Mycobacterium avium complex infection in an immunocompetent young adult related to hot tub exposure.

An unusual case of Mycobacterium avium complex infection occurred in a young adult with no preexisting disease and no evidence of immunodeficiency. There was diffuse interstitial involvement of the lungs which suggested an active alveolitis. Diagnosis required open-lung biopsy. Restriction fragment length polymorphism analysis and multilocus enzyme electrophoresis indicated that the source of the infection was a hot tub. The infection proved to be exceptionally responsive to treatment, and there was complete resolution with a four-drug regimen.

[1]  M. Yakrus,et al.  Geographic distribution, frequency, and specimen source of Mycobacterium avium complex serotypes isolated from patients with acquired immunodeficiency syndrome , 1990, Journal of clinical microbiology.

[2]  J. Hedley-Whyte,et al.  Concentration of Mycobacterium avium by hospital hot water systems. , 1988, JAMA.

[3]  M. Yakrus,et al.  Characterization of isolates of Mycobacterium avium serotypes 4 and 8 from patients with AIDS by multilocus enzyme electrophoresis , 1992, Journal of clinical microbiology.

[4]  B. Parker,et al.  Epidemiology of infection by nontuberculous mycobacteria. IV. Preferential aerosolization of Mycobacterium intracellulare from natural waters. , 1983, The American review of respiratory disease.

[5]  M. Iseman Mycobacterium avium Complex and the Normal Hosts , 1989 .

[6]  R. Patterson,et al.  Sauna-takers disease. Hypersensitivity pneumonitis due to contaminated water in a home sauna. , 1976, JAMA.

[7]  D. Armstrong,et al.  Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. , 1986, Annals of internal medicine.

[8]  R. Arbeit,et al.  Persistent colonisation of potable water as a source of Mycobacterium avium infection in AIDS , 1994, The Lancet.

[9]  J. T. Crawford,et al.  Association of plasmids and virulence of Mycobacterium avium complex. , 1988, The American review of respiratory disease.

[10]  A. Telenti,et al.  A novel insertion element from Mycobacterium avium, IS1245, is a specific target for analysis of strain relatedness , 1995, Journal of clinical microbiology.

[11]  J. Wallace,et al.  Mycobacterium avium complex infection in patients with the acquired immunodeficiency syndrome. A clinicopathologic study. , 1988, Chest.

[12]  Horsburgh Cr Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. , 1991, The New England journal of medicine.

[13]  D. Peterson,et al.  Infection with Mycobacterium avium complex in patients without predisposing conditions. , 1989, The New England journal of medicine.

[14]  D. Rosenzweig,et al.  Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases. , 1979, Chest.

[15]  L. Heifets,et al.  Qualitative and quantitative drug-susceptibility tests in mycobacteriology. , 1988, The American review of respiratory disease.

[16]  S. Swensen,et al.  Mycobacterium avium-intracellulare complex: evaluation with CT. , 1993, Radiology.

[17]  B. Parker,et al.  Epidemiology of infection by nontuberculous Mycobacteria. III. Isolation of potentially pathogenic mycobacteria from aerosols. , 1980, The American review of respiratory disease.

[18]  A. Teirstein,et al.  Pulmonary infection with Mycobacterium avium-intracellulare: diagnosis, clinical patterns, treatment. , 1990, The Mount Sinai journal of medicine, New York.