Noninvasive blood glucose sensors based on near-infrared spectroscopy.

Research into noninvasive devices for self-monitoring of blood glucose is mainly based on near-infrared spectroscopy. Such a device is particularly desirable in the intensive therapy of patients with diabetes mellitus to achieve optimal metabolic control through frequent glucose testing. The state of noninvasive assay technology is presented. Using diffuse reflectance spectra of mucous lip tissue has advantages and drawbacks compared with tissue transmittance experiments. Different approaches have been proposed in the patent literature; however, current technology requires further significant improvements, particularly within the lower normal and hypoglycemic glucose concentration ranges.

[1]  H. M. Heise,et al.  On the efficiency of algorithms for multivariate linear calibration used in analytical spectroscopy , 1992 .

[2]  Halina Barańska,et al.  Making light work: Advances in near infrared spectroscopy , 1993 .

[3]  H. Heise,et al.  Noninvasive Blood Glucose Assay by Near-Infrared Diffuse Reflectance Spectroscopy of the Human Inner Lip , 1993 .

[4]  H. A. Ferwerda,et al.  Scattering and absorption of turbid materials determined from reflection measurements. 1: theory. , 1983, Applied optics.

[5]  P. Jansson,et al.  Characterization by microdialysis of intracellular glucose level in subcutaneous tissue in humans. , 1988, The American journal of physiology.

[6]  H. M. Heise,et al.  Novel design of an ellipsoidal diffuse-reflectance accessory with improved throughput , 1992, Other Conferences.

[7]  E. V. Thomas,et al.  Noninvasive glucose monitoring in diabetic patients: a preliminary evaluation. , 1992, Clinical chemistry.

[8]  H. M. Heise,et al.  Multivariate determination of blood substrates in human plasma by FT-NIR spectroscopy , 1992, Other Conferences.

[9]  H. M. Heise,et al.  Effect of data pretreatment on the noninvasive blood glucose measurement by diffuse reflectance NIR spectroscopy , 1994, Other Conferences.

[10]  David M. Haaland,et al.  Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration , 1992 .

[11]  T. Koschinsky,et al.  New Approach to Technical and Clinical Evaluation of Devices for Self-Monitoring of Blood Glucose , 1988, Diabetes Care.