EXPERT SYSTEMS FOR CANCER CHEMOTHERAPY

Abstract In the present paper we describe BREASTCAN and NEWCHEM, two expert systems for the characterization of optimal adjuvant cancer therapies. The purpose of BREASTCAN is to support physicians in the postoperative breast cancer therapy, on the basis of currently used therapy protocols. It was developed in Prolog and positively validated, referring to the chemotherapies used by oncologists for some patients in the National Cancer Institute in Milan. NEWCHEM is a system oriented to the development of new cancer therapies, based on pharmaco-cell kinetic modeling and the newest molecular knowledge about neoplastic process. The system is being built and at first it will be validated by experiments on mice. Our aim with NEWCHEM is to extend our knowledge base and our rules to incorporate also all the modt advanced knowledge at the molecular and cellular level, both theoretical and experimental, to make readily accessible to the health-community a system was the present state of the art allows.

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