A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.

[1]  E. Heiss,et al.  AMPK and NRF2: Interactive players in the same team for cellular homeostasis? , 2022, Free radical biology & medicine.

[2]  Yun Yu,et al.  The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner. , 2021, Molecular immunology.

[3]  Yun Yu,et al.  Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway. , 2020, International immunopharmacology.

[4]  M. Karin,et al.  An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis , 2020, Science.

[5]  F. Tacke,et al.  Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis , 2019, Hepatology.

[6]  Masayuki Yamamoto,et al.  The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. , 2018, Physiological reviews.

[7]  Michael Charlton,et al.  The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases , 2018, Hepatology.

[8]  S. Friend,et al.  Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes , 2017, Science Translational Medicine.

[9]  F. Tacke Targeting hepatic macrophages to treat liver diseases. , 2017, Journal of hepatology.

[10]  P. Muckett,et al.  Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet , 2017, Cell reports.

[11]  Shuichi Kaneko,et al.  Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice , 2017, Diabetes.

[12]  A. D. de Vos,et al.  Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. , 2016, Cell reports.

[13]  G. Steinberg,et al.  Treatment of nonalcoholic fatty liver disease: role of AMPK. , 2016, American journal of physiology. Endocrinology and metabolism.

[14]  V. B. Konkimalla,et al.  Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes. , 2016, International immunopharmacology.

[15]  K. Nakayama,et al.  Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription , 2016, Nature Communications.

[16]  Alexis M. Kalergis,et al.  Innate Immunity and Inflammation in NAFLD/NASH , 2016, Digestive Diseases and Sciences.

[17]  M. Kikuchi,et al.  Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. , 2015, World journal of gastroenterology.

[18]  J. Hayes,et al.  The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.

[19]  Ajay C Donepudi,et al.  Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue , 2013, PloS one.

[20]  J. Coombes,et al.  Sulforaphane: translational research from laboratory bench to clinic. , 2013, Nutrition reviews.

[21]  D. Hardie,et al.  AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation , 2013, Cell metabolism.

[22]  S. Kaneko,et al.  CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status , 2012, Diabetes.

[23]  N. Van Rooijen,et al.  Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[24]  K. Cusi,et al.  Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. , 2012, Gastroenterology.

[25]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[26]  T. Luedde,et al.  Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury , 2011, Gut.

[27]  I. G. Fantus,et al.  Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice , 2011, Diabetologia.

[28]  M. Czaja JNK regulation of hepatic manifestations of the metabolic syndrome , 2010, Trends in Endocrinology & Metabolism.

[29]  H. Ginsberg,et al.  C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis , 2010, Diabetes.

[30]  M. Czaja,et al.  Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance , 2009, Hepatology.

[31]  J. Olefsky,et al.  Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. , 2008, Cell Metabolism.

[32]  Z. Varghese,et al.  Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice , 2008, Hepatology.

[33]  Vidya Subramanian,et al.  Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. , 2008, Cell metabolism.

[34]  Ken Itoh,et al.  Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages* , 2000, The Journal of Biological Chemistry.

[35]  A. Muñoz,et al.  Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. , 2012, Carcinogenesis.