Metabolic Interactions in the Tumor Microenvironment.

[1]  J. Marini,et al.  Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism. , 2017, Metabolic engineering.

[2]  Xenia Geeraerts,et al.  Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity , 2017, Front. Immunol..

[3]  J. Xavier,et al.  Metabolic origins of spatial organization in the tumor microenvironment , 2017, Proceedings of the National Academy of Sciences.

[4]  T. Horng,et al.  Metabolism Supports Macrophage Activation , 2017, Front. Immunol..

[5]  E. Collisson,et al.  Stromal cues regulate the pancreatic cancer epigenome and metabolome , 2017, Proceedings of the National Academy of Sciences.

[6]  D. Fazakerley,et al.  Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration , 2017, Cancer & metabolism.

[7]  A. Saghatelian,et al.  Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis , 2017, Proceedings of the National Academy of Sciences.

[8]  D. Anastasiou.  Tumour microenvironment factors shaping the cancer metabolism landscape , 2016, British Journal of Cancer.

[9]  Prahlad T. Ram,et al.  Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. , 2016, Cell metabolism.

[10]  K. Vousden,et al.  The Quid Pro Quo of the Tumor/Stromal Interaction. , 2016, Cell metabolism.

[11]  S. Haferkamp,et al.  LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. , 2016, Cell metabolism.

[12]  M. Karin,et al.  p62 in Cancer: Signaling Adaptor Beyond Autophagy , 2016, Cell.

[13]  J. Rathmell,et al.  Nutrients and the microenvironment to feed a T cell army. , 2016, Seminars in immunology.

[14]  Joerg M. Buescher,et al.  Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis. , 2016, Cell reports.

[15]  M. Mann,et al.  L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity , 2016, Cell.

[16]  M. Belvin,et al.  Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. , 2016, Nature chemical biology.

[17]  Purushottam D. Dixit,et al.  Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers , 2016, Science.

[18]  R. Kalluri.  The biology and function of fibroblasts in cancer , 2016, Nature Reviews Cancer.

[19]  L. Cantley,et al.  Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion , 2016, Nature.

[20]  R. Jain,et al.  Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. , 2016, Cancer discovery.

[21]  C. Iacobuzio-Donahue,et al.  Pancreatic cancer biology and genetics from an evolutionary perspective , 2016, Nature Reviews Cancer.

[22]  V. Imbert,et al.  Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. , 2016, Blood.

[23]  F. Di Virgilio,et al.  Extracellular purines, purinergic receptors and tumor growth , 2016, Oncogene.

[24]  Alexandra R. Washabaugh,et al.  Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer , 2016, Biochemistry and biophysics reports.

[25]  S. Hingorani,et al.  Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma. , 2016, Gastroenterology.

[26]  R. Kuick,et al.  Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer , 2016, Cell.

[27]  Paolo P. Provenzano,et al.  Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase. , 2016, Biophysical journal.

[28]  D. Hanahan,et al.  Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling , 2016, Cell reports.

[29]  Prahlad T. Ram,et al.  Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism , 2016, eLife.

[30]  B. Faubert,et al.  Metabolic Heterogeneity in Human Lung Tumors , 2016, Cell.

[31]  J. Hutcheson,et al.  Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease , 2016, Clinical Cancer Research.

[32]  Abhishek K. Jha,et al.  Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. , 2016, Cell metabolism.

[33]  P. Murray.  Amino acid auxotrophy as a system of immunological control nodes , 2016, Nature Immunology.

[34]  S. Kasparov.  Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain? , 2016, Cell metabolism.

[35]  N. Pavlova,et al.  The Emerging Hallmarks of Cancer Metabolism. , 2016, Cell metabolism.

[36]  Eytan Ruppin,et al.  Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma , 2015, Nature Cell Biology.

[37]  G. Christofori,et al.  Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy , 2015, Cell reports.

[38]  C. Heeschen,et al.  MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells. , 2015, Cell metabolism.

