Oral cavity and oropharyngeal cancer incidence trends and disparities in the United States: 2000-2010.

BACKGROUND Changes in the incidence of oral cancer based on anatomic location and demographic factors over time have been reported in the United States. The purpose of this study was to use recent data to examine oral cancer incidence trends and disparities by demographic factors and anatomic location. METHODS Surveillance, Epidemiology, and End Results (SEER) incidence data from 2000 to 2010 were used to characterize and analyze oral cancer incidence trends by anatomic region and subsite, age at diagnosis, gender, race/ethnicity, and stage at diagnosis. Poisson regression was used to compare incidence risk by select demographic factors. RESULTS About 75,468 incident oral cancer cases were diagnosed from 2000 to 2010. The tonsil was the most frequently diagnosed anatomic subsite (23.1%) and the subsite with the greatest contribution to the overall, age-standardized cumulative incidence rate of 8.4 cases per 100,000 (95% confidence interval (CI): 8.3, 8.4). An increasing incidence trend was observed for cancers in the oropharyngeal region, in contrast to a decreasing trend seen in the oral cavity region. In the Poisson regression model, all race/ethnicity groups showed a lower incidence risk relative to whites for oral cavity and oropharyngeal cancer, and white males displayed the highest incidence rate of all race/ethnicity-gender groups during the study period (14.1 per 100,000; 95% CI: 14.0, 14.2). CONCLUSIONS This study's epidemiological findings are especially important for oral health care providers, patient education, and the identification of risk profiles associated with oral cancer. The distinct epidemiological trends of oral cavity and oropharyngeal cancers dictate that oral cancer can no longer be viewed as a discrete entity. Oral health providers should have a strong understanding of the different risk factors associated with oral cavity and oropharyngeal cancers and educate their patients accordingly.

[1]  Marcel Zeelenberg,et al.  Data analysis 2 , 2016 .

[2]  J. Fortenberry,et al.  Sexual behavior in the United States: results from a national probability sample of men and women ages 14-94. , 2010, The journal of sexual medicine.

[3]  D. Wilson,et al.  'Oral cancer'--the terminology dilemma. , 2008, Oral diseases.

[4]  W. Westra,et al.  Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus‐associated head and neck cancer based on a prospective clinical experience , 2010, Cancer.

[5]  M. Junger,et al.  The connection between human papillomavirus and oropharyngeal squamous cell carcinomas in the United States: implications for dentistry. , 2011, Journal of the American Dental Association.

[6]  L. Brown,et al.  Oral Cavity and Pharynx Cancer Incidence Trends by Subsite in the United States: Changing Gender Patterns , 2012, Journal of oncology.

[7]  A. Chandra,et al.  Prevalence and correlates of heterosexual anal and oral sex in adolescents and adults in the United States. , 2007, The Journal of infectious diseases.

[8]  R. Lambert,et al.  Epidemiology of cancer from the oral cavity and oropharynx , 2011, European journal of gastroenterology & hepatology.

[9]  A. Chaturvedi,et al.  Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  S. Warnakulasuriya.  Global epidemiology of oral and oropharyngeal cancer. , 2009, Oral oncology.

[11]  P. Sparén,et al.  Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma? , 2009, International journal of cancer.

[12]  D. Luce,et al.  A review of risk factors for oral cavity cancer: the importance of a standardized case definition. , 2013, Community dentistry and oral epidemiology.

[13]  J. Bowie,et al.  Differences in Oral Sexual Behaviors by Gender, Age, and Race Explain Observed Differences in Prevalence of Oral Human Papillomavirus Infection , 2014, PloS one.

[14]  Esther Kim,et al.  Human papillomavirus and rising oropharyngeal cancer incidence in the United States. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  L. Brown,et al.  Oropharyngeal cancer incidence trends: diminishing racial disparities , 2011, Cancer Causes & Control.

[16]  S. Coughlin,et al.  Burden of potentially human papillomavirus‐associated cancers of the oropharynx and oral cavity in the US, 1998–2003 , 2008, Cancer.

[17]  E. Munck‐Wikland,et al.  Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer , 2006, International journal of cancer.

[18]  T. Ramqvist,et al.  An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) infection and aspects of treatment and prevention. , 2011, Anticancer research.

[19]  Ram C Tiwari,et al.  Efficient interval estimation for age-adjusted cancer rates , 2006, Statistical methods in medical research.

[20]  A. Zini,et al.  Lip cancer: incidence, trends, histology and survival: 1970–2006 , 2010, The British journal of dermatology.

[21]  E. Sturgis,et al.  Trends in head and neck cancer incidence in relation to smoking prevalence , 2007, Cancer.

[22]  S. Franceschi,et al.  Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review , 2005, Cancer Epidemiology Biomarkers & Prevention.

[23]  L. Figgs,et al.  Differences in cancer incidence, mortality, and survival between African Americans and whites. , 1995, Environmental health perspectives.

[24]  Carole Fakhry,et al.  Case-control study of human papillomavirus and oropharyngeal cancer. , 2007, The New England journal of medicine.

[25]  Megan Scudellari,et al.  HPV: Sex, cancer and a virus , 2013, Nature.