Semiparametric estimators for the regression coefficients in the linear transformation competing risks model with missing cause of failure

SUMMARY We consider the problem of estimating the regression coefficients in a competing risks model, where the relationship between the cause-specific hazard for the cause of interest and covariates is described using linear transformation models and when cause of failure is missing at random for a subset of individuals. Using the theory of Robins et al. (1994) for missing data problems and the approach of Chen et al. (2002) for estimating regression coefficients for linear transformation models, we derive augmented inverse probability weighted complete-case estimators for the regression coefficients that are doubly robust. Simulations demonstrate the relevance of the theory in finite samples.

[1]  Susan A. Murphy,et al.  Maximum Likelihood Estimation in the Proportional Odds Model , 1997 .

[2]  J. Robins,et al.  Estimation of Regression Coefficients When Some Regressors are not Always Observed , 1994 .

[3]  David R. Cox,et al.  Regression models and life tables (with discussion , 1972 .

[4]  Zhiliang Ying,et al.  On semiparametric transformation cure models , 2004 .

[5]  L Ryan,et al.  Missing cause of death information in the analysis of survival data. , 1996, Statistics in medicine.

[6]  James M. Robins,et al.  Adjusting for Nonignorable Drop-Out Using Semiparametric Nonresponse Models: Rejoinder , 1999 .

[7]  D. Rubin INFERENCE AND MISSING DATA , 1975 .

[8]  Anthony N. Pettitt,et al.  Proportional Odds Models for Survival Data and Estimates Using Ranks , 1984 .

[9]  Zhiliang Ying,et al.  Semiparametric analysis of transformation models with censored data , 2002 .

[10]  A A Tsiatis,et al.  Multiple Imputation Methods for Estimating Regression Coefficients in the Competing Risks Model with Missing Cause of Failure , 2001, Biometrics.

[11]  Zhiliang Ying,et al.  On the linear transformation model for censored data , 1998 .

[12]  Tianxi Cai,et al.  Semiparametric regression analysis for clustered failure time data , 2000 .

[13]  Z. Ying,et al.  Analysis of transformation models with censored data , 1995 .

[14]  S. Bennett,et al.  Analysis of survival data by the proportional odds model. , 1983, Statistics in medicine.

[15]  D. Rubin Multiple Imputation After 18+ Years , 1996 .

[16]  Anthony N. Pettitt,et al.  Inference for the Linear Model Using a Likelihood Based on Ranks , 1982 .

[17]  Els Goetghebeur,et al.  Analysis of competing risks survival data when some failure types are missing , 1995 .