Root perforations: a review of diagnosis, prognosis and materials.

Root perforation results in the communication between root canal walls and periodontal space (external tooth surface). It is commonly caused by an operative procedural accident or pathological alteration (such as extensive dental caries, and external or internal inflammatory root resorption). Different factors may predispose to this communication, such as the presence of pulp stones, calcification, resorptions, tooth malposition (unusual inclination in the arch, tipping or rotation), an extra-coronal restoration or intracanal posts. The diagnosis of dental pulp and/or periapical tissue previous to root perforation is an important predictor of prognosis (including such issues as clinically healthy pulp, inflamed or infected pulp, primary or secondary infection, and presence or absence of intracanal post). Clinical and imaging exams are necessary to identify root perforation. Cone-beam computed tomography constitutes an important resource for the diagnosis and prognosis of this clinical condition. Clinical factors influencing the prognosis and healing of root perforations include its treatment timeline, extent and location. A small root perforation, sealed immediately and apical to the crest bone and epithelial attachment, presents with a better prognosis. The three most widely recommended materials to seal root perforations have been calcium hydroxide, mineral trioxide aggregate and calcium silicate cements. This review aimed to discuss contemporary therapeutic alternatives to treat root canal perforations. Accordingly, the essential aspects for repairing this deleterious tissue injury will be addressed, including its diagnosis, prognosis, and a discussion about the materials actually suggested to seal root canal perforation.

[1]  Z. Fuss,et al.  Root perforations: classification and treatment choices based on prognostic factors. , 1996, Endodontics & dental traumatology.

[2]  J. Camilleri Color stability of white mineral trioxide aggregate in contact with hypochlorite solution. , 2014, Journal of endodontics.

[3]  M. Torabinejad,et al.  Tissue reaction to implanted root-end filling materials in the tibia and mandible of guinea pigs. , 1998, Journal of endodontics.

[4]  P. Parashos,et al.  Coronal tooth discoloration and white mineral trioxide aggregate. , 2013, Journal of endodontics.

[5]  R. Holland,et al.  Reaction of the lateral periodontium of dogs' teeth to contaminated and noncontaminated perforations filled with mineral trioxide aggregate. , 2007, Journal of endodontics.

[6]  R. Frankenberger,et al.  Retrospective evaluation of perforation repairs in 6 private practices. , 2013, Journal of endodontics.

[7]  J. Regan,et al.  Surgical repair of root and tooth perforations , 2005 .

[8]  W. F. Kimbrough,et al.  Sealing ability of mineral trioxide aggregate and super-EBA when used as furcation repair materials: a longitudinal study. , 2002, Journal of endodontics.

[9]  M. Torabinejad,et al.  Using mineral trioxide aggregate as a pulp-capping material. , 1996, Journal of the American Dental Association.

[10]  M. Tanomaru-Filho,et al.  Marginal gingiva discoloration by gray MTA: a case report. , 2007, Journal of endodontics.

[11]  M. Kuga,et al.  pH and calcium ion release of 2 root-end filling materials. , 2003, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[12]  Seema Yadav,et al.  Comparison of physical and mechanical properties of mineral trioxide aggregate and Biodentine. , 2014, Indian journal of dental research : official publication of Indian Society for Dental Research.

[13]  P. Dummer,et al.  Properties and applications of calcium hydroxide in endodontics and dental traumatology. , 2011, International endodontic journal.

[14]  S. Pisanti,et al.  Localization of Calcium Placed over Amputated Pulps in Dogs' Teeth , 1960, Journal of dental research.

[15]  I. Tsesis,et al.  Diagnosis and treatment of accidental root perforations , 2006 .

[16]  M. Torabinejad,et al.  Repair of root perforations using mineral trioxide aggregate: a long-term study. , 2004, Journal of endodontics.

[17]  J. Camilleri,et al.  Investigation of the physical properties of tricalcium silicate cement-based root-end filling materials. , 2013, Dental materials : official publication of the Academy of Dental Materials.

[18]  M. Torabinejad,et al.  Mineral trioxide aggregate: a comprehensive literature review--part II: leakage and biocompatibility investigations. , 2010, Journal of endodontics.

[19]  D. Saure,et al.  Treatment outcome of mineral trioxide aggregate: repair of root perforations-long-term results. , 2014, Journal of endodontics.

[20]  M. Torabinejad,et al.  Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations. , 1993, Journal of endodontics.

[21]  R. Holland,et al.  Healing process of dog dental pulp after pulpotomy and pulp covering with mineral trioxide aggregate or Portland cement. , 2001, Brazilian dental journal.

