Anti‐neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia—a case report and review of the literature

Neuronal autoantibodies can support the diagnosis of primary autoimmune cerebellar ataxia (PACA). Knowledge of PACA is still sparce. This article aims to highlight the relevance of anti‐neurochondrin antibodies and possible therapeutical consequences in people with PACA.

[1]  R. Wiest,et al.  Reliable brain morphometry from contrast‐enhanced T1w‐MRI in patients with multiple sclerosis , 2022, Human brain mapping.

[2]  Parker E. Bohm,et al.  Neurochondrin immunoglobulin G – Associated myelopathy – Ataxia syndrome , 2021, Journal of the Neurological Sciences.

[3]  Amanda L. Piquet,et al.  Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia , 2021, Frontiers in Neurology.

[4]  K. Bhatia,et al.  Autoimmune movement disorders with neuronal antibodies – an update , 2021, Current opinion in neurology.

[5]  F. Depierreux,et al.  Recurrent Ataxia and Dystonia with Anti-Neurochondrin Autoantibodies , 2021, Neuropediatrics.

[6]  R. Wiest,et al.  Direct cortical thickness estimation using deep learning‐based anatomy segmentation and cortex parcellation , 2020, Human brain mapping.

[7]  P. Sarrigiannis,et al.  Treatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate , 2020, The Cerebellum.

[8]  H. Mitoma,et al.  Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias , 2020, The Cerebellum.

[9]  H. Mitoma,et al.  Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias , 2020, The Cerebellum.

[10]  T. Fife,et al.  Autoimmune Vestibulocerebellar Syndromes , 2020, Seminars in Neurology.

[11]  Mark D Anderson,et al.  Neurochondrin neurological autoimmunity , 2019, Neurology: Neuroimmunology & Neuroinflammation.

[12]  Z. Weihua,et al.  Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia , 2019, The Cerebellum.

[13]  Schumacher Myriam,et al.  Encephalopathy Associated With Neurochondrin Autoantibodies. , 2019, Journal of child neurology.

[14]  H. Mitoma,et al.  Time Is Cerebellum , 2018, The Cerebellum.

[15]  B. Neubauer,et al.  Chorea Minor Associated with Anti-Neurochondrin Autoantibodies , 2017, Neuropediatrics.

[16]  D. Sanders,et al.  Causes of progressive cerebellar ataxia: prospective evaluation of 1500 patients , 2016, Journal of Neurology, Neurosurgery & Psychiatry.

[17]  L. Schöls,et al.  Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration , 2016, Neurology: Neuroimmunology & Neuroinflammation.

[18]  H. Mitoma,et al.  Guidelines for treatment of immune-mediated cerebellar ataxias , 2015, Cerebellum & Ataxias.

[19]  S. Jarius,et al.  ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook , 2015, Journal of Neuroinflammation.

[20]  S. Jarius,et al.  ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC , 2015, Journal of Neuroinflammation.

[21]  S. Jarius,et al.  ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII , 2015, Journal of Neuroinflammation.

[22]  S. Jarius,et al.  ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook , 2015, Journal of Neuroinflammation.

[23]  H. Mitoma,et al.  Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias , 2015, The Cerebellum.

[24]  康太 山内,et al.  Scale for the Assessment and Rating of Ataxia（SARA）を用いた脳卒中に伴う運動失調重症度評価の有用性について , 2013 .

[25]  H. Wiendl,et al.  Neuron-directed autoimmunity in the central nervous system: entities, mechanisms, diagnostic clues, and therapeutic options. , 2012, Current opinion in neurology.

[26]  V. Tesar,et al.  Pulse Versus Daily Oral Cyclophosphamide for Induction of Remission in Antineutrophil Cytoplasmic AntibodyAssociated Vasculitis , 2009, Annals of Internal Medicine.

[27]  G. Davies-Jones,et al.  Cerebellar ataxia as a possible organ‐specific autoimmune disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[28]  Dean A Seehusen,et al.  Cerebrospinal fluid analysis. , 2003, American family physician.