Activation of the cell stress kinase PKR in Alzheimer’s disease and human amyloid precursor protein transgenic mice

[1]  R. Chang,et al.  Phosphorylation of eukaryotic initiation factor-2&agr; (eIF2&agr;) is associated with neuronal degeneration in Alzheimer's disease , 2002, Neuroreport.

[2]  R. Chang,et al.  Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degeneration , 2002, Journal of neurochemistry.

[3]  D. Scheuner,et al.  Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[4]  S. Salzberg,et al.  Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells , 2001, Oncogene.

[5]  Xiongwei Zhu,et al.  Neurons in Alzheimer disease emerge from senescence , 2001, Mechanisms of Ageing and Development.

[6]  B. Ghetti,et al.  Activation of the JNK/p38 Pathway Occurs in Diseases Characterized by Tau Protein Pathology and Is Related to Tau Phosphorylation But Not to Apoptosis , 2001, Journal of neuropathology and experimental neurology.

[7]  James B. Johnston,et al.  Monocyte activation and differentiation augment human endogenous retrovirus expression: Implications for inflammatory brain diseases , 2001, Annals of neurology.

[8]  S Shimohama,et al.  Activation of MKK6, an upstream activator of p38, in Alzheimer's disease , 2001, Journal of neurochemistry.

[9]  C. Zimmer Do Chronic Diseases Have an Infectious Root? , 2001, Science.

[10]  I. Vincent,et al.  Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer’s disease , 2001, Neuroscience.

[11]  M. Hayden,et al.  Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. , 2001, Human molecular genetics.

[12]  B. Williams Signal Integration via PKR , 2001, Science's STKE.

[13]  K. Herrup,et al.  DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease , 2001, The Journal of Neuroscience.

[14]  Xiongwei Zhu,et al.  Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease , 2001, Journal of neurochemistry.

[15]  Rekha C. Patel,et al.  PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR* , 2000, The Journal of Biological Chemistry.

[16]  Xiongwei Zhu,et al.  Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease , 2000, Neurobiology of Aging.

[17]  T. Arendt Alzheimer’s disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain , 2000, Neurobiology of Aging.

[18]  George Perry,et al.  Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle‐Related Events in Alzheimer Disease , 2000 .

[19]  B. Williams,et al.  The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin , 2000, The EMBO journal.

[20]  S. Kurata Selective Activation of p38 MAPK Cascade and Mitotic Arrest Caused by Low Level Oxidative Stress* , 2000, The Journal of Biological Chemistry.

[21]  Xiongwei Zhu,et al.  Cyclin' toward dementia , 2000, Journal of neuroscience research.

[22]  Xiongwei Zhu,et al.  Activation of oncogenic pathways in degenerating neurons in Alzheimer disease , 2000, International Journal of Developmental Neuroscience.

[23]  Kang Hu,et al.  High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation , 2000, The Journal of Neuroscience.

[24]  C. Plata-salamán,et al.  Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.

[25]  A. Takeda,et al.  Altered cell‐matrix associated ADAM proteins in Alzheimer disease , 2000, Journal of neuroscience research.

[26]  Robert H. Silverman,et al.  Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways , 2000, Molecular and Cellular Biology.

[27]  B. Williams,et al.  PKR; a sentinel kinase for cellular stress , 1999, Oncogene.

[28]  M. Esiri,et al.  Cell cycle-related protein expression in vascular dementia and Alzheimer's disease , 1999, Neuroscience Letters.

[29]  R. Itzhaki,et al.  Herpes simplex virus type 1 and Alzheimer’s disease , 1999, Neurobiology of Aging.

[30]  Mingli Yang,et al.  RAX, a Cellular Activator for Double-stranded RNA-dependent Protein Kinase during Stress Signaling* , 1999, The Journal of Biological Chemistry.

[31]  A. Cuddihy,et al.  The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro , 1999, Oncogene.

[32]  A. Raina,et al.  The role of cell cycle‐mediated events in Alzheimer's disease , 1999, International journal of experimental pathology.

[33]  R. Nicoll,et al.  Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[34]  A. Smith,et al.  The cell division cycle and the pathophysiology of Alzheimer's disease. , 1998, Neuroscience.

[35]  G. Sen,et al.  PACT, a protein activator of the interferon‐induced protein kinase, PKR , 1998, The EMBO journal.

[36]  K. Herrup,et al.  Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain , 1998, The Journal of Neuroscience.

[37]  A. Smith,et al.  Cell cycle markers in the hippocampus in Alzheimer’s disease , 1997, Acta Neuropathologica.

[38]  Philip R. Cohen,et al.  Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases , 1997, FEBS letters.

[39]  A. Smith,et al.  Expression of cell division markers in the hippocampus in Alzheimer’s disease and other neurodegenerative conditions , 1997, Acta Neuropathologica.

[40]  U. Gärtner,et al.  Expression of the cyclin‐dependent kinase inhibitor p16 in Alzheimer's disease , 1996, Neuroreport.

[41]  K. Jellinger,et al.  On the relationship between measles virus and Alzheimer neurofibrillary tangles in subacute sclerosing panencephalitis , 1996, Neurobiology of Aging.

[42]  R. Itzhaki,et al.  Neurotropic viruses and Alzheimer disease , 1996, Molecular and chemical neuropathology.

[43]  P. Ferrante,et al.  PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy , 1995, Journal of medical virology.

[44]  C. Lippa,et al.  Ki‐67 Immunoreactivity in Alzheimer's Disease and Other Neurodegenerative Disorders , 1995, Journal of neuropathology and experimental neurology.

[45]  T. Inagaki,et al.  Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients — a quantitative study , 1992, Acta Neuropathologica.

[46]  Joe C. Adams,et al.  Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. , 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[47]  A. Haase,et al.  Human herpes virus infections and Alzheimer's disease , 1990, Neuropathology and applied neurobiology.

[48]  S. Hirai,et al.  Reexamination of granulovacuolar degeneration , 2004, Acta Neuropathologica.

[49]  I. Ferrer,et al.  Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies , 2001, Journal of Neural Transmission.

[50]  P. Ruvolo Ceramide regulates cellular homeostasis via diverse stress signaling pathways , 2001, Leukemia.

[51]  M. Smith,et al.  Abortive oncogeny and cell cycle-mediated events in Alzheimer disease. , 2000, Progress in cell cycle research.

[52]  T. Arendt,et al.  Aberrancies in signal transduction and cell cycle related events in Alzheimer's disease. , 1998, Journal of neural transmission. Supplementum.

[53]  T. Arendt,et al.  Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease , 1998, Journal of Neural Transmission.

[54]  J. O’Kusky,et al.  In Situ Hybridization Analysis for Herpes Simplex Virus Nucleic Acids in Alzheimer Disease , 1989, Alzheimer disease and associated disorders.