Polymeric scaffolds in tissue engineering: a literature review.

The tissue engineering scaffold acts as an extracellular matrix that interacts to the cells prior to forming new tissues. The chemical and structural characteristics of scaffolds are major concerns in fabricating of ideal three-dimensional structure for tissue engineering applications. The polymer scaffolds used for tissue engineering should possess proper architecture and mechanical properties in addition to supporting cell adhesion, proliferation, and differentiation. Much research has been done on the topic of polymeric scaffold properties such as surface topographic features (roughness and hydrophilicity) and scaffold microstructures (pore size, porosity, pore interconnectivity, and pore and fiber architectures) that influence the cell-scaffold interactions. In this review, efforts were given to evaluate the effect of both chemical and structural characteristics of scaffolds on cell behaviors such as adhesion, proliferation, migration, and differentiation. This review would provide the fundamental information which would be beneficial for scaffold design in future. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 431-459, 2017.

[1]  L. Gibson,et al.  The effect of pore size on cell adhesion in collagen-GAG scaffolds. , 2005, Biomaterials.

[2]  Hyeongjin Lee,et al.  A surface-modified poly(ɛ-caprolactone) scaffold comprising variable nanosized surface-roughness using a plasma treatment. , 2014, Tissue engineering. Part C, Methods.

[3]  Thomas J Webster,et al.  Endothelial and vascular smooth muscle cell function on poly(lactic-co-glycolic acid) with nano-structured surface features. , 2004, Biomaterials.

[4]  J. Lai,et al.  Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering , 2012, International journal of nanomedicine.

[5]  J. Goddard,et al.  Polymer surface modification for the attachment of bioactive compounds , 2007 .

[6]  A. Khojasteh,et al.  Current trends in mesenchymal stem cell application in bone augmentation: a review of the literature. , 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[7]  Fergal J O'Brien,et al.  The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering. , 2010, Biomaterials.

[8]  F. Demarco,et al.  Influence of poly-L-lactic acid scaffold's pore size on the proliferation and differentiation of dental pulp stem cells. , 2015, Brazilian dental journal.

[9]  Cato T Laurencin,et al.  Functionalization of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds via surface heparinization for bone tissue engineering. , 2009, Journal of biomedical materials research. Part A.

[10]  Richard A Black,et al.  Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds. , 2007, Biomaterials.

[11]  Clemens A van Blitterswijk,et al.  Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing. , 2010, Acta biomaterialia.

[12]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[13]  J. Ong,et al.  Efficacy of glow discharge gas plasma treatment as a surface modification process for three-dimensional poly (D,L-lactide) scaffolds. , 2003, Journal of biomedical materials research. Part A.

[14]  L. Bačáková,et al.  Resorbable polymeric scaffolds for bone tissue engineering: the influence of their microstructure on the growth of human osteoblast-like MG 63 cells. , 2009, Journal of biomedical materials research. Part A.

[15]  J. Stendahl,et al.  Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules. , 2004, Biomaterials.

[16]  B. Ratner,et al.  Effect of electrospun poly(D,L-lactide) fibrous scaffold with nanoporous surface on attachment of porcine esophageal epithelial cells and protein adsorption. , 2009, Journal of biomedical materials research. Part A.

[17]  Hsin-I Chang,et al.  Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds , 2011 .

[18]  Saeed Reza Motamedian,et al.  Smart scaffolds in bone tissue engineering: A systematic review of literature. , 2015, World journal of stem cells.

[19]  K. Shakesheff,et al.  The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds. , 2006, Biomaterials.

[20]  Yan Zhang,et al.  Galactosylated poly(ε-caprolactone) membrane promoted liver-specific functions of HepG2 cells in vitro. , 2014, Materials science & engineering. C, Materials for biological applications.

[21]  Hongfei Ji,et al.  Low intensity pulse ultrasound stimulate chondrocytes growth in a 3-D alginate scaffold through improved porosity and permeability. , 2015, Ultrasonics.

[22]  R. Reis,et al.  Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: an in vitro study. , 2010, Acta biomaterialia.

[23]  Peter X Ma,et al.  Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. , 2007, Biomaterials.

[24]  Paul H Wooley,et al.  Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[25]  Casey K. Chan,et al.  Enhancement of neurite outgrowth using nano-structured scaffolds coupled with laminin. , 2008, Biomaterials.

[26]  H. Fong,et al.  Tissue engineering of annulus fibrosus using electrospun fibrous scaffolds with aligned polycaprolactone fibers. , 2011, Journal of biomedical materials research. Part A.

[27]  Yong Wang,et al.  Adhesion and proliferation of OCT-1 osteoblast-like cells on micro- and nano-scale topography structured poly(L-lactide). , 2005, Biomaterials.

[28]  Andreas Greiner,et al.  Electrospinning approaches toward scaffold engineering--a brief overview. , 2006, Artificial organs.

[29]  A. Goldstein,et al.  Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. , 2006, Biomaterials.

