The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
暂无分享,去创建一个
J. Tamburini | S. Guichard | P. Auberger | A. Fricot | N. Ifrah | C. Lacombe | P. Mayeux | I. Moura | D. Bonnet | O. Hermine | D. Bouscary | Sophie Park | C. Vignon | F. Dreyfus | A. Puissant | O. Hérault | C. Lacombe | T. Maciel | N. Chapuis | S. Park | A. Green | L. Willems | N. Jacque
[1] I. Modlin,et al. Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor–mediated PI3K feedback loop activation via ERK1/2 and AKT , 2011, Cancer.
[2] Sarat Chandarlapaty,et al. mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. , 2011, Cancer discovery.
[3] A. Redig,et al. Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors , 2011, Clinical Cancer Research.
[4] P. Fisher,et al. Astrocyte elevated gene-1 induces protective autophagy , 2010, Proceedings of the National Academy of Sciences.
[5] B. Viollet,et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. , 2010, Blood.
[6] J. Tamburini,et al. Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia , 2010, Clinical Cancer Research.
[7] G. Robert,et al. Targeting autophagy to fight hematopoietic malignancies , 2010, Cell cycle.
[8] Walter Kolch,et al. Functional proteomics to dissect tyrosine kinase signalling pathways in cancer , 2010, Nature Reviews Cancer.
[9] J. Tamburini,et al. Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies , 2010, Leukemia.
[10] C. Chresta,et al. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells , 2010, Autophagy.
[11] S. Formenti,et al. Translational control in cancer , 2010, Nature Reviews Cancer.
[12] Jing Chen,et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor , 2010, Nature Medicine.
[13] Lisa L. Smith,et al. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. , 2010, Cancer research.
[14] D. Fingar,et al. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action* , 2009, The Journal of Biological Chemistry.
[15] J. Tamburini,et al. Targeting translation in acute myeloid leukemia: A new paradigm for therapy? , 2009, Cell cycle.
[16] M. Carroll,et al. A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia , 2009, Clinical Cancer Research.
[17] M. Carroll. Taking aim at protein translation in AML. , 2009, Blood.
[18] J. Tamburini,et al. Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. , 2009, Blood.
[19] Kevin Curran,et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. , 2009, Cancer research.
[20] B. Leber,et al. Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. , 2009, Blood.
[21] M. Dyer,et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. , 2009, The Journal of clinical investigation.
[22] C. Chresta,et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) , 2009, The Biochemical journal.
[23] D. Sabatini,et al. An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1* , 2009, Journal of Biological Chemistry.
[24] Gerard Manning,et al. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. , 2009, Cancer research.
[25] Robbie Loewith,et al. Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 , 2009, PLoS biology.
[26] D. Alessi,et al. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). , 2008, The Biochemical journal.
[27] P. Pandolfi,et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. , 2008, The Journal of clinical investigation.
[28] K. Shokat,et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML , 2008, Leukemia.
[29] J. Tamburini,et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. , 2008, Blood.
[30] X. Bai,et al. Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38 , 2007, Science.
[31] David M Sabatini,et al. Defining the role of mTOR in cancer. , 2007, Cancer cell.
[32] D. Sabatini,et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. , 2007, Blood.
[33] D. Sabatini. mTOR and cancer: insights into a complex relationship , 2006, Nature Reviews Cancer.
[34] Ji Luo,et al. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism , 2006, Nature Reviews Genetics.
[35] O. Meyuhas,et al. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. , 2006, Trends in biochemical sciences.
[36] C. E. Pearson,et al. Repeat instability: mechanisms of dynamic mutations , 2005, Nature Reviews Genetics.
[37] E. Solary,et al. Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia , 2005 .
[38] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[39] E. Solary,et al. Essential role for the p 110 δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia , 2005 .
[40] B. Manning. Balancing Akt with S6K , 2004, The Journal of cell biology.
[41] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[42] D. Guertin,et al. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.
[43] J. Graff,et al. eIF-4E expression and its role in malignancies and metastases , 2004, Oncogene.
[44] A. Kimchi,et al. Autophagy as a cell death and tumor suppressor mechanism , 2004, Oncogene.
[45] J. Arthur,et al. In vivo role of the PIF‐binding docking site of PDK1 defined by knock‐in mutation , 2003, The EMBO journal.
[46] A. Gingras,et al. Regulation of translation initiation by FRAP/mTOR. , 2001, Genes & development.
[47] T. Taniguchi,et al. A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. , 1991, Journal of immunology.