Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population

This study analyzed the correlations between the acute and habitual intake of dietary tyrosols, their main food sources, and 24 h urine excretions of tyrosol (Tyr) and hydroxytyrosol (OHTyr) in participants from the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (n = 419) were healthy men and women aged from 34 to 73 years from 8 EPIC centers belonging to France, Italy, and Germany. Acute and habitual dietary data were collected using a standardized 24 h dietary recall software and validated country-specific dietary questionnaires, respectively. The intake of 13 dietary tyrosols was estimated using the Phenol-Explorer database. Excretions of Tyr and OHTyr in a single 24 h urine sample were analyzed using tandem mass spectrometry. Urinary excretions of Tyr, OHTyr, and their sum (Tyr + OHTyr) correlated more strongly with their corresponding acute (rhopartial~0.63) rather than habitual intakes (rhopartial~0.47). In addition, individual and combined urinary excretions of Tyr and OHTyr were weakly to moderately correlated with the acute and habitual intake of other individual tyrosol precursors (rhopartial = 0.10–0.44) and especially with major food sources, such as wine (rhopartial = 0.41–0.58), olive oil (rhopartial = 0.25–0.44), and beer (rhopartial = 0.14–0.23). Urinary Tyr + OHTyr excretions were similarly correlated with the acute intake of total tyrosols but differently correlated with food sources among countries. Based on these results, we conclude that 24 h urinary excretions of Tyr + OHTyr could be proposed as biomarkers of total tyrosol intake, preferably for acute intakes.

[1]  M. C. García-Parrilla,et al.  Hydroxytyrosol in Foods: Analysis, Food Sources, EU Dietary Intake, and Potential Uses , 2022, Foods.

[2]  F. Priego-Capote,et al.  The secoiridoid profile of virgin olive oil conditions phenolic metabolism. , 2022, Food chemistry.

[3]  A. Åkesson,et al.  The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium , 2022, European Journal of Nutrition.

[4]  M. Schulze,et al.  Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study , 2021, Nutrients.

[5]  A. Cappiello,et al.  Tyrosol and Hydroxytyrosol Determination in Extra Virgin Olive Oil with Direct Liquid Electron Ionization-Tandem Mass Spectrometry , 2021, Separations.

[6]  M. L. Clodoveo,et al.  Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology. , 2021, Journal of pharmaceutical and biomedical analysis.

[7]  R. Gibson,et al.  Dietary Assessment Methods to Estimate (Poly)phenol Intake in Epidemiological Studies: A Systematic Review , 2021, Advances in nutrition.

[8]  J. Planas,et al.  Simultaneous determination of phenolic compounds in plasma by LC-ESI-MS/MS and their bioavailability after the ingestion of table olives. , 2020, Journal of agricultural and food chemistry.

[9]  Á. Gil-Izquierdo,et al.  Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans , 2020, European Journal of Nutrition.

[10]  R. de la Torre,et al.  Beer Phenolic Composition of Simple Phenols, Prenylated Flavonoids and Alkylresorcinols , 2020, Molecules.

[11]  J. Planas,et al.  Table olive polyphenols: A simultaneous determination by liquid chromatography-mass spectrometry. , 2020, Journal of chromatography. A.

[12]  R. Tyndale,et al.  Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans , 2019, Data in brief.

[13]  R. de la Torre,et al.  Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial , 2019, Nutrients.

[14]  Cvijeta Jakobušić Brala,et al.  Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health , 2019, Molecules.

[15]  G. Serreli,et al.  Biological Relevance of Extra Virgin Olive Oil Polyphenols Metabolites , 2018, Antioxidants.

[16]  R. de la Torre,et al.  Wine and Olive Oil Phenolic Compounds Interaction in Humans , 2018, Diseases.

[17]  E. Weiderpass,et al.  A new food-composition database for 437 polyphenols in 19,899 raw and prepared foods used to estimate polyphenol intakes in adults from 10 European countries. , 2018, The American journal of clinical nutrition.

[18]  F. Ricceri,et al.  Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study , 2016, Scientific Reports.

[19]  E. Riboli,et al.  Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study , 2016, European Journal of Nutrition.

[20]  A. Pastor,et al.  Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol , 2016, Drug metabolism reviews.

[21]  A. Scalbert,et al.  Differential Isotope Labeling of 38 Dietary Polyphenols and Their Quantification in Urine by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. , 2016, Analytical chemistry.

[22]  P. Robledo,et al.  Moderate consumption of wine, through both its phenolic compounds and alcohol content, promotes hydroxytyrosol endogenous generation in humans. A randomized controlled trial. , 2015, Molecular nutrition & food research.

[23]  I. Romieu,et al.  Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits , 2014, The American journal of clinical nutrition.

[24]  G. Beltrán,et al.  Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells , 2011, Nutrients.

[25]  Lee Hooper,et al.  Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review. , 2010, The American journal of clinical nutrition.

[26]  N Slimani,et al.  The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study , 2007, European Journal of Clinical Nutrition.

[27]  A. Segura‐Carretero,et al.  Evaluation of the antioxidant capacity of individual phenolic compounds in virgin olive oil. , 2005, Journal of agricultural and food chemistry.

[28]  N E Day,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection , 2002, Public Health Nutrition.

[29]  F. Clavel-Chapelon,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics , 2002, Public Health Nutrition.

[30]  E. Riboli,et al.  Standardization of the 24-hour diet recall calibration method used in the European Prospective Investigation into Cancer and Nutrition (EPIC): general concepts and preliminary results , 2000, European Journal of Clinical Nutrition.

[31]  E. Combet,et al.  High Resolution Mass Spectrometric Analysis of Secoiridoids and Metabolites as Biomarkers of Acute Olive Oil Intake—An Approach to Study Interindividual Variability in Humans , 2018, Molecular nutrition & food research.

[32]  E Riboli,et al.  The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. , 1997, International journal of epidemiology.

[33]  M. Ocké.  European prospective investigation into cancer and nutrition. Voedingsnavraag in de EPIC studie. , 1996 .