Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c.

[1]  Joon-Hyuk Choi,et al.  Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. , 2002, Anticancer research.

[2]  S. Berners‐Price,et al.  Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes: the possible role of mitochondria , 2002 .

[3]  J. Gustafsson,et al.  Human Mitochondrial Thioredoxin , 2002, The Journal of Biological Chemistry.

[4]  Dean P. Jones,et al.  Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells* , 2002, The Journal of Biological Chemistry.

[5]  A. Bindoli,et al.  Induction of mitochondrial permeability transition by auranofin, a Gold(I)‐phosphine derivative , 2002, British journal of pharmacology.

[6]  V. Gogvadze,et al.  Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms. , 2002, Biochemical and biophysical research communications.

[7]  Y. Yamaguchi-Iwai,et al.  Thioredoxin‐2 (TRX‐2) is an essential gene regulating mitochondria‐dependent apoptosis , 2002, The EMBO journal.

[8]  C. Chiueh,et al.  The Roles of Thioredoxin in Protection against Oxidative Stress-induced Apoptosis in SH-SY5Y Cells* , 2002, The Journal of Biological Chemistry.

[9]  Sten Orrenius,et al.  Cytochrome c release from mitochondria proceeds by a two-step process , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[10]  B. Zhivotovsky,et al.  Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax* , 2001, The Journal of Biological Chemistry.

[11]  L. Cesaro,et al.  Distribution of protein disulphide isomerase in rat liver mitochondria. , 2001, The Biochemical journal.

[12]  J. Martinou,et al.  Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells* , 2001, The Journal of Biological Chemistry.

[13]  Xiaodong Wang,et al.  Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.

[14]  Robert L Moritz,et al.  Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.

[15]  C. Shaw.  Gold-Based Therapeutic Agents , 1999 .

[16]  A. Bindoli,et al.  Mitochondrial permeability transition and release of cytochrome c induced by retinoic acids. , 1999, Biochemical pharmacology.

[17]  Ruedi Aebersold,et al.  Molecular characterization of mitochondrial apoptosis-inducing factor , 1999, Nature.

[18]  P. Bernardi,et al.  Mitochondrial transport of cations: channels, exchangers, and permeability transition. , 1999, Physiological reviews.

[19]  Jean-Claude Martinou,et al.  Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions , 1998, The Journal of cell biology.

[20]  J C Reed,et al.  Mitochondria and apoptosis. , 1998, Science.

[21]  R. Schirmer,et al.  Human Placenta Thioredoxin Reductase , 1998, The Journal of Biological Chemistry.

[22]  A. Bindoli,et al.  Influence of the redox state of pyridine nucleotides on mitochondrial sulfhydryl groups and permeability transition. , 1997, Archives of biochemistry and biophysics.

[23]  J. Dickinson,et al.  Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: targets for therapy. , 1997, Biochemical pharmacology.

[24]  M P Rigobello,et al.  Personal computer control of electrochemical detectors utilized for mitochondrial studies. , 1996, Computer methods and programs in biomedicine.

[25]  Xiaodong Wang,et al.  Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.

[26]  B. Chernyak,et al.  The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites. , 1996, European journal of biochemistry.

[27]  M. Zoratti,et al.  The mitochondrial permeability transition. , 1995, Biochimica et biophysica acta.

[28]  P. Bernardi,et al.  On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide. , 1995, Toxicology.

[29]  I. Fridovich,et al.  Paraquat diaphorases in Escherichia coli. , 1993, Free radical biology & medicine.

[30]  C. Mirabelli,et al.  The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. III. Chlorotriethylphosphine gold(I)-induced alterations in isolated rat liver mitochondrial function. , 1989, Toxicology and applied pharmacology.

[31]  J. Hoek,et al.  Physiological roles of nicotinamide nucleotide transhydrogenase. , 1988, The Biochemical journal.

[32]  C. Mirabelli,et al.  The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. II. Triethylphosphine gold chloride-induced alterations in mitochondrial function. , 1987, Toxicology and applied pharmacology.

[33]  S. Crooke,et al.  The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. I. Characterization of triethylphosphine gold chloride-induced biochemical and morphological changes in isolated hepatocytes. , 1987, Toxicology and applied pharmacology.

[34]  S. Crooke,et al.  Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes. , 1986, Journal of medicinal chemistry.

[35]  A. Tappel,et al.  Interaction of gold(I) with the active site of selenium-glutathione peroxidase. , 1984, Journal of inorganic biochemistry.

[36]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[37]  C. Little,et al.  Properties and regulation of glutathione peroxidase. , 1970, The Journal of biological chemistry.

[38]  E. C. Slater,et al.  The enzymic hydrolysis of adenosine triphosphate by liver mitochondria. I. Activities at different pH values. , 1957, The Biochemical journal.

[39]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[40]  A. Gornall,et al.  Determination of serum proteins by means of the biuret reaction. , 1949, The Journal of biological chemistry.

[41]  A. Bindoli,et al.  Mitochondrial thioredoxin reductase and thiol status. , 2002, Methods in enzymology.

[42]  Elias S. J. Arnér,et al.  Preparation and assay of mammalian thioredoxin and thioredoxin reductase. , 1999, Methods in enzymology.

[43]  D. Green,et al.  Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization , 1998, The EMBO journal.

[44]  M. Anderson,et al.  Determination of glutathione and glutathione disulfide in biological samples. , 1985, Methods in enzymology.

[45]  R. Estabrook.  [7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios , 1967 .