[22]  E. Whaites,et al.  The potential applications of cone beam computed tomography in the management of endodontic problems. , 2007, International endodontic journal.

[23]  E Tammisalo,et al.  Development of a compact computed tomographic apparatus for dental use. , 1999, Dento maxillo facial radiology.

[24]  M. Torabinejad,et al.  Osteoblast biocompatibility of mineral trioxide aggregate. , 1999, Biomaterials.

[25]  D. Damidot,et al.  Characterization of un-hydrated and hydrated BioAggregate™ and MTA Angelus™ , 2014, Clinical Oral Investigations.

[26]  R. Holland,et al.  Calcium salts deposition in rat connective tissue after the implantation of calcium hydroxide-containing sealers. , 2002, Journal of endodontics.

[27]  E. Nicholls Treatment of traumatic perforations of the pulp cavity. , 1962, Oral surgery, oral medicine, and oral pathology.

[28]  A. Fouad,et al.  Interfacial characteristics of Biodentine and MTA with dentine in simulated body fluid. , 2015, Journal of dentistry.

[29]  T. Attin,et al.  Tooth discoloration induced by endodontic materials: a laboratory study. , 2012, International endodontic journal.

[30]  P. Dummer,et al.  Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II other clinical applications and complications , 2018, International endodontic journal.

[31]  F. Al Resorption, perforations, and fractures. , 1974 .

[32]  B. Pellat,et al.  Effect of a Calcium-silicate-based Restorative Cement on Pulp Repair , 2012, Journal of dental research.

[33]  T. Hulland Selected Histochemical and Histopathological Methods , 1967 .

[34]  P. Parashos,et al.  Adaptation of mineral trioxide aggregate to dentine walls compared with other root‐end filling materials: A systematic review , 2019, Australian endodontic journal : the journal of the Australian Society of Endodontology Inc.

[35]  A. Farman,et al.  Clinical applications of cone-beam computed tomography in dental practice. , 2006, Journal.

[36]  A. L. Frank Resorption, perforations, and fractures. , 1974, Dental clinics of North America.

[37]  Marcel E Noujeim,et al.  Influence of the Beam Hardness on Artifacts in Cone-Beam CT , 2008 .

[38]  M. Torabinejad,et al.  Repair of furcal perforations with mineral trioxide aggregate: two case reports. , 1996, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[39]  Jens Dreyhaupt,et al.  Treatment outcome of mineral trioxide aggregate: repair of root perforations. , 2010, Journal of endodontics.

[40]  C. Estrela,et al.  Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. , 1995, Brazilian dental journal.

[41]  E. T. Koh,et al.  Mineral trioxide aggregate stimulates a biological response in human osteoblasts. , 1997, Journal of biomedical materials research.

[42]  C. Estrela,et al.  Three-dimensional image contribution for evaluation of operative procedural errors in endodontic therapy and dental implants. , 2012, Brazilian dental journal.

[43]  M. Torabinejad,et al.  Bacterial leakage of mineral trioxide aggregate as a root-end filling material. , 1995, Journal of endodontics.

[44]  R. Holland,et al.  Mineral trioxide aggregate repair of lateral root perforations. , 2001, Journal of endodontics.

[45]  J. Gutmann,et al.  Radiopacifier particle size impacts the physical properties of tricalcium silicate-based cements. , 2015, Journal of endodontics.

[46]  J. Camilleri Hydration mechanisms of mineral trioxide aggregate. , 2007, International endodontic journal.

[47]  H. Stanley,et al.  Dentistry's friend: calcium hydroxide. , 1997, Operative dentistry.

[48]  M. Wheater,et al.  Cytotoxicity comparison of mineral trioxide aggregates and EndoSequence bioceramic root repair materials. , 2011, Journal of endodontics.

[49]  J. D. PÉcora,et al.  Characterization of successful root canal treatment. , 2014, Brazilian dental journal.

[50]  M. Kuga,et al.  Arsenic release provided by MTA and Portland cement. , 2005, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[51]  L. Tronstad,et al.  Long-term calcium hydroxide treatment of a tooth with iatrogenic root perforation and lateral periodontitis. , 1985, Endodontics & dental traumatology.

[52]  P. Mozzo,et al.  A new volumetric CT machine for dental imaging based on the cone-beam technique: preliminary results , 1998, European Radiology.

[53]  W. Oh,et al.  Cytotoxicity and physical properties of tricalcium silicate-based endodontic materials , 2014, Restorative dentistry & endodontics.

