METHOXYFLURANE: A CLINICAL STUDY OF FIFTY SELECTED CASES.

SUMMARY Fifty patients were anaesthetized using methoxyflurane, nitrous oxide and oxygen. Thiopentone enabled the induction time to be shortened. Respiratory depression particularly associated with reduction in tidal volume was observed. Hypotension was common and was often unrelated to depth of anaesthesia. There were episodes of bradycardia with hypotension. Muscle relaxation was good. Bleeding was diminished, no contraindication to the use of diathermy existed and adrenaline infiltrations were used without incident. Blood sugar levels were higher during anaesthesia and in the immediate postoperative period. Serum transaminase levels before and after anaesthesia indicate that methoxyflurane does not cause liver damage. The requirements of postoperative analgesics were considerably reduced. The incidence of postoperative nausea and vomiting was high. Protective reflexes were usually present at the end of operation but recovery of consciousness was greatly delayed.

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