Axially resolved complete mueller matrix confocal microscopy.

We introduce a technique that is capable of obtaining complete polarization-sensitive three-dimensional images that could reveal unknown anatomical conditions of living tissue that possess polarization-dependent signatures. Previously, the 16 Mueller coefficients were measured independently only by use of two-dimensional imaging techniques. We also present the experimental combination of a depth-resolved confocal imaging system with a complete Mueller matrix polarimeter. To calibrate the system, a double-pass method had to be implemented. We also indicate, experimentally, that the confocal sectioning of the system has a degrading effect on axially resolved Mueller matrix measurements.

[1]  R. Jones A New Calculus for the Treatment of Optical Systems. IV. , 1942 .

[2]  R. Clark Jones,et al.  A New Calculus for the Treatment of Optical Systems. VII. Properties of the N-Matrices , 1948 .

[3]  R. Azzam,et al.  Ellipsometry and polarized light , 1977 .

[4]  Rasheed M. A. Azzam,et al.  Propagation of partially polarized light through anisotropic media with or without depolarization: A differential 4 × 4 matrix calculus , 1978 .

[5]  R. M. A. Azzam,et al.  Division-of-amplitude Photopolarimeter (DOAP) for the Simultaneous Measurement of All Four Stokes Parameters of Light , 1982 .

[6]  E. Bernabeu,et al.  A Depolarization Criterion in Mueller Matrices , 1985 .

[7]  Eusebio Bernabeu,et al.  Depolarization and polarization indices of an optical system , 1986 .

[8]  J. Pawley,et al.  Handbook of Biological Confocal Microscopy , 1990, Springer US.

[9]  Y. Andrienko,et al.  Optical tomography of a birefringent medium , 1992 .

[10]  S. Krishnan,et al.  Calibration, properties, and applications of the division-of-amplitude photopolarimeter at 632.8 and 1523 nm , 1992 .

[11]  R. Azzam,et al.  Parallel-slab division-of-amplitude photopolarimeter. , 1996, Optics letters.

[12]  Sixteen-beam grating-based division-of-amplitude photopolarimeter. , 1995, Optics letters.

[13]  J. Hovenier,et al.  Testing scattering matrices: A compendium of recipes , 1996 .

[14]  Poul M. F. Nielsen,et al.  Polarization‐sensitive scanned fiber confocal microscope , 1996 .

[15]  R. Chipman,et al.  Interpretation of Mueller matrices based on polar decomposition , 1996 .

[16]  M. V. van Gemert,et al.  Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography , 1997, European Conference on Biomedical Optics.

[17]  F. Delplancke,et al.  Automated high-speed Mueller matrix scatterometer. , 1997, Applied optics.

[18]  D. Atchison,et al.  The eye and visual optical instruments: Frontmatter , 1997 .

[19]  Eric Compain,et al.  Complete high-frequency measurement of Mueller matrices based on a new coupled-phase modulator , 1997 .

[20]  T. Wilson,et al.  Rigorous theory for axial resolution in confocal microscopes , 1997 .

[21]  Eric Compain,et al.  High-frequency modulation of the four states of polarization of light with a single phase modulator , 1998 .

[22]  B. Drévillon,et al.  Broadband Division-of-Amplitude Polarimeter Based on Uncoated Prisms. , 1998, Applied optics.

[23]  M J Everett,et al.  Mapping of Birefringence and Thermal Damage in Tissue by use of Polarization-Sensitive Optical Coherence Tomography. , 1998, Applied optics.

[24]  P. D. Higdon,et al.  On the general properties of polarised light conventional and confocal microscopes , 1998 .

[25]  B. Drévillon,et al.  General and self-consistent method for the calibration of polarization modulators, polarimeters, and mueller-matrix ellipsometers. , 1999, Applied optics.

[26]  C. Mee An eigenvalue criterion for matrices transforming Stokes parameters , 1999 .

[27]  G. Yao,et al.  Two-dimensional depth-resolved Mueller matrix characterization of biological tissue by optical coherence tomography. , 1999, Optics letters.

[28]  Performance optimization and light-beam-deviation analysis of the parallel-slab division-of-amplitude photopolarimeter. , 1999, Applied optics.

[29]  H. G. Rylander,et al.  Polarization sensitive optical coherence tomography of the rabbit eye , 1999 .

[30]  Peter Török,et al.  Imaging of small birefringent objects by polarised light conventional and confocal microscopes , 2000 .

[31]  J. Scott Tyo Considerations in polarimeter design , 2000, SPIE Optics + Photonics.

[32]  L V Wang,et al.  Depth-resolved two-dimensional stokes vectors of backscattered light and mueller matrices of biological tissue measured with optical coherence tomography. , 2000, Applied optics.

[33]  Juan M. Bueno,et al.  Polarimetry using liquid-crystal variable retarders : theory and calibration , 2000 .

[34]  Mark C. Pierce,et al.  In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography , 2002 .

[35]  T. Milner,et al.  Review of polarization sensitive optical coherence tomography and Stokes vector determination. , 2002, Journal of biomedical optics.

[36]  Matthew H. Smith,et al.  Optimization of a dual-rotating-retarder Mueller matrix polarimeter. , 2002, Applied optics.

[37]  Lihong V. Wang,et al.  Propagation of polarized light in birefringent turbid media: a Monte Carlo study. , 2002, Journal of biomedical optics.

[38]  J. Tyo Design of optimal polarimeters: maximization of signal-to-noise ratio and minimization of systematic error. , 2002, Applied optics.

[39]  R. Azzam,et al.  Optimal beam splitters for the division-of-amplitude photopolarimeter. , 2003, Journal of the Optical Society of America. A, Optics, image science, and vision.

[40]  Antonello De Martino,et al.  Optimized Mueller polarimeter with liquid crystals. , 2003, Optics letters.

[41]  Michael Pircher,et al.  Transversal phase resolved polarization sensitive optical coherence tomography , 2004, Physics in medicine and biology.

[42]  E. García-Caurel,et al.  General methods for optimized design and calibration of Mueller polarimeters , 2004 .

[43]  S. Inoué,et al.  Foundations of Confocal Scanned Imaging in Light Microscopy , 2006 .