[54]  J. Andreasen,et al.  pH changes in dental tissues after root canal filling with calcium hydroxide. , 1981, Journal of endodontics.

[55]  Francisco José de Souza-Filho,et al.  Microbial susceptibility to calcium hydroxide pastes and their vehicles. , 2002, Journal of endodontics.

[56]  C. Estrela,et al.  Antimicrobial evaluation of calcium hydroxide in infected dentinal tubules. , 1999, Journal of endodontics.

[57]  S. Seltzer,et al.  Periodontal Effects of Root Perforations Before and During Endodontic Procedures , 1970, Journal of dental research.

[58]  J. E. Gomes-Filho,et al.  Histological evaluation of MTA as a root-end filling material. , 2007, International endodontic journal.

[59]  Zhejun Wang Bioceramic materials in endodontics , 2015 .

[60]  A. Katsumata,et al.  Image artifact in dental cone-beam CT. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[61]  R. Holland,et al.  Root canal treatment with calcium hydroxide. II. Effect of instrumentation beyond the apices. , 1979, Oral surgery, oral medicine, and oral pathology.

[62]  M. Torabinejad,et al.  Tissue reaction to implanted super-EBA and mineral trioxide aggregate in the mandible of guinea pigs: a preliminary report. , 1995, Journal of endodontics.

[63]  J. Camilleri,et al.  Mineral trioxide aggregate: a review of the constituents and biological properties of the material. , 2006, International endodontic journal.

[64]  M. Duarte,et al.  Assessment of color stability of white mineral trioxide aggregate angelus and bismuth oxide in contact with tooth structure. , 2014, Journal of endodontics.

[65]  J. Granjeiro,et al.  Cytocompatibility of the ready-to-use bioceramic putty repair cement iRoot BP Plus with primary human osteoblasts. , 2012, International endodontic journal.

[66]  R. Lemon Nonsurgical repair of perforation defects. Internal matrix concept. , 1992, Dental clinics of North America.

[67]  Khojasteh,et al.  Diagnostic Accuracy of Cone-beam Computed Tomography and Conventional Periapical Radiography in Detecting Strip Root Perforations , 2016, Journal of International Oral Health.

[68]  G. Cheung,et al.  Treatment Outcome of Repaired Root Perforation: A Systematic Review and Meta-analysis. , 2015, Journal of endodontics.

[69]  G. Heithersay Periapical repair following conservative endodontic therapy. , 1970, Australian dental journal.

[70]  D. Hartmann,et al.  Odontoblast-like cytodifferentiation of human dental pulp cells in vitro in the presence of a calcium hydroxide-containing cement. , 1991, Archives of oral biology.

[71]  G. Gavini,et al.  Evaluation of radiopacity, pH, release of calcium ions, and flow of a bioceramic root canal sealer. , 2012, Journal of endodontics.

[72]  V. Himel,et al.  Evaluation of repair of mechanical perforations of the pulp chamber floor using biodegradable tricalcium phosphate or calcium hydroxide. , 1985, Journal of endodontics.

[73]  R. Holland,et al.  A comparison of one versus two appointment endodontic therapy in dogs' teeth with apical periodontitis. , 2003, Journal of endodontics.

[74]  M. Haapasalo,et al.  Dentin enhances the antibacterial effect of mineral trioxide aggregate and bioaggregate. , 2009, Journal of endodontics.

[75]  C. Estrela,et al.  In vitro determination of direct antimicrobial effect of calcium hydroxide. , 1998, Journal of endodontics.

[76]  Mahmoud Torabinejad,et al.  Mineral trioxide aggregate: a comprehensive literature review--Part I: chemical, physical, and antibacterial properties. , 2010, Journal of endodontics.

[77]  J. Wealleans,et al.  Effect of 3 Bioceramic Materials on Stem Cells of the Apical Papilla Proliferation and Differentiation Using a Dentin Disk Model , 2018, Journal of endodontics.

[78]  Y. Boucher,et al.  Analysis of reasons for extraction of endodontically treated teeth: a prospective study. , 2011, Journal of endodontics.

[79]  G. Heithersay,et al.  Calcium hydroxide in the treatment of pulpless teeth with associated pathology. , 1975, Journal of the British Endodontic Society.

[80]  A. Wucherpfennig,et al.  PR 40 Mineral Trioxide vs. Portland Cement: Two biocompatible filling materials , 1999 .

[81]  M Torabinejad,et al.  Investigation of mineral trioxide aggregate for root-end filling in dogs. , 1995, Journal of endodontics.

