Symptoms in relation to chemicals and dampness in newly built dwellings

Objectives: As the airtightness of dwellings has recently increased, problems associated with indoor air pollution and dampness have become important environmental health issues. The aim of this study was to clarify whether symptoms in residents living in newly built dwellings were related to chemicals and dampness. Methods: Symptoms of 317 residents were surveyed by standardized questionnaires, and the concentrations of formaldehyde, acetaldehyde, and 17 volatile organic compounds (VOCs) in their homes were measured. Dampness (condensation on window panes and/or walls, and mold growth) was identified by questionnaires given to the householders or their partners. Results: Some VOCs (toluene, butyl acetate, ethylbenzene, alpha-pinene, p-dichlorobenzene, nonanal, and xylene) were significantly related to the symptoms, and the sum of all VOCs (all identified VOCs) was significantly related to throat and respiratory symptoms [odds ratio (OR) for eye symptoms =2.4; 95% confidence interval (CI) 1.0–5.5], although the concentrations of VOCs were relatively low. As for the dampness index, condensation on window panes and/or walls was related to all symptoms, and mold growth was related to all symptoms except skin, throat and respiratory and general symptoms. As the number of dampness signs increased, the ORs increased for the symptoms except general symptoms (OR for nose symptoms = 4.4, 95% CI 1.6–11.9). Conclusion: Both VOCs and dampness were significantly related to symptoms. We should take measures to reduce the concentrations of VOCs, dampness and microbial growth in dwellings.

[1]  D. Main,et al.  Health effects of low-level exposure to formaldehyde. , 1983, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[2]  B Wessén,et al.  Microbial volatile organic compounds--what substances can be found in sick buildings? , 1996, The Analyst.

[3]  L. Mølhave Controlled Experiments for Studies of the Sick Building Syndrome , 1992, Annals of the New York Academy of Sciences.

[4]  S. Kohno,et al.  Nasal hyperresponsiveness to histamine induced by repetitive exposure to cedar pollen in guinea-pigs. , 1999, The European respiratory journal.

[5]  Geo Clausen,et al.  TVOC and Health in Non-industrial Indoor Environments , 1997 .

[6]  C. Baines,et al.  Multiple Chemical Sensitivity: Discriminant Validity of Case Definitions , 2001, Archives of environmental health.

[7]  T. Mizoue,et al.  Environmental tobacco smoke exposure and overtime work as risk factors for sick building syndrome in Japan. , 2001, American journal of epidemiology.

[8]  D Norbäck,et al.  Sick building syndrome in relation to building dampness in multi-family residential buildings in Stockholm , 2001, International archives of occupational and environmental health.

[9]  Judy Sparer,et al.  Sick-building syndrome , 1997, The Lancet.

[10]  B. Brunekreef,et al.  Damp housing and adult respiratory symptoms , 1992, Allergy.

[11]  Range,et al.  Prevalence and determinants of house dust mite allergen in East German homes , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[12]  K Reijula,et al.  Bacteria, molds, and toxins in water-damaged building materials , 1997, Applied and environmental microbiology.

[13]  R. Rylander,et al.  Indoor air-related effects and airborne (1 --> 3)-beta-D-glucan. , 1999, Environmental health perspectives.

[14]  D. Norbäck,et al.  Volatile organic compounds, respirable dust, and personal factors related to prevalence and incidence of sick building syndrome in primary schools. , 1990, British journal of industrial medicine.

[15]  T. Meklin,et al.  The relationship between moisture or mould observations in houses and the state of health of their occupants. , 1999, The European respiratory journal.

[16]  Minoru Fujii,et al.  Field Validation of an Active Sampling Cartridge as a Passive Sampler for Long-Term Carbonyl Monitoring , 2004, Journal of the Air & Waste Management Association.

[17]  Y. Yanagisawa,et al.  Identification of responsible volatile chemicals that induce hypersensitive reactions to multiple chemical sensitivity patients , 2004, Journal of Exposure Analysis and Environmental Epidemiology.

[18]  A. K. Munir,et al.  Mite sensitization in the Scandinavian countries and factors influencing exposure , 1998, Allergy.

[19]  J Sundell,et al.  The Sick Building Syndrome (SBS) in office workers. A case-referent study of personal, psychosocial and building-related risk indicators. , 1994, International journal of epidemiology.

[20]  J. Myers,et al.  Influences on sick building syndrome symptoms in three buildings. , 1995, Social science & medicine.

[21]  P Wolkoff,et al.  Volatile organic compounds and indoor air. , 1994, The Journal of allergy and clinical immunology.

[22]  T. Hayashi [A study on the causes of an epidemic of influenza, especially an analysis of relative humidity as a main cause]. , 1985, Nihon Ika Daigaku zasshi.

[23]  T Schneider,et al.  'EUROPART'. Airborne particles in the indoor environment. A European interdisciplinary review of scientific evidence on associations between exposure to particles in buildings and health effects. , 2003, Indoor air.

[24]  O. Herbarth,et al.  Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study. , 2001, International journal of hygiene and environmental health.

[25]  J. Salvaggio Psychological aspects of "environmental illness," "multiple chemical sensitivity," and building-related illness. , 1994, The Journal of allergy and clinical immunology.

[26]  M J Hodgson,et al.  Symptoms and microenvironmental measures in nonproblem buildings. , 1991, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[27]  M. Garrett,et al.  Indoor environmental factors associated with house‐dust‐mite allergen (Der p i) levels in south‐eastern Australian houses , 1998, Allergy.

[28]  B. Doebbeling,et al.  Quality of life and health-services utilization in a population-based sample of military personnel reporting multiple chemical sensitivities. , 1999, Journal of occupational and environmental medicine.

[29]  J. Bourbeau,et al.  Building-related illnesses. , 1997, The New England journal of medicine.

[30]  R. Tamblyn,et al.  Exposure to varying levels of contaminants and symptoms among workers in two office buildings. , 1996, American journal of public health.

[31]  D Norbäck,et al.  Indoor air quality and personal factors related to the sick building syndrome. , 1990, Scandinavian journal of work, environment & health.

[32]  M. Hodgson Sick building syndrome. , 2000, Occupational medicine.

[33]  D Norbäck,et al.  Asthmatic symptoms and volatile organic compounds, formaldehyde, and carbon dioxide in dwellings. , 1995, Occupational and environmental medicine.

[34]  A Nevalainen,et al.  Comparison of two-level and three-level classifications of moisture-damaged dwellings in relation to health effects. , 2001, Indoor air.

[35]  S M Hunt,et al.  Damp housing, mould growth, and symptomatic health state. , 1989, BMJ.

[36]  M Krzyzanowski,et al.  The right to healthy indoor air: status by 2002. , 2003, Indoor air.

[37]  J Sakaguchi,et al.  Field survey of indoor air quality in detached houses in Niigata Prefecture. , 2003, Indoor air.

[38]  D Norbäck,et al.  Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitals , 1999, International archives of occupational and environmental health.

[39]  D Norbäck,et al.  Asthma symptoms in relation to building dampness and odour in older multifamily houses in Stockholm. , 2001, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[40]  B. Brunekreef,et al.  Respiratory symptoms in damp homes , 1989, Allergy.

[41]  Risto Kostiainen,et al.  Volatile organic compounds in the indoor air of normal and sick houses , 1995 .

[42]  J. Sabini,et al.  Sex differences in task performance associated with attention to ambient odor. , 1997, Archives of environmental health.