Spin-lattice relaxation times of bound water--its determination and implications for tissue discrimination.

Measurements were made of T1 of bound water (T1b) and bound water fraction (alpha) for gelatin solutions and human tissues (sera, brain tumor, cerebral white matter). Bound water fraction in each sample was measured by means of thermal analysis (differential scanning calorimetry: DSC). T1 values were measured by FONAR QED 80-alpha. T1b values were calculated by an equation derived from the fast-exchange two-state model. In the study of gelatin solutions, the relationship between T1 and water content differed depending on the sort of solutions. This was considered to be due to differences in T1b values. In each biological tissue the values of T1b and alpha had different distributions. These results indicate that values of T1b and alpha for biological tissues may be altered in correspondence to the changes in pathophysiological states in those tissues.

[1]  R. Chesnut,et al.  Water in normal muscle and muscle with a tumor. , 1975, Biochimica et biophysica acta.

[2]  J. Escanye,et al.  Frequency dependence of water proton longitudinal NMR relaxation times in mouse tissues around the freezing transition. , 1983, Biochimica et biophysica acta.

[3]  M. Pintar,et al.  A possible improvement in the resolution of proton spin relaxation for the study of cancer at low frequency. , 1975, Journal of the National Cancer Institute.

[4]  M Goldsmith,et al.  NUCLEAR MAGNETIC RESONANCE AS A NEW TOOL IN CANCER RESEARCH: HUMAN TUMORS BY NMR , 1973, Annals of the New York Academy of Sciences.

[5]  G D Fullerton,et al.  Frequency dependence of magnetic resonance spin-lattice relaxation of protons in biological materials. , 1984, Radiology.

[6]  J L Potter,et al.  NMR relaxation of protons in tissues and other macromolecular water solutions. , 1982, Magnetic resonance imaging.

[7]  W. Inch,et al.  Spin-lattice relaxation times for mixtures of water and gelatin or cotton, compared with normal and malignant tissue. , 1974, Journal of the National Cancer Institute.

[8]  T. Foster,et al.  A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.

[9]  R. Knispel,et al.  Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans. , 1974, Journal of the National Cancer Institute.

[10]  W. Brittin,et al.  Nuclear Magnetic Resonance Studies in Multiple Phase Systems: Lifetime of a Water Molecule in an Adsorbing Phase on Silica Gel , 1957 .

[11]  B. Fung.  Correlation of relaxation time with water content in muscle and brain tissues. , 1977, Biochimica et biophysica acta.

[12]  J. Escanye,et al.  Nuclear magnetic relaxation studies of water in frozen biological tissues. Cross-relaxation effects between protein and bound water protons , 1984 .

[13]  R. Damadian.  Tumor Detection by Nuclear Magnetic Resonance , 1971, Science.

[14]  C. Hazlewood,et al.  Nuclear magnetic resonance patterns of intracellular water as a function of HeLa cell cycle. , 1976, Science.

[15]  H. T. Edzes,et al.  Water in brain edema. Observations by the pulsed nuclear magnetic resonance technique. , 1975, Archives of neurology.

[16]  C. Tanaka,et al.  Proton nuclear magnetic resonance studies on brain edema. , 1982, Journal of neurosurgery.

[17]  S. Inao,et al.  Thermal Analysis on the State of Free and Bound Water in Normal and Edematous Brains , 1984 .

[18]  K. J. Packer,et al.  Pulsed NMR studies of water in striated muscle. 3. The effects of water content. , 1974, Biochimica et biophysica acta.

[19]  S. Inao,et al.  Dynamics of Tissue Water Content, Free and Bound Components, Associated with Ischemic Brain Edema , 1985 .

[20]  I D Kuntz,et al.  Hydration of Macromolecules , 1969, Science.

[21]  D. Medina,et al.  Relationship between hydration and proton nuclear magnetic resonance relaxation times in tissues of tumor-bearing and non-tumor-bearing mice: implications for cancer detection. , 1974, Journal of the National Cancer Institute.