[82]  J F Siqueira,et al.  Disinfection by calcium hydroxide pastes of dentinal tubules infected with two obligate and one facultative anaerobic bacteria. , 1996, Journal of endodontics.

[83]  M. Torabinejad,et al.  Physical and chemical properties of a new root-end filling material. , 1995, Journal of endodontics.

[84]  S. Pisanti,et al.  Origin of Calcium in the Repair Wall after Pulp Exposure in the Dog , 1964, Journal of dental research.

[85]  M. Mizuno,et al.  Calcium ion release from calcium hydroxide stimulated fibronectin gene expression in dental pulp cells and the differentiation of dental pulp cells to mineralized tissue forming cells by fibronectin. , 2008, International endodontic journal.

[86]  R. Holland,et al.  Root canal treatment with calcium hydroxide. III. Effect of debris and pressure filling. , 1979, Oral surgery, oral medicine, and oral pathology.

[87]  E. Reynolds,et al.  Calcium silicate‐based cements: composition, properties, and clinical applications , 2017, Journal of investigative and clinical dentistry.

[88]  M. Torabinejad,et al.  Dye leakage of four root end filling materials: effects of blood contamination. , 1994, Journal of endodontics.

[89]  M. Trope,et al.  Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? , 2004, Journal of endodontics.

[90]  Oswald Rj Procedural accidents and their repair. , 1979 .

[91]  R. Oswald Procedural accidents and their repair. , 1979, Dental clinics of North America.

[92]  Scott A Schwartz,et al.  Endodontic applications of cone-beam volumetric tomography. , 2007, Journal of endodontics.

[93]  R. Holland,et al.  Ability of a new calcium hydroxide root canal filling material to induce hard tissue formation. , 1985, Journal of endodontics.

[94]  R. Curtis,et al.  The constitution of mineral trioxide aggregate. , 2005, Dental materials : official publication of the Academy of Dental Materials.

[95]  H. Gerth,et al.  Chemical and physical surface and bulk material characterization of white ProRoot MTA and two Portland cements. , 2005, Dental materials : official publication of the Academy of Dental Materials.

[96]  J. Baumgartner,et al.  Perforation repair comparing two types of mineral trioxide aggregate. , 2004, Journal of endodontics.

[97]  M. Matsumoto,et al.  Zinc Oxide Inhibits Dental Discoloration Caused by White Mineral Trioxide Aggregate Angelus , 2017, Journal of endodontics.

[98]  S. Seltzer,et al.  Endodontic failures--an analysis based on clinical, roentgenographic, and histologic findings. II. , 1967, Oral surgery, oral medicine, and oral pathology.

[99]  C. Estrela,et al.  Factors affecting the periapical healing process of endodontically treated teeth , 2017, Journal of applied oral science : revista FOB.

[100]  Carlos Estrela,et al.  A new periapical index based on cone beam computed tomography. , 2008, Journal of endodontics.

[101]  R. Holland,et al.  Reaction of rat connective tissue to implanted dentin tube filled with mineral trioxide aggregate, Portland cement or calcium hydroxide. , 2001, Brazilian dental journal.

[102]  L. I. Grossman,et al.  ROENTGENOLOGIC AND CLINICAL EVALUATION OF ENDODONTICALLY TREATED TEETH. , 1964, Oral surgery, oral medicine, and oral pathology.

[103]  A. Kaufman,et al.  Conservative treatment of root perforations using apex locator and thermatic compactor--case study of a new method. , 1989, Journal of endodontics.

[104]  H. Alhadainy Root perforations. A review of literature. , 1994, Oral surgery, oral medicine, and oral pathology.

[105]  R. Holland,et al.  Reaction of human periapical tissue to pulp extirpation and immediate root canal filling with calcium hydroxide. , 1977, Journal of endodontics.

[106]  J. D. PÉcora,et al.  Effect of vehicle on antimicrobial properties of calcium hydroxide pastes. , 1999, Brazilian dental journal.

[107]  Ehab El Sayed Hassanien,et al.  ProRoot MTA, MTA-Angelus and IRM used to repair large furcation perforations: sealability study. , 2008, Journal of endodontics.

[108]  Carlos Estrela,et al.  Accuracy of cone beam computed tomography and panoramic and periapical radiography for detection of apical periodontitis. , 2008, Journal of endodontics.

[109]  R. Holland,et al.  Calcium hydroxide and a corticosteroid-antibiotic association as dressings in cases of biopulpectomy. A comparative study in dogs' teeth. , 1998, Brazilian dental journal.

