Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines

The objective of this study was to compare the efficacy of a commercial 21 porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype 22 PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both 23 vaccines were administered intramuscularly in 2 doses at 21 and 42 days of age, and the pigs 24 were challenged intranasally with HP-PRRSV at 63 days of age. Pigs vaccinated with the 25 prototype PRRS II subunit vaccine had significantly higher anti-PRRSV antibody titers, a 26 greater number of interferon-γ-secreting cells, and a greater reduction in lung lesion scores 27 compared to pigs vaccinated with the commercial PRRS subunit vaccine. Therefore, the 28 commercial PRRS subunit and prototype PRRS II subunit vaccines are efficacious against 29 HP-PRRSV. 30 31

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