Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene

[1]  V. Arlt,et al.  The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice , 2015, Archives of Toxicology.

[2]  V. Arlt,et al.  Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  P. White,et al.  TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts , 2015, Mutation research.

[4]  J. Kucab,et al.  Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism , 2014, Archives of Toxicology.

[5]  R. Godschalk,et al.  Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene. , 2014, Mutagenesis.

[6]  V. Arlt,et al.  Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. , 2014, Toxicology.

[7]  J. Tomblin,et al.  Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells. , 2014, Biochemical and biophysical research communications.

[8]  R. Godschalk,et al.  Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene , 2013, Front. Oncol..

[9]  S. Albelda,et al.  Tumor-associated neutrophils: friend or foe? , 2012, Carcinogenesis.

[10]  S. Amin,et al.  Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes , 2012, Journal of carcinogenesis.

[11]  P. Kirkham,et al.  LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling , 2012, Journal of Inflammation.

[12]  Verena Wilhelmi,et al.  Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles. , 2010, Free radical biology & medicine.

[13]  R. Godschalk,et al.  Genotoxic effects of neutrophils and hypochlorous acid. , 2010, Mutagenesis.

[14]  J. Pennings,et al.  Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils , 2010, Respiratory research.

[15]  A. Haugen,et al.  Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines. , 2010, Toxicology letters.

[16]  E. Wouters,et al.  Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. , 2010, Mutagenesis.

[17]  P. Dagnelie,et al.  Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils. , 2010, Drug metabolism and pharmacokinetics.

[18]  E. Frei,et al.  Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method , 2009, Interdisciplinary toxicology.

[19]  Alberto Mantovani,et al.  Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. , 2009, Carcinogenesis.

[20]  P. Metcalf,et al.  COPD prevalence is increased in lung cancer, independent of age, sex and smoking history , 2009, European Respiratory Journal.

[21]  Shuji Ohno,et al.  Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction , 2009, Drug Metabolism and Disposition.

[22]  L. Luttrell,et al.  Insulin-like growth factor-2/mannose-6 phosphate receptors. , 2009, Vitamins and hormones.

[23]  M. Makishima,et al.  Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. , 2008, Toxicology and applied pharmacology.

[24]  L. Kaminsky,et al.  Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. , 2008, Toxicology and applied pharmacology.

[25]  V. Arlt,et al.  Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo : experiments with Hepatic Cytochrome P450 Reductase Null mice , 2008 .

[26]  A. Y. Lu,et al.  CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies , 2007, Drug Metabolism and Disposition.

[27]  A. Y. Lu,et al.  CYP 1 A Induction and Human Risk Assessment : An Evolving Tale of in Vitro and in Vivo Studies , 2007 .

[28]  Roel P F Schins,et al.  Neutrophils and respiratory tract DNA damage and mutagenesis: a review. , 2006, Mutagenesis.

[29]  T. Shimada,et al.  Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. , 2006, Chemical research in toxicology.

[30]  K. Ley,et al.  Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[31]  W. Sly,et al.  Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[32]  T. Nakayama,et al.  Glucuronidase deconjugation in inflammation. , 2005, Methods in enzymology.

[33]  W. Sly,et al.  Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  P. Borm,et al.  Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[35]  N. Altorki,et al.  Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. , 2003, Carcinogenesis.

[36]  B. Floriańczyk,et al.  Beta-glucuronidase in physiology and disease. , 2003, Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.

[37]  Philip Lazarus,et al.  Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[38]  R. Kurten,et al.  Nuclear UDP-glucuronosyltransferases: identification of UGT2B7 and UGT1A6 in human liver nuclear membranes. , 2002, Archives of biochemistry and biophysics.

[39]  L. Kaminsky,et al.  Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[40]  S. Weitzman,et al.  Chronic inflammation and cancer. , 2002, Oncology.

[41]  D. Warshawsky,et al.  Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. , 2001, Biochemical and biophysical research communications.

[42]  K. Shimoi,et al.  Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[43]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[44]  A. González-Noriega,et al.  Mannose 6-phosphate-independent endocytosis of β-glucuronidase , 2001 .

[45]  F. Massó,et al.  Mannose 6-phosphate-independent endocytosis of β-glucuronidase by human fibroblasts , 2001 .

[46]  F. Massó,et al.  Mannose 6-phosphate-independent endocytosis of beta-glucuronidase by human fibroblasts. I. Evidence for the existence of a membrane-binding activity. , 2001, Biochimica et biophysica acta.

[47]  A. González-Noriega,et al.  Mannose 6-phosphate-independent endocytosis of beta-glucuronidase. II. Purification of a cation-dependent receptor from bovine liver. , 2001, Biochimica et biophysica acta.

[48]  P. Strickland,et al.  Corrigendum: Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1 (Carcinogenesis (1998) 19, (1847-1853)) , 1999 .

[49]  J. H. Kim,et al.  Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. , 1998, Carcinogenesis.

[50]  P. Borm,et al.  Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells. , 1997, Environmental health perspectives.

[51]  L. V. van't Veer,et al.  32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures. , 1997, Mutation research.

[52]  D Hoffmann,et al.  The changing cigarette, 1950-1995. , 1997, Journal of toxicology and environmental health.

[53]  J. Miners,et al.  The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases. , 1993, Carcinogenesis.

[54]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[55]  J H Holbrook,et al.  The changing cigarette. , 1981, The Western journal of medicine.