[30]  A. Khojasteh,et al.  Effects of different growth factors and carriers on bone regeneration: a systematic review. , 2013, Oral surgery, oral medicine, oral pathology and oral radiology.

[31]  T. Webster,et al.  Decreased fibroblast and increased osteoblast adhesion on nanostructured NaOH-etched PLGA scaffolds , 2007, International journal of nanomedicine.

[32]  Christopher J Murphy,et al.  Modulation of human vascular endothelial cell behaviors by nanotopographic cues. , 2010, Biomaterials.

[33]  E. Biazar,et al.  Chitosan–Cross-Linked Nanofibrous PHBV Nerve Guide for Rat Sciatic Nerve Regeneration Across a Defect Bridge , 2013, ASAIO journal.

[34]  L. Bačáková,et al.  The influence of pore size on colonization of poly(l-lactide-glycolide) scaffolds with human osteoblast-like MG 63 cells in vitro , 2008, Journal of materials science. Materials in medicine.

[35]  S. Teoh,et al.  Surface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns. , 2009, Journal of biomedical materials research. Part A.

[36]  Ta-Jen Huang,et al.  Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. , 2009, Acta biomaterialia.

[37]  Thomas J Webster,et al.  Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications. , 2005, Biomaterials.

[38]  Girish Kumar,et al.  Freeform fabricated scaffolds with roughened struts that enhance both stem cell proliferation and differentiation by controlling cell shape. , 2012, Biomaterials.

[39]  A. Kocabas,et al.  Chemical and topographical modification of PHBV surface to promote osteoblast alignment and confinement. , 2008, Journal of biomedical materials research. Part A.

[40]  E. S. Bayrak,et al.  Pore Interconnectivity Influences Growth Factor-Mediated Vascularization in Sphere-Templated Hydrogels. , 2015, Tissue engineering. Part C, Methods.

[41]  Younan Xia,et al.  Three-dimensional scaffolds for tissue engineering: the importance of uniformity in pore size and structure. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[42]  Douglas A Lauffenburger,et al.  Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. , 2008, Biophysical journal.

[43]  Scott J Hollister,et al.  Three-dimensional poly(1,8-octanediol-co-citrate) scaffold pore shape and permeability effects on sub-cutaneous in vivo chondrogenesis using primary chondrocytes. , 2011, Acta biomaterialia.

[44]  J. Fisher,et al.  Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds. , 2011, Acta biomaterialia.

[45]  S. Teoh,et al.  Biocompatibility studies and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/polycaprolactone blends. , 2013, Journal of biomedical materials research. Part B, Applied biomaterials.

[46]  A. U. Daniels,et al.  Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition. , 2005, Biomaterials.

[47]  G. Bowlin,et al.  Low-temperature electrospun silk scaffold for in vitro mucosal modeling. , 2012, Journal of biomedical materials research. Part A.

[48]  D. Williams,et al.  Surface properties and biocompatibility of solvent-cast poly[-caprolactone] films. , 2004, Biomaterials.

[49]  Peter X Ma,et al.  Biomimetic materials for tissue engineering. , 2008, Advanced drug delivery reviews.

[50]  L. Germain,et al.  Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis. , 2011, Acta biomaterialia.

[51]  Scott J Hollister,et al.  Effect of polycaprolactone scaffold permeability on bone regeneration in vivo. , 2011, Tissue engineering. Part A.

[52]  V. Hasırcı,et al.  Bone tissue engineering on patterned collagen films: an in vitro study. , 2005, Biomaterials.

[53]  R. Tandon,et al.  Surface-modified electrospun poly(epsilon-caprolactone) scaffold with improved optical transparency and bioactivity for damaged ocular surface reconstruction. , 2014, Investigative ophthalmology & visual science.

[54]  Masoud Latifi,et al.  The influence of surface nanoroughness of electrospun PLGA nanofibrous scaffold on nerve cell adhesion and proliferation , 2013, Journal of Materials Science: Materials in Medicine.

[55]  Sang Ho Cho,et al.  Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. , 2003, Biomaterials.

[56]  Pieter Buma,et al.  Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes. , 2002, Biomaterials.

[57]  Jelena Rnjak-Kovacina,et al.  Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering. , 2011, Biomaterials.

[58]  K. Leong,et al.  The design of scaffolds for use in tissue engineering. Part I. Traditional factors. , 2001, Tissue engineering.

[59]  M. Soleimani,et al.  ADSCs on PLLA/PCL Hybrid Nanoscaffold and Gelatin Modification: Cytocompatibility and Mechanical Properties , 2015, Avicenna journal of medical biotechnology.

[60]  Young-Mi Kang,et al.  Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. , 2005, Biomaterials.

[61]  T. Webster,et al.  Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds. , 2005, Biomaterials.

[62]  Maria A. Woodruff,et al.  Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering , 2012 .

[63]  E. Biazar,et al.  Regeneration of Full-Thickness Skin Defects Using Umbilical Cord Blood Stem Cells Loaded into Modified Porous Scaffolds , 2014, ASAIO journal.

