Interleukin‐6 and transforming growth factor‐β synergistically stimulate chondrosarcoma cell proliferation

This study examines the regulation of Swarm rat chondrosarcoma (SRC) cell proliferation in vitro. In serum‐free cultures, SRC cells showed only transient DNA synthesis and this was increased by serum. Transforming growth factor‐β (TGF‐β) was identified as an essential serum component, since the mitogenic effect of sera was related to their TGF‐β content and neutralized by antibody to TGF‐β.

[1]  C. Dubois,et al.  Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action , 1990, The Journal of experimental medicine.

[2]  T. Hirano,et al.  AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[3]  P. Guerne,et al.  IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. , 1990, Journal of immunology.

[4]  M. Sporn,et al.  Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis. , 1990, The Journal of biological chemistry.

[5]  J. Massagué,et al.  Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta , 1989, The Journal of cell biology.

[6]  M. Noda,et al.  Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells , 1989, The Journal of cell biology.

[7]  P. Sehgal,et al.  Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells , 1989, The Journal of experimental medicine.

[8]  T. Hirano,et al.  Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 , 1989, Cell.

[9]  X. Ronot,et al.  Growth-promoting effects of acidic and basic fibroblast growth factor on rabbit articular chondrocytes aging in culture. , 1989, Experimental cell research.

[10]  D. P. Murphy,et al.  Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[11]  T. Kishimoto,et al.  The biology of interleukin-6. , 1989, Blood.

[12]  T. Podor,et al.  Human Endothelial Cells Produce IL‐6 , 1989 .

[13]  D. Bowen-Pope,et al.  Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-beta. , 1989, The Journal of biological chemistry.

[14]  K. Sato,et al.  Interleukin 1: a regulator of chondrocyte proliferation. , 1989, Immunology letters.

[15]  M. Binoux,et al.  Production of insulin-like growth factors and their binding proteins by rabbit articular chondrocytes: relationships with cell multiplication. , 1989, Endocrinology.

[16]  Thomas A. Mustoe, MD, FACS,et al.  Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[17]  K. Sato,et al.  Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-beta. , 1989, Biochemical and biophysical research communications.

[18]  C. Heldin,et al.  Role for carbohydrate structures inTGF-β1 latency , 1989, Nature.

[19]  M. Sporn,et al.  Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice , 1989, The Journal of cell biology.

[20]  H. Mankin,et al.  Growth factor stimulation of adult articular cartilage , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[21]  M. Sporn,et al.  Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming growth factor beta 4 from chicken embryo chondrocytes. , 1988, Molecular endocrinology.

[22]  K. Flanders,et al.  Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development , 1988, The Journal of cell biology.

[23]  K. Kuettner,et al.  A long term culture of cells from Swarm rat chondrosarcoma in suspension after alginate preculture. , 1988, The Keio journal of medicine.

[24]  E. Canalis,et al.  Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[25]  P. ten Dijke,et al.  Identification of another member of the transforming growth factor type beta gene family. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Moses,et al.  Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium , 1988, The Journal of cell biology.

[27]  R. Hirai,et al.  Effect of transforming growth factor beta on cell proliferation and glycosaminoglycan synthesis by rabbit growth-plate chondrocytes in culture. , 1988, Biochimica et biophysica acta.

[28]  M. Hirata,et al.  Effects of human recombinant tumor necrosis factor-alpha and interleukin 1 on the synthesis of glycosaminoglycan and DNA in cultured rat costal chondrocytes. , 1988, Journal of immunology.

[29]  O. Söder,et al.  Stimulation of chondrocyte DNA synthesis by interleukin-1. , 1988, British journal of rheumatology.

[30]  E. Canalis,et al.  Growth factors and the regulation of bone remodeling. , 1988, The Journal of clinical investigation.

[31]  M. O’Connor-McCourt,et al.  Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin. , 1987, The Journal of biological chemistry.

[32]  J. Graycar,et al.  Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta. , 1987, The Journal of biological chemistry.

[33]  D. Rosen,et al.  Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells. , 1986, The Journal of biological chemistry.

[34]  A. Dahlström,et al.  Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plate. , 1986, Science.

[35]  J. McPherson,et al.  Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta. , 1986, The Journal of biological chemistry.

[36]  M. Sporn,et al.  Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. , 1984, The Journal of biological chemistry.

[37]  M. Sporn,et al.  Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts , 1984, Cell.

[38]  D. Gardner.  Fine Structure of Synovial Joints , 1984 .

[39]  L. Sokoloff,et al.  Effect of purified growth factors on rabbit articular chondrocytes in monolayer culture. I. Dna synthesis. , 1982, Arthritis and rheumatism.

[40]  H. Lebovitz,et al.  Hormone responsiveness of a transplantable rat chondrosarcoma: III. ultrastructural evidence of in vivo hormone dependence. , 1981, The American journal of pathology.

[41]  V. Hascall,et al.  Effects of insulin and multiplication-stimulating activity on proteoglycan biosynthesis in chondrocytes from the Swarm rat chondrosarcoma. , 1981, The Journal of biological chemistry.

[42]  H. Lebovitz,et al.  Hormone responsiveness of a transplantable rat chondrosarcoma. II. Evidence for in vivo hormone dependence. , 1980, Endocrinology.

[43]  H. Lebovitz,et al.  Hormone responsiveness of a transplantable rat chondrosarcoma. I. In vitro effects of growth hormone-dependent serum factors and insulin. , 1980, Endocrinology.

[44]  D. Salomon,et al.  Hormone-dependent growth of a rat chondrosarcoma in vivo. , 1979, Cancer research.

[45]  K. Meyer,et al.  Mucopolysaccharide and protein--polysaccharide of a transplantable rat chondrosarcoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.