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[1]  T. Horvath,et al.  Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. , 2012, Trends in molecular medicine.

[2]  M. Benito,et al.  Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction. , 2012, Endocrinology.

[3]  O. Boss,et al.  Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression , 1997, FEBS letters.

[4]  O. Pedersen,et al.  Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes , 2001, Diabetologia.

[5]  L. Tartaglia,et al.  Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis , 1997, Diabetes.

[6]  W. Arindrarto,et al.  Uncoupling protein 2 gene polymorphisms are associated with obesity , 2012, Cardiovascular Diabetology.

[7]  G. Sesti,et al.  The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes. , 2004, Diabetes.

[8]  M. Klingenberg,et al.  Structure and function of the uncoupling protein from brown adipose tissue. , 1999, Biochimica et Biophysica Acta.

[9]  J. Blanc,et al.  Protective Role of Uncoupling Protein 2 in Atherosclerosis , 2003, Circulation.

[10]  J. Park,et al.  Overexpression of Uncoupling Protein 2 in THP1 Monocytes Inhibits β2 Integrin-Mediated Firm Adhesion and Transendothelial Migration , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[11]  M. Lafontan,et al.  Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-α , 2000 .

[12]  A. Medvedev,et al.  Persistent Nuclear Factor-κB Activation in Ucp2-/- Mice Leads to Enhanced Nitric Oxide and Inflammatory Cytokine Production* , 2005, Journal of Biological Chemistry.

[13]  A. Lusis,et al.  Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in Mice , 2002, Circulation research.

[14]  R. Goyal,et al.  Evaluation of TNF-α and IL-6 Levels in Obese and Non-obese Diabetics: Pre- and Postinsulin Effects , 2012, North American journal of medical sciences.

[15]  V. Mootha,et al.  Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice* , 2000, The Journal of Biological Chemistry.

[16]  B. Miroux,et al.  Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production , 2000, Nature Genetics.

[17]  E. Tai,et al.  Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in Asians , 2006, Obesity.

[18]  Chunhui Jiang,et al.  Different effects of low- and high-dose insulin on ROS production and VEGF expression in bovine retinal microvascular endothelial cells in the presence of high glucose , 2011, Graefe's Archive for Clinical and Experimental Ophthalmology.

[19]  Y. Kim,et al.  The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells , 2005, Diabetologia.

[20]  Christophe Fleury,et al.  Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia , 1997, Nature Genetics.

[21]  W. Garvey,et al.  Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: effects of obesity and diabetes. , 1998, Diabetes.

[22]  Ilse Vanhorebeek,et al.  Intensive insulin therapy protects the endothelium of critically ill patients. , 2005, The Journal of clinical investigation.

[23]  Gangyi Yang,et al.  The adipose triglyceride lipase, adiponectin and visfatin are downregulated by tumor necrosis factor-alpha (TNF-alpha) in vivo. , 2009, Cytokine.

[24]  P. Kern,et al.  Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. , 2004, American journal of physiology. Endocrinology and metabolism.

[25]  L. Leon,et al.  Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3* , 2000, The Journal of Biological Chemistry.

[26]  M. Laville,et al.  Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. , 1997, The Journal of clinical investigation.

[27]  S. B. Pedersen,et al.  Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro. , 2001, Biochemical and biophysical research communications.

[28]  M. Benito,et al.  Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. , 2001, The Journal of clinical investigation.

[29]  A. Cassard-Doulcier,et al.  Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. , 2007, The Biochemical journal.

[30]  M. Benito,et al.  Implication of insulin receptor A isoform and IRA/IGF-IR hybrid receptors in the aortic vascular smooth muscle cell proliferation: role of TNF-α and IGF-II. , 2013, Endocrinology.

[31]  T. Kizaki,et al.  Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Daoyan Liu,et al.  TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction , 2013, Cardiovascular Diabetology.

[33]  V. Grill,et al.  Interleukin-1β swiftly down-regulates UCP-2 mRNA in β-cells by mechanisms not directly coupled to toxicity , 2003 .

[34]  D. Steinberg,et al.  The oxidative modification hypothesis of atherogenesis: an overview. , 2000, Free radical biology & medicine.

[35]  R. Ross The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[36]  M. Benito,et al.  Inhibition of PI 3‐kinase and RAS blocks IGF‐I and insulin‐induced uncoupling protein 1 gene expression in brown adipocytes , 1998, Journal of cellular physiology.

[37]  In-kyu Lee,et al.  The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells. , 2007, Diabetes research and clinical practice.

[38]  I. Cuthill,et al.  Reporting : The ARRIVE Guidelines for Reporting Animal Research , 2010 .

[39]  G. Vilahur,et al.  Atherothrombotic risk in obesity , 2013, Hämostaseologie.

[40]  In-kyu Lee,et al.  Upregulation of UCP2 by Adiponectin: The Involvement of Mitochondrial Superoxide and hnRNP K , 2012, PloS one.

[41]  M. Benito,et al.  Insulin-induced Up-regulated Uncoupling Protein-1 Expression Is Mediated by Insulin Receptor Substrate 1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Fetal Brown Adipocytes* , 2003, The Journal of Biological Chemistry.

[42]  Y. Obara,et al.  Regulation of uncoupling protein 2 expression by long-chain fatty acids and hormones in bovine mammary epithelial cells. , 2008, Biochemical and biophysical research communications.

[43]  S. Holland,et al.  p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. , 2001, The Journal of clinical investigation.

[44]  M. Laakso,et al.  Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. , 1998, The New England journal of medicine.

[45]  J. Maclouf,et al.  The relationship of hydroxyeicosatetraenoic acids and F2-isoprostanes to plaque instability in human carotid atherosclerosis. , 1999, The Journal of clinical investigation.