The frequent use of synthetic pesticides and their subsequent fate in the environment poses a major health implication to the population. Determination of these residues is necessary to ascertain human exposure as a result of contaminated dietary intake. In the present study chromatographic techniques, thin layer chromatography and high pressure liquid chromatography, have been employed for qualitative and quantitative determination of selected pesticides and insecticides in waste water of drains which is used to fulfill agricultural and irrigation needs of the area. Water samples collected from Chota Ravi Drain, Gulshan-e-Ravi Drain, Saggian Drain, Hudiara Drain, Mian Mir Drain and Kharak Drain were analyzed. The results showed that Hudiara Drain, Mian Mir Drain and Kharak Drain were severely contaminated with insecticide Deltomethrinin at concentration of 0.91 mg/l, 1.75 mg/l and 2.05 mg/l, respectively and pesticide Crypermethrin in concentration of 7.17 mg/l, 6.23 mg/l and 0.47 mg/l, while Chorophyrophos concentration was 441.02 mg/l, 383.3 mg/l and 29.04 mg/l, respectively. The presence of these persistent agrochemicals in drain is disturbing as throughout the year farmers’ use this water for irrigation and these agrochemicals has the potential to enter the food chain thus adversely effecting environment and human health.