. Y. Lee,et al.  ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION. , 1963, Archives internationales de pharmacodynamie et de therapie.