Mycoplasma pneumoniae disease: clinical spectrum, pathophysiology, epidemiology, and control.

Mycoplasmas, formerly called pleuropneumonialike organisms, have been known for many years to be important causes of veterinary diseases, but Mycoplasma pneumoniae is the only member of this group of agents with proven pathogenicity for man. Mycoplasma pneumoniae was first isolated in the early 1940s by Eaton and his coworkers from a case of primary atypical pneumonia [1]; it was considered to be a virus until the early 1960s, when Marmion and Goodburn suggested that it was a pleuropneumonia-like organism [2]. Shortly after this, Chanock and his associates were able to grow the organism on artificial medium, providing further proof of its nature [3]. Finally, it was shown that it would infect man with resulting pneumonia; this proved that M. pneumoniae was a cause of human disease [4].

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