Magnetic Two-Way Valves for Paper-Based Capillary-Driven Microfluidic Devices

This article presents a magnetically actuated two-way, three-position (+, 0, −), paper-based microfluidic valve that includes a neutral position (0)—the first of its kind. The system is highly robust, customizable, and fully automated. The advent of a neutral position and the ability to precisely control switching frequencies establish a new platform for highly controlled fluid flows in paper-based wicking microfluidic devices. The potential utility of these valves is demonstrated in automated, programmed, patterning of dyed liquids in a wicking device akin to a colorimetric assay but with a programmed fluid/reagent delivery. These valves are fabricated using facile methods and thus remain cost-effective for adoption into affordable point-of-care/bioanalytical devices.

[1]  Fei Li,et al.  Advances in paper-based point-of-care diagnostics. , 2014, Biosensors & bioelectronics.

[2]  Kenneth Hawkins,et al.  Microfluidic diagnostics for low-resource settings , 2010, MOEMS-MEMS.

[3]  J. Justin Gooding,et al.  Recent Advances in Paper-Based Sensors , 2012, Sensors.

[4]  Katherine E. Boehle,et al.  Electrochemistry on Paper‐based Analytical Devices: A Review , 2016 .

[5]  E. W. Washburn.  The Dynamics of Capillary Flow , 1921 .

[6]  Reza Masoodi,et al.  Darcy's law‐based model for wicking in paper‐like swelling porous media , 2010 .

[7]  David R. Liu,et al.  Analytical Devices Based on Direct Synthesis of DNA on Paper. , 2016, Analytical chemistry.

[8]  Lauro T Kubota,et al.  Sensing approaches on paper-based devices: a review , 2013, Analytical and Bioanalytical Chemistry.

[9]  A. Hoekstra,et al.  Permeability of Three-Dimensional Random Fiber Webs , 1998 .

[10]  Zhihong Nie,et al.  Programmable diagnostic devices made from paper and tape. , 2010, Lab on a chip.

[11]  G. Whitesides,et al.  Electrically Activated Paper Actuators , 2016 .

[12]  Peter Kauffman,et al.  Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks. , 2010, Lab on a chip.

[13]  Richard Lucas,et al.  Ueber das Zeitgesetz des kapillaren Aufstiegs von Flüssigkeiten , 1918 .

[14]  Xinyu Liu,et al.  Magnetic timing valves for fluid control in paper-based microfluidics. , 2013, Lab on a chip.

[15]  Yong He,et al.  Fabrication of paper-based microfluidic analysis devices: a review , 2015 .