Modular multi-organ-on-chips platform with physicochemical sensor integration

Organs-on-chips systems are microfluidic three-dimensional miniature human organoid models designed to reproduce the key biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. While a wide variety of human organ-on-a-chip models have been created, there are limited reports on the inclusion of sensors, which are critical in continually measuring the microenvironmental parameters and the dynamic responses of the organoids to pharmaceutical compounds over extended periods of time. In addition, automated capability is strongly desired for long-term monitoring. Here, we report the development of a fully integrated multi-organ-on-chips platform in conjunction with modular physical, biochemical, and optical sensing units, which together is operated in a continuous and automated manner [1]. We believe that, this novel platform technology has opened a new avenue for integrating biomimetic organoids with the potential to achieve large-scale automation in drug screening processes.