[64]  M. Hamid,et al.  Development and Characterization of Novel Porous 3D Alginate-Cockle Shell Powder Nanobiocomposite Bone Scaffold , 2014, BioMed research international.

[65]  C. V. van Blitterswijk,et al.  Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells. , 2012, Acta Biomaterialia.

[66]  S. Ramakrishna,et al.  Effects of plasma treatment to nanofibers on initial cell adhesion and cell morphology. , 2014, Colloids and surfaces. B, Biointerfaces.

[67]  Won Ho Park,et al.  Fabrication and characterization of 3-dimensional PLGA nanofiber/microfiber composite scaffolds , 2010 .

[68]  L G Griffith,et al.  Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. , 2001, Tissue engineering.

[69]  Scott J Hollister,et al.  The pore size of polycaprolactone scaffolds has limited influence on bone regeneration in an in vivo model. , 2010, Journal of biomedical materials research. Part A.

[70]  C. V. van Blitterswijk,et al.  The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. , 2005, Biomaterials.

[71]  Thomas J Webster,et al.  Nano-structured polymers enhance bladder smooth muscle cell function. , 2003, Biomaterials.

[72]  J. L. Santos,et al.  Bioinspired superhydrophobic poly(L-lactic acid) surfaces control bone marrow derived cells adhesion and proliferation. , 2009, Journal of biomedical materials research. Part A.

[73]  Xiangfang Peng,et al.  Properties and fibroblast cellular response of soft and hard thermoplastic polyurethane electrospun nanofibrous scaffolds. , 2015, Journal of biomedical materials research. Part B, Applied biomaterials.

[74]  Gregory C Rutledge,et al.  Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(epsilon-caprolactone) fibrous mats. , 2010, Biomaterials.

[75]  Lih-Sheng Turng,et al.  Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding. , 2013, Materials science & engineering. C, Materials for biological applications.

[76]  F. O'Brien,et al.  Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations. , 2009, Journal of biomedical materials research. Part A.

[77]  Valeria Chiono,et al.  An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering , 2014, International journal of molecular sciences.

[78]  Serena M. Best,et al.  Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films , 2012, Acta Biomaterialia.

[79]  Dong Li,et al.  Silk fibroin/collagen and silk fibroin/chitosan blended three-dimensional scaffolds for tissue engineering , 2015, European Journal of Orthopaedic Surgery & Traumatology.

[80]  S. Hsu,et al.  Synthesis and 3D Printing of Biodegradable Polyurethane Elastomer by a Water‐Based Process for Cartilage Tissue Engineering Applications , 2014, Advanced healthcare materials.

[81]  Mauro Grigioni,et al.  Structural characterization and cell response evaluation of electrospun PCL membranes: micrometric versus submicrometric fibers. , 2009, Journal of biomedical materials research. Part A.

[82]  E H Burger,et al.  Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations. , 1999, Journal of biomedical materials research.

[83]  Tze-Wen Chung,et al.  Enhancement of the growth of human endothelial cells by surface roughness at nanometer scale. , 2003, Biomaterials.

[84]  Jeong Eun Song,et al.  Effect of pore sizes of PLGA scaffolds on mechanical properties and cell behaviour for nucleus pulposus regeneration in vivo , 2017, Journal of tissue engineering and regenerative medicine.

[85]  V. Vogel,et al.  Influence of the fiber diameter and surface roughness of electrospun vascular grafts on blood activation. , 2012, Acta biomaterialia.

[86]  N. Kawazoe,et al.  Pore size effect of collagen scaffolds on cartilage regeneration. , 2014, Acta biomaterialia.

[87]  E. Entcheva,et al.  Electrospun fine-textured scaffolds for heart tissue constructs. , 2005, Biomaterials.

[88]  Hwa-Chang Liu,et al.  Preparation of PLLA membranes with different morphologies for culture of MG-63 Cells. , 2004, Biomaterials.

[89]  S. Chowdhury,et al.  Cytotoxic evaluation of biomechanically improved crosslinked ovine collagen on human dermal fibroblasts. , 2014, Bio-medical materials and engineering.

[90]  M. Soleimani,et al.  Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalcium phosphate/hydroxyapatite scaffold. , 2008, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[91]  Tabatabaei Qomi,et al.  The Design of Scaffolds for Use in Tissue Engineering , 2014 .

[92]  C. Vaquette,et al.  Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration. , 2011, Acta biomaterialia.

[93]  George J Christ,et al.  The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. , 2008, Biomaterials.

[94]  Jin Man Kim,et al.  In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. , 2007, Biomaterials.

[95]  M. Riehle,et al.  Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. , 2010, Acta biomaterialia.

[96]  P. Ma,et al.  The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells. , 2011, Biomaterials.

[97]  S. Hsu,et al.  Evaluation of biodegradable elastic scaffolds made of anionic polyurethane for cartilage tissue engineering. , 2015, Colloids and surfaces. B, Biointerfaces.