Defect-related luminescent mesoporous silica nanoparticles employed for novel detectable nanocarrier.

Uniform and well-dispersed walnut kernel-like mesoporous silica nanoparticles (MSNs) with diameters about 100 nm have been synthesized by a templating sol-gel route. After an annealing process, the as-obtained sample (DLMSNs) inherits the well-defined morphology and good dispersion of MSNs, and exhibits bright white-blue luminescence, higher specific surface area and pore volume, and better biocompatibility. The drug loading and release profiles show that DLMSNs have high drug loading capacity, and exhibit an initial burst release followed by a slow sustained release process. Interestingly, the luminescence intensity of the DLMSNs-DOX system increases gradually with the increase of cumulative released DOX, which can be verified by the confocal laser scanning images. The drug carrier DLMSNs can potentially be applied as a luminescent probe for monitoring the drug release process. Moreover, the DLMSNs-DOX system exhibits potent anticancer effect against three kinds of cancer cells (HeLa, MCF-7, and A549 cells).

[1]  Fei He,et al.  A yolk-like multifunctional platform for multimodal imaging and synergistic therapy triggered by a single near-infrared light. , 2015, ACS nano.

[2]  Patrick V. Almeida,et al.  Augmented cellular trafficking and endosomal escape of porous silicon nanoparticles via zwitterionic bilayer polymer surface engineering. , 2014, Biomaterials.

[3]  O. Farokhzad,et al.  Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[4]  K. Neoh,et al.  Functionalized mesoporous silica nanoparticles with mucoadhesive and sustained drug release properties for potential bladder cancer therapy. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[5]  Pengcheng Zhu,et al.  Perylene-derived single-component organic nanoparticles with tunable emission: efficient anticancer drug carriers with real-time monitoring of drug release. , 2014, ACS nano.

[6]  Xing-jie Liang,et al.  Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Jun Lin,et al.  Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications. , 2014, Chemical reviews.

[8]  Cuimiao Zhang,et al.  Biodistribution and toxicity assessment of europium-doped Gd2O3 nanotubes in mice after intraperitoneal injection , 2014, Journal of Nanoparticle Research.

[9]  Dongmei Yang,et al.  Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes. , 2014, Biomaterials.

[10]  Julia Xiaojun Zhao,et al.  Recent development of silica nanoparticles as delivery vectors for cancer imaging and therapy. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[11]  Xin Du,et al.  Developing Functionalized Dendrimer‐Like Silica Nanoparticles with Hierarchical Pores as Advanced Delivery Nanocarriers , 2013, Advanced materials.

[12]  Jun Lin,et al.  Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release , 2013 .

[13]  R. Zhuo,et al.  Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery. , 2013, Journal of the American Chemical Society.

[14]  K. Lam,et al.  Facile large-scale synthesis of monodisperse mesoporous silica nanospheres with tunable pore structure. , 2013, Journal of the American Chemical Society.

[15]  Paul C. Wang,et al.  Multifunctional hybrid silica nanoparticles for controlled doxorubicin loading and release with thermal and pH dually response. , 2013, Journal of materials chemistry. B.

[16]  Yao He,et al.  Silicon-nanowire-based nanocarriers with ultrahigh drug-loading capacity for in vitro and in vivo cancer therapy. , 2013, Angewandte Chemie.

[17]  Dongmei Yang,et al.  Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release. , 2013, Nanoscale.

[18]  Jun Lin,et al.  Defect-related luminescent materials: synthesis, emission properties and applications. , 2012, Chemical Society reviews.

[19]  Chong Peng,et al.  Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle‐Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch , 2012 .

[20]  Jun Lin,et al.  Functionalized mesoporous silica materials for controlled drug delivery. , 2012, Chemical Society reviews.

[21]  Jun Lin,et al.  Up-conversion cell imaging and pH-induced thermally controlled drug release from NaYF4/Yb3+/Er3+@hydrogel core-shell hybrid microspheres. , 2012, ACS nano.

