A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.
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[1] E. Heiss,et al. AMPK and NRF2: Interactive players in the same team for cellular homeostasis? , 2022, Free radical biology & medicine.
[2] Yun Yu,et al. The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner. , 2021, Molecular immunology.
[3] Yun Yu,et al. Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway. , 2020, International immunopharmacology.
[4] M. Karin,et al. An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis , 2020, Science.
[5] F. Tacke,et al. Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis , 2019, Hepatology.
[6] Masayuki Yamamoto,et al. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. , 2018, Physiological reviews.
[7] Michael Charlton,et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases , 2018, Hepatology.
[8] S. Friend,et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes , 2017, Science Translational Medicine.
[9] F. Tacke. Targeting hepatic macrophages to treat liver diseases. , 2017, Journal of hepatology.
[10] P. Muckett,et al. Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet , 2017, Cell reports.
[11] Shuichi Kaneko,et al. Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice , 2017, Diabetes.
[12] A. D. de Vos,et al. Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. , 2016, Cell reports.
[13] G. Steinberg,et al. Treatment of nonalcoholic fatty liver disease: role of AMPK. , 2016, American journal of physiology. Endocrinology and metabolism.
[14] V. B. Konkimalla,et al. Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes. , 2016, International immunopharmacology.
[15] K. Nakayama,et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription , 2016, Nature Communications.
[16] Alexis M. Kalergis,et al. Innate Immunity and Inflammation in NAFLD/NASH , 2016, Digestive Diseases and Sciences.
[17] M. Kikuchi,et al. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. , 2015, World journal of gastroenterology.
[18] J. Hayes,et al. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.
[19] Ajay C Donepudi,et al. Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue , 2013, PloS one.
[20] J. Coombes,et al. Sulforaphane: translational research from laboratory bench to clinic. , 2013, Nutrition reviews.
[21] D. Hardie,et al. AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation , 2013, Cell metabolism.
[22] S. Kaneko,et al. CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status , 2012, Diabetes.
[23] N. Van Rooijen,et al. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. , 2012, American journal of physiology. Gastrointestinal and liver physiology.
[24] K. Cusi,et al. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. , 2012, Gastroenterology.
[25] D. Hardie,et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.
[26] T. Luedde,et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury , 2011, Gut.
[27] I. G. Fantus,et al. Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice , 2011, Diabetologia.
[28] M. Czaja. JNK regulation of hepatic manifestations of the metabolic syndrome , 2010, Trends in Endocrinology & Metabolism.
[29] H. Ginsberg,et al. C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis , 2010, Diabetes.
[30] M. Czaja,et al. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance , 2009, Hepatology.
[31] J. Olefsky,et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. , 2008, Cell Metabolism.
[32] Z. Varghese,et al. Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice , 2008, Hepatology.
[33] Vidya Subramanian,et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. , 2008, Cell metabolism.
[34] Ken Itoh,et al. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages* , 2000, The Journal of Biological Chemistry.
[35] A. Muñoz,et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. , 2012, Carcinogenesis.