[39]  R. Schreiber,et al.  Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression , 2015, Cell.

[40]  J. Locasale,et al.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses , 2015, Cell.

[41]  Doriane Lorendeau,et al.  Metabolic control of signalling pathways and metabolic auto‐regulation , 2015, Biology of the cell.

[42]  Sang J. Chung,et al.  A Lactate-Induced Response to Hypoxia , 2015, Cell.

[43]  J. Mi,et al.  Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation. , 2015, Cell reports.

[44]  V. Paradis,et al.  Obesity and Fatty Pancreatic Infiltration Are Risk Factors for Pancreatic Precancerous Lesions (PanIN) , 2015, Clinical Cancer Research.

[45]  A. Lane,et al.  Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. , 2015, The Journal of clinical investigation.

[46]  M. V. Vander Heiden,et al.  Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. , 2015, Cancer research.

[47]  A. Klopp,et al.  Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells. , 2015, Cancer research.

[48]  P. Thevenot,et al.  l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. , 2015, Cancer research.

[49]  David A. Eccles,et al.  Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. , 2015, Cell metabolism.

[50]  Lucas B. Sullivan,et al.  Mitochondrial reactive oxygen species and cancer , 2014, Cancer & Metabolism.

[51]  R. Kalluri,et al.  PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis , 2014, Nature Cell Biology.

[52]  John M. Asara,et al.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function , 2014, Nature.

[53]  Christian M. Metallo,et al.  Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. , 2014, Cancer cell.

[54]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[55]  R. Jain,et al.  The role of mechanical forces in tumor growth and therapy. , 2014, Annual review of biomedical engineering.

[56]  M. Idzko,et al.  Nucleotide signalling during inflammation , 2014, Nature.

[57]  D. Sabatini,et al.  Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides , 2014, Nature.

[58]  C. Roland,et al.  A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. , 2013, Gastroenterology.

[59]  L. Antonioli,et al.  Immunity, inflammation and cancer: a leading role for adenosine , 2013, Nature Reviews Cancer.

[60]  J. Bhattacharya,et al.  When cells become organelle donors. , 2013, Physiology.

[61]  A. Halestrap.  Monocarboxylic acid transport. , 2013, Comprehensive Physiology.

[62]  H. Schreiber,et al.  Innate and adaptive immune cells in the tumor microenvironment , 2013, Nature Immunology.

[63]  M. Dewhirst,et al.  Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer , 2013, PloS one.

[64]  J. Cleveland,et al.  Targeting lactate metabolism for cancer therapeutics. , 2013, The Journal of clinical investigation.

[65]  Z. Husain,et al.  Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells , 2013, The Journal of Immunology.

[66]  C. Collins,et al.  Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? , 2013, The Journal of pathology.

[67]  L. Cantley,et al.  Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance , 2013, Cell cycle.

[68]  A. Kazlauskas,et al.  Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis* , 2013, The Journal of Biological Chemistry.

[69]  R. Vonderheide,et al.  Inflammatory networks and immune surveillance of pancreatic carcinoma. , 2013, Current opinion in immunology.

[70]  O. Elemento,et al.  Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor , 2013, Molecular Cancer Research.

[71]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[72]  R. Tomasini,et al.  Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma , 2013, Proceedings of the National Academy of Sciences.

[73]  W. Wick,et al.  Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. , 2012, Cancer research.

[74]  J. Verrax,et al.  Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells , 2012, PloS one.

[75]  E. Giannoni,et al.  Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. , 2012, Cancer research.

[76]  G. Dienel,et al.  Brain Lactate Metabolism: The Discoveries and the Controversies , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[77]  Pierre J Magistretti,et al.  Sweet Sixteen for ANLS , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[78]  R. Schwarcz,et al.  Kynurenines in the mammalian brain: when physiology meets pathology , 2012, Nature Reviews Neuroscience.

[79]  Alessia Ricupito,et al.  Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. , 2012, Cancer research.

