Chromosome size-dependent control of meiotic recombination.

Smaller chromosomes have higher rates of meiotic reciprocal recombination (centimorgans per kilobase pair) than larger chromosomes. This report demonstrates that decreasing the size of Saccharomyces cerevisiae chromosomal DNA molecules increases rates of meiotic recombination and increasing chromosome size decreases recombination rates. These results indicate that chromosome size directly affects meiotic reciprocal recombination.

[1]  H. Bussey,et al.  Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcrioptional regulator in the DNA sequence of an 8·6 kb region in the LTE1‐CYS1 interval on the left arm of chormosome I , 1992, Yeast.

[2]  N E Morton,et al.  Parameters of the human genome. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M V Olson,et al.  Physical map of the Saccharomyces cerevisiae genome at 110-kilobase resolution. , 1991, Genetics.

[4]  V. Guacci,et al.  Distributive disjunction of authentic chromosomes in Saccharomyces cerevisiae. , 1991, Genetics.

[5]  D. Kaback,et al.  Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene. , 1990, Gene.

[6]  J A Kans,et al.  Genetic map of Saccharomyces cerevisiae, edition 10 , 1989, Yeast.

[7]  H. Y. Steensma,et al.  Enhanced meiotic recombination on the smallest chromosome of Saccharomyces cerevisiae. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[8]  B. Tye,et al.  Meiotic disjunction of homologs in Saccharomyces cerevisiae is directed by pairing and recombination of the chromosome arms but not by pairing of the centromeres. , 1988, Genetics.

[9]  R. W. Davis,et al.  Recombinational substrates designed to study recombination between unique and repetitive sequences in vivo. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[10]  W. Brown,et al.  Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal , 1985, Nature.

[11]  K. G. Coleman,et al.  Temperature-sensitive lethal mutations on yeast chromosome I appear to define only a small number of genes. , 1984, Genetics.

[12]  John Carbon,et al.  Isolation of a yeast centromere and construction of functional small circular chromosomes , 1980, Nature.

[13]  D. Botstein,et al.  Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[14]  B. S. Baker,et al.  The genetic control of meiosis. , 1976, Annual review of genetics.

[15]  D. D. Perkins.  The manifestation of chromosome rearrangements in unordered asci of Neurospora. , 1974, Genetics.

[16]  D. D. Perkins.  Biochemical Mutants in the Smut Fungus Ustilago Maydis. , 1949, Genetics.