[110]  R. Holland,et al.  Reaction of rat connective tissue to implanted dentin tubes filled with mineral trioxide aggregate or calcium hydroxide. , 1999, Journal of endodontics.

[111]  E. Z. Chong,et al.  Dentin-cement Interfacial Interaction , 2012, Journal of dental research.

[112]  Carlos Estrela,et al.  Map-reading strategy to diagnose root perforations near metallic intracanal posts by using cone beam computed tomography. , 2011, Journal of endodontics.

[113]  P. Nelson-Filho,et al.  Furcation Perforation: Periradicular Tissue Response to Biodentine as a Repair Material by Histopathologic and Indirect Immunofluorescence Analyses , 2017, Journal of endodontics.

[114]  Á. Borges,et al.  Evaluation of physico-chemical properties of Portland cements and MTA. , 2010, Brazilian oral research.

[115]  Carlos Estrela,et al.  Common Operative Procedural Errors and Clinical Factors Associated with Root Canal Treatment. , 2017, Brazilian dental journal.

[116]  R. Holland,et al.  Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate. , 2002, Brazilian dental journal.

[117]  M. Torabinejad,et al.  Histologic assessment of mineral trioxide aggregate as a root-end filling in monkeys. , 1997, Journal of endodontics.

[118]  Riccardo Pace,et al.  Mineral trioxide aggregate as repair material for furcal perforation: case series. , 2008, Journal of endodontics.

[119]  M. Torabinejad,et al.  Use of mineral trioxide aggregate for repair of furcal perforations. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[120]  R. S. Roda Root perforation repair: surgical and nonsurgical management. , 2001, Practical procedures & aesthetic dentistry : PPAD.

[121]  J. D. PÉcora,et al.  Antimicrobial and chemical study of MTA, Portland cement, calcium hydroxide paste, Sealapex and Dycal. , 2000, Brazilian dental journal.

[122]  T. Komabayashi,et al.  Particle size and shape analysis of MTA finer fractions using Portland cement. , 2008, Journal of endodontics.

[123]  A. Farman,et al.  What is cone-beam CT and how does it work? , 2008, Dental clinics of North America.

[124]  D. F. Mitchell,et al.  Osteogenic Potential of Calcium Hydroxide and Other Materials in Soft Tissue and Bone Wounds , 1958, Journal of dental research.

[125]  M. Torabinejad,et al.  Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action. , 2010, Journal of endodontics.

[126]  R. Holland,et al.  Root canal treatment with calcium hydroxide. I. Effect of overfilling and refilling. , 1979, Oral surgery, oral medicine, and oral pathology.

[127]  Qiang Zhu,et al.  Cell and tissue reactions to mineral trioxide aggregate and Portland cement. , 2003, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[128]  I. G. de Moraes,et al.  Radiopacity of portland cement associated with different radiopacifying agents. , 2009, Journal of endodontics.

[129]  M. Tanomaru-Filho,et al.  Evaluation of the propylene glycol association on some physical and chemical properties of mineral trioxide aggregate. , 2012, International endodontic journal.

[130]  T R Pitt Ford,et al.  Sealing ability of a mineral trioxide aggregate when used as a root end filling material. , 1993, Journal of endodontics.

[131]  C. Sedgley,et al.  Antibacterial activity of endosequence root repair material and proroot MTA against clinical isolates of Enterococcus faecalis. , 2011, Journal of endodontics.

[132]  A. L. Frank,et al.  Nonsurgical therapy for the perforative defect of internal resorption. , 1973, Journal of the American Dental Association.

[133]  Treatment outcome in endodontics: the Toronto study. Phases I and II: Orthograde retreatment. , 2004 .

[134]  Stanley Hr,et al.  Dentistry's friend: calcium hydroxide. , 1997 .

[135]  Paul R Wesselink,et al.  The use of cone-beam computed tomography and digital periapical radiographs to diagnose root perforations. , 2011, Journal of endodontics.

[136]  Su-Jung Shin,et al.  Repair of perforations with MTA: clinical applications and mechanisms of action , 2006 .

[137]  M. Torabinejad Clinical applications of mineral trioxide aggregate. , 1999, The Alpha omegan.

[138]  J H Siewerdsen,et al.  Technical aspects of dental CBCT: state of the art. , 2015, Dento maxillo facial radiology.

[139]  Z. Fuss,et al.  Reliability of different electronic apex locators to detect root perforations in vitro. , 1997, International endodontic journal.