[22]  Zhen Cheng,et al.  In vitro and in vivo uncaging and bioluminescence imaging by using photocaged upconversion nanoparticles. , 2012, Angewandte Chemie.

[23]  S. Jeong,et al.  pH-Tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs. , 2011, Angewandte Chemie.

[24]  Yao He,et al.  One-pot microwave synthesis of water-dispersible, ultraphoto- and pH-stable, and highly fluorescent silicon quantum dots. , 2011, Journal of the American Chemical Society.

[25]  Rakesh K. Sharma,et al.  Multifunctional silica nanoparticles with potentials of imaging and gene delivery. , 2011, Nanomedicine : nanotechnology, biology, and medicine.

[26]  Zhuoxuan Lu,et al.  Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. , 2011, Small.

[27]  Y. Liu,et al.  Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. , 2011, Nano letters.

[28]  H. Autrup,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549 , 2011, Archives of Toxicology.

[29]  Jun Lin,et al.  Luminescent porous silica fibers as drug carriers. , 2010, Chemistry.

[30]  Jun Lin,et al.  Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers , 2010 .

[31]  Shanshan Huang,et al.  Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery. , 2010, Biomaterials.

[32]  Yun Sun,et al.  Dual-modality in vivo imaging using rare-earth nanocrystals with near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties. , 2010, Biomaterials.

[33]  Feng Chen,et al.  Hollow/rattle-type mesoporous nanostructures by a structural difference-based selective etching strategy. , 2010, ACS nano.

[34]  C. Yi,et al.  Effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts. , 2010, Methods in molecular biology.

[35]  K. Öllinger,et al.  Regulation of apoptosis-associated lysosomal membrane permeabilization , 2010, Apoptosis.

[36]  Jun Lin,et al.  A magnetic, luminescent and mesoporous core-shell structured composite material as drug carrier. , 2009, Biomaterials.

[37]  Jun Lin,et al.  Tunable luminescence in monodisperse zirconia spheres. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[38]  X. Bokhimi,et al.  Cortisol controlled release by mesoporous silica. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[39]  V. S. Lin,et al.  Mesoporous silica nanoparticle-based double drug delivery system for glucose-responsive controlled release of insulin and cyclic AMP. , 2009, Journal of the American Chemical Society.

[40]  Hong Ding,et al.  Imaging pancreatic cancer using bioconjugated InP quantum dots. , 2009, ACS nano.

[41]  Juan L. Vivero-Escoto,et al.  Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. , 2009, Journal of the American Chemical Society.

[42]  G. Kroemer,et al.  Lysosomal membrane permeabilization in cell death , 2008, Oncogene.

[43]  Nastassja A. Lewinski,et al.  Cytotoxicity of nanoparticles. , 2008, Small.

[44]  Hongjie Dai,et al.  Supramolecular Chemistry on Water- Soluble Carbon Nanotubes for Drug Loading and Delivery , 2007 .

[45]  Brian G. Trewyn,et al.  Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications , 2007 .

[46]  M. Port,et al.  Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review , 2006, Fundamental & clinical pharmacology.

[47]  Chen Chang,et al.  Multifunctional composite nanoparticles: Magnetic, luminescent, and mesoporous , 2006 .

[48]  T. Schmedake,et al.  A Novel Approach to Monodisperse, Luminescent Silica Spheres , 2006 .

[49]  W. Wang,et al.  Luminescent Carbon Nanotubes by Surface Functionalization , 2006, Advanced Materials.

[50]  Jianfeng Chen,et al.  Drug-loaded, magnetic, hollow silica nanocomposites for nanomedicine. , 2005, Nanomedicine : nanotechnology, biology, and medicine.

[51]  M. Sailor,et al.  White Phosphors from a Silicate-Carboxylate Sol-Gel Precursor That Lack Metal Activator Ions , 1997 .