论文信息 - Response to Blood Pressure in Mutant Rats Lacking the 5-Hydroxytryptamine Transporter

Response to Blood Pressure in Mutant Rats Lacking the 5-Hydroxytryptamine Transporter

We are pleased to become aware of research by Homberg et al,1 who investigated whether 5-hydroxytryptamine (5-HT) transporter (SERT) plays a role in regulating blood pressure in female SERT knockout rats. We agree with their interpretation that the absence of SERT does not exacerbate or reduce the ability of ωN-nitro-l-arginine (l-NNA) to elevate blood pressure increase …

S. Watts | K. Lookingland | W. Ni

[1] J. Homberg,et al. Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter. , 2006, Hypertension.

[2] Dennis L. Murphy,et al. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter , 2005, Neuropharmacology.

[3] D. Murphy,et al. 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter , 2005, Psychopharmacology.

[4] D. Murphy,et al. Maintenance of Serotonin in the Intestinal Mucosa and Ganglia of Mice that Lack the High-Affinity Serotonin Transporter: Abnormal Intestinal Motility and the Expression of Cation Transporters , 2001, The Journal of Neuroscience.