[80]  M. Fukuda,et al.  Faculty Opinions recommendation of Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. , 2012 .

[81]  D. Gabrilovich,et al.  Coordinated regulation of myeloid cells by tumours , 2012, Nature Reviews Immunology.

[82]  J. Koutcher,et al.  Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. , 2012, Experimental cell research.

[83]  T. Fan,et al.  The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. , 2012, Cell metabolism.

[84]  F. Sotgia,et al.  Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. , 2012, Annual review of pathology.

[85]  C. Croce,et al.  Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukemia , 2012, Nature Cell Biology.

[86]  S. Dangi‐Garimella,et al.  Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice , 2012, Gut.

[87]  G. Mills,et al.  Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth , 2011, Nature Medicine.

[88]  O. Feron,et al.  Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments , 2011, Disease Models & Mechanisms.

[89]  M. Weller,et al.  An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor , 2011, Nature.

[90]  P. Carmeliet,et al.  Molecular mechanisms and clinical applications of angiogenesis , 2011, Nature.

[91]  F. Végran,et al.  Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. , 2011, Cancer research.

[92]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[93]  Kun-Liang Guan,et al.  Regulation of intermediary metabolism by protein acetylation. , 2011, Trends in biochemical sciences.

[94]  P. Magistretti,et al.  Astrocyte–neuron metabolic relationships: for better and for worse , 2011, Trends in Neurosciences.

[95]  Kazuya Masuda,et al.  Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism , 2010, Proceedings of the National Academy of Sciences.

[96]  J. Fechner,et al.  An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells , 2010, The Journal of Immunology.

[97]  Z. Werb,et al.  Tumors as organs: complex tissues that interface with the entire organism. , 2010, Developmental cell.

[98]  P. Fortina,et al.  The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma , 2009, Cell cycle.

[99]  H. Pitt,et al.  Obesity potentiates the growth and dissemination of pancreatic cancer. , 2009, Surgery.

[100]  Frank Y. S. Chuang,et al.  Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. , 2009, Cancer research.

[101]  Julien Verrax,et al.  Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. , 2008, The Journal of clinical investigation.

[102]  Joseph M. Galante,et al.  Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase , 2008, International journal of cancer.

[103]  J. Lasky,et al.  Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[104]  D. Munn,et al.  Creating immune privilege: active local suppression that benefits friends, but protects foes , 2008, Nature Reviews Immunology.

[105]  V. Kuchroo,et al.  Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression , 2007, The Journal of experimental medicine.

[106]  D. Quiceno,et al.  L-arginine availability regulates T-lymphocyte cell-cycle progression. , 2007, Blood.

[107]  Pál Pacher,et al.  Adenosine receptors: therapeutic aspects for inflammatory and immune diseases , 2006, Nature Reviews Drug Discovery.

[108]  D. Puro,et al.  Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. , 2006, American journal of physiology. Heart and circulatory physiology.

[109]  G. Burnstock.  Pathophysiology and Therapeutic Potential of Purinergic Signaling , 2006, Pharmacological Reviews.

[110]  Darwin J. Prockop,et al.  Mitochondrial transfer between cells can rescue aerobic respiration , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[111]  Adrian L Harris,et al.  Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. , 2006, Cancer research.

[112]  B. Baban,et al.  GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. , 2005, Immunity.

[113]  R. Jain.  Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[114]  J. Ochoa,et al.  l-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes1 , 2003, The Journal of Immunology.

[115]  A. Ohta,et al.  Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage , 2001, Nature.

[116]  D. Munn,et al.  Inhibition of  T Cell Proliferation by Macrophage Tryptophan Catabolism , 1999, The Journal of experimental medicine.

[117]  D. Munn,et al.  Prevention of allogeneic fetal rejection by tryptophan catabolism. , 1998, Science.

[118]  J. Blay,et al.  The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. , 1997, Cancer research.

[119]  P. Felig.  The glucose-alanine cycle. , 1973, Metabolism: clinical and experimental.