Acute kidney injury in patients with acute coronary syndromes

Acute kidney injury (AKI) is increasingly being seen in patients with acute coronary syndromes (ACSs). This condition has a complex pathogenesis, an incidence that can reach 30% and it is associated with higher short-term and long-term morbidity and mortality. Nevertheless, AKI is still characterised by lack of a single accepted definition, unclear pathophysiology understanding and insensitive diagnostic tools that make its detection difficult, particularly in the setting of ACS. Recent data suggested that patients with AKI during ACS, even those in whom renal function seems to fully recover, face an increased, persisting risk of future AKI and may develop chronic kidney disease. Thus, in these patients, nephrology follow-up, after hospital discharge, and secondary preventive measures should possibly be implemented. In this review, we aim at providing a framework of knowledge to increase cardiologists’ awareness of AKI, with the goal of improving the outcome of patients with ACS.

[1]  F. Veglia,et al.  Prognostic significance of serum creatinine and its change patterns in patients with acute coronary syndromes. , 2015, American heart journal.

[2]  L. Chawla,et al.  Biomarkers of renal function, which and when? , 2015, Clinica chimica acta; international journal of clinical chemistry.

[3]  G. Stone,et al.  Contrast-induced acute kidney injury after primary percutaneous coronary intervention: results from the HORIZONS-AMI substudy. , 2014, European heart journal.

[4]  K. Sugi,et al.  Impact of continuous deterioration of kidney function 6 to 8 months after percutaneous coronary intervention for acute coronary syndrome. , 2014, The American journal of cardiology.

[5]  Y. Arbel,et al.  Renal impairment according to acute kidney injury network criteria among ST elevation myocardial infarction patients undergoing primary percutaneous intervention: a retrospective observational study , 2014, Clinical Research in Cardiology.

[6]  Motohiro Kosugi,et al.  Impact of contrast-induced acute kidney injury on outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. , 2013, Cardiovascular revascularization medicine : including molecular interventions.

[7]  K. Alhabib,et al.  The prognostic impact of in-hospital worsening of renal function in patients with acute coronary syndrome. , 2013, International journal of cardiology.

[8]  Fernando B. Rodrigues,et al.  Incidence and Mortality of Acute Kidney Injury after Myocardial Infarction: A Comparison between KDIGO and RIFLE Criteria , 2013, PloS one.

[9]  C. Geddes,et al.  Acute kidney injury: outcomes and quality of care. , 2013, QJM : monthly journal of the Association of Physicians.

[10]  F. Veglia,et al.  Incidence and relevance of acute kidney injury in patients hospitalized with acute coronary syndromes. , 2013, The American journal of cardiology.

[11]  P. Kimmel,et al.  Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. , 2012, Kidney international.

[12]  M. Leoncini,et al.  Persistent Renal Damage After Contrast-Induced Acute Kidney Injury: Incidence, Evolution, Risk Factors, and Prognosis , 2012, Circulation.

[13]  Fernando B. Rodrigues,et al.  Renal Function at Hospital Admission and Mortality Due to Acute Kidney Injury after Myocardial Infarction , 2012, PloS one.

[14]  Chirag R Parikh,et al.  Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. , 2012, Kidney international.

[15]  Svetlana K. Eden,et al.  Outpatient nephrology referral rates after acute kidney injury. , 2012, Journal of the American Society of Nephrology : JASN.

[16]  K. Alexander,et al.  Short-Term Outcomes of Acute Myocardial Infarction in Patients With Acute Kidney Injury: A Report From the National Cardiovascular Data Registry , 2012, Circulation.

[17]  Norbert Lameire,et al.  Notice , 2012, Kidney International Supplements.

[18]  Jonathan Himmelfarb,et al.  Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. , 2011, Clinical journal of the American Society of Nephrology : CJASN.

[19]  C. Ronco,et al.  The Cardiorenal Syndrome , 2011, International journal of nephrology.

