Hypersensitivity to pituitary snuff with miliary shadowing in the lungs.

Since 1924 powdered extracts of pig and ox pituitary glands have been used as nasal insufflations for the treatment of diabetes insipidus of mild to moderate severity, thereby avoiding the necessity for injections of pitressin tannate (Blumgart, 1922; Choay and Choay, 1924, 1928; Vidgoff, 1932; Smith, 1934). Choay and Choay (1946) and Marson (1955) have mentioned rhinorrhoea as the only side-effect of the powdered extracts. We wish to report a more serious complication in three patients who developed generalized miliary shadowing in the lung fields associated with bronchospasm and eosinophilia.

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