[20]  Min Chul Kim,et al.  Different clinical outcomes of acute kidney injury according to acute kidney injury network criteria in patients between ST elevation and non-ST elevation myocardial infarction. , 2011, International journal of cardiology.

[21]  J. Wi,et al.  Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention , 2011, Heart.

[22]  B. Molitoris,et al.  Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. , 2011, American journal of physiology. Renal physiology.

[23]  M. Tonelli,et al.  Associations Between Acute Kidney Injury and Cardiovascular and Renal Outcomes After Coronary Angiography , 2011, Circulation.

[24]  F. Veglia,et al.  Acute hyperglycemia and contrast-induced nephropathy in primary percutaneous coronary intervention. , 2010, American heart journal.

[25]  J. Spertus,et al.  The prognostic importance of worsening renal function during an acute myocardial infarction on long-term mortality. , 2010, American heart journal.

[26]  S. Ogawa,et al.  Prognostic significance of acute kidney injury after reperfused ST-elevation myocardial infarction: synergistic acceleration of renal dysfunction and left ventricular remodeling. , 2010, Journal of cardiac failure.

[27]  T. Iwasaka,et al.  Contrast-induced nephropathy in patients undergoing emergency percutaneous coronary intervention for acute coronary syndrome. , 2010, The American journal of cardiology.

[28]  F. Veglia,et al.  Acute kidney injury in ST-segment elevation acute myocardial infarction complicated by cardiogenic shock at admission* , 2010, Critical care medicine.

[29]  W. Markiewicz,et al.  The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction. , 2009, Kidney international.

[30]  F. Veglia,et al.  Contrast Volume During Primary Percutaneous Coronary Intervention and Subsequent Contrast-Induced Nephropathy and Mortality , 2009, Annals of Internal Medicine.

[31]  Jonathan Himmelfarb,et al.  Acute kidney injury increases risk of ESRD among elderly. , 2009, Journal of the American Society of Nephrology : JASN.

[32]  Rinaldo Bellomo,et al.  Cardiorenal syndrome. , 2008, Journal of the American College of Cardiology.

[33]  H. Krumholz,et al.  Long-term prognosis of acute kidney injury after acute myocardial infarction. , 2008, Archives of internal medicine.

[34]  J. Allison,et al.  Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. , 2008, Archives of internal medicine.

[35]  Sonal Singh,et al.  A systematic review of patient and health system characteristics associated with late referral in chronic kidney disease , 2008, BMC nephrology.

[36]  D. Basile.  The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. , 2007, Kidney international.

[37]  K. Eagle,et al.  Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome. , 2007, The American journal of cardiology.

[38]  John A Kellum,et al.  Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury , 2007, Critical care.

[39]  F. Veglia,et al.  N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. , 2006, The New England journal of medicine.

[40]  Tom Greene,et al.  Assessing kidney function--measured and estimated glomerular filtration rate. , 2006, The New England journal of medicine.

[41]  Joseph V Bonventre,et al.  Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. , 2005, Journal of the American Society of Nephrology : JASN.

[42]  W. Markiewicz,et al.  Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction. , 2005, American heart journal.

[43]  F. Veglia,et al.  Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction. , 2004, Journal of the American College of Cardiology.

[44]  Philip McFarlane,et al.  Multidisciplinary predialysis care and morbidity and mortality of patients on dialysis. , 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[45]  R. Bellomo,et al.  Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group , 2004, Critical care.

[46]  M. Perazella,et al.  The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease. , 2004, The American journal of medicine.

[47]  A. Nishiyama,et al.  The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure. , 2003, European journal of pharmacology.

[48]  D. Basile,et al.  Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. , 2001, American journal of physiology. Renal physiology.

[49]  J. Grande,et al.  Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult. , 2000, Kidney international.

[50]  N. Madias,et al.  Serum creatinine as an index of renal function: new insights into old concepts. , 1992, Clinical chemistry.