Toxicological Assessment of Flavors Used in E-vapor Products

[1]  P. Hung,et al.  In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS , 2020, Journal of applied toxicology : JAT.

[2]  M. Peitsch,et al.  E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model , 2020, Archives of Toxicology.

[3]  M. Peitsch,et al.  Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis , 2020, Archives of Toxicology.

[4]  Trevor M Penning,et al.  Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps , 2020, Chemical research in toxicology.

[5]  M. Peitsch,et al.  A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke. , 2020, American journal of physiology. Heart and circulatory physiology.

[6]  Rémi H. J. Dulize,et al.  Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells , 2019, Toxicology reports.

[7]  G. Jaccard,et al.  Selected harmful and potentially harmful constituents levels in commercial e-cigarettes. , 2019, Chemical research in toxicology.

[8]  I. Rahman,et al.  E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes , 2019, Scientific Reports.

[9]  P. Vanscheeuwijck,et al.  Lysosomotropic-related limitations of the BALB/c 3T3 cell-based neutral red uptake assay and an alternative testing approach for assessing e-liquid cytotoxicity. , 2019, Toxicology in vitro : an international journal published in association with BIBRA.

[10]  K. Kreiss,et al.  Flavorings-Related Lung Disease: A Brief Review and New Mechanistic Data , 2019, Toxicologic pathology.

[11]  M. Peitsch,et al.  Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology , 2019, Archives of Toxicology.

[12]  K. Nadeau,et al.  Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. , 2019, Journal of the American College of Cardiology.

[13]  T. Walele,et al.  The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e‐liquids , 2019, Regulatory toxicology and pharmacology : RTP.

[14]  M. Peitsch,et al.  A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment , 2019, Internal and Emergency Medicine.

[15]  P. Talbot,et al.  Identification of Cytotoxic Flavor Chemicals in Top-Selling Electronic Cigarette Refill Fluids , 2019, Scientific Reports.

[16]  J. Hoeng,et al.  New approaches to risk assessment of chemical mixtures , 2019, Toxicology Research and Application.

[17]  M. Peitsch,et al.  Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols , 2018, Inhalation toxicology.

[18]  P. Anastas,et al.  Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[19]  A. Penn,et al.  Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies. , 2018, Journal of visualized experiments : JoVE.

[20]  L. Brose,et al.  Evidence review of e-cigarettes and heated tobacco products 2018: a report commissioned by Public Health England. , 2018 .

[21]  G. Glish,et al.  Evaluation of e-liquid toxicity using an open-source high-throughput screening assay , 2018, PLoS biology.

[22]  I. Rahman,et al.  Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine , 2018, Front. Physiol..

[23]  M. Peitsch,et al.  Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  R. Bengalli,et al.  Lung Toxicity of Condensed Aerosol from E-CIG Liquids: Influence of the Flavor and the In Vitro Model Used , 2017, International journal of environmental research and public health.

[25]  D. Christiani,et al.  Flavoring Chemicals and Aldehydes in E-Cigarette Emissions. , 2017, Environmental science & technology.

[26]  C. Rose.  Early detection, clinical diagnosis, and management of lung disease from exposure to diacetyl. , 2017, Toxicology.

[27]  J. López-Belmonte,et al.  An approach to allergy risk assessments for e‐liquid ingredients , 2017, Regulatory toxicology and pharmacology : RTP.

[28]  K. Wallace.  Future perspective of butter flavorings-related occupational lung disease. , 2017, Toxicology.

[29]  E. Soule,et al.  Electronic cigarettes: what are they and what do they do? , 2017, Annals of the New York Academy of Sciences.

[30]  I. Rahman,et al.  Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography–Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts , 2017, Applied in vitro toxicology.

[31]  K. Farsalinos,et al.  Comment on "Flavoring Compounds Dominate Toxic Aldehyde Production during E Cigarette Vaping". , 2017, Environmental science & technology.

[32]  A. Khlystov,et al.  Flavoring Compounds Dominate Toxic Aldehyde Production during E-Cigarette Vaping. , 2016, Environmental science & technology.

[33]  N. Saliba,et al.  Detection of 5-hydroxymethylfurfural and furfural in the aerosol of electronic cigarettes , 2016, Tobacco Control.

[34]  P. Talbot,et al.  Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols , 2016, Tobacco Control.

[35]  M. Goniewicz,et al.  Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS) , 2016, Tobacco Control.

[36]  Eoon Hye Ji,et al.  Characterization of Electronic Cigarette Aerosol and Its Induction of Oxidative Stress Response in Oral Keratinocytes , 2016, PloS one.

[37]  S. Boitano,et al.  Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine , 2016, Respiratory Research.

[38]  O. Geiss,et al.  Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. , 2016, International journal of hygiene and environmental health.

[39]  Manuel C. Peitsch,et al.  A framework for in vitro systems toxicology assessment of e-liquids , 2016, Toxicology mechanisms and methods.

[40]  D. Morgan,et al.  Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents , 2016, Toxicologic pathology.

[41]  Harry Vrieling,et al.  The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[42]  P. Lilly,et al.  Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats , 2016, Inhalation toxicology.

[43]  Manuel C. Peitsch,et al.  An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[44]  M. Peitsch,et al.  Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology , 2015, Inhalation toxicology.

[45]  C. Meredith,et al.  An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids. , 2015, Regulatory toxicology and pharmacology : RTP.

[46]  Hongwei Yao,et al.  Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung , 2015, PloS one.

[47]  Yang Xiang,et al.  Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models , 2014, BMC Bioinformatics.

[48]  Anthony Gamst,et al.  Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation , 2014, Tobacco Control.

[49]  A. Luch,et al.  Chemical hazards present in liquids and vapors of electronic cigarettes , 2014, Archives of Toxicology.

[50]  Michael S Orr,et al.  Electronic cigarettes in the USA: a summary of available toxicology data and suggestions for the future , 2014, Tobacco Control.

[51]  J. Namieśnik,et al.  An evaluation of sucrose as a possible contaminant in e-liquids for electronic cigarettes by hydrophilic interaction liquid chromatography–tandem mass spectrometry , 2014, Analytical and Bioanalytical Chemistry.

[52]  R. Polosa,et al.  A fresh look at tobacco harm reduction: the case for the electronic cigarette , 2013, Harm Reduction Journal.

[53]  K. Farsalinos,et al.  Comparison of the Cytotoxic Potential of Cigarette Smoke and Electronic Cigarette Vapour Extract on Cultured Myocardial Cells , 2013, International journal of environmental research and public health.

[54]  Prue Talbot,et al.  Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. , 2012, Reproductive toxicology.

[55]  Julia Hoeng,et al.  A network-based approach to quantifying the impact of biologically active substances. , 2012, Drug discovery today.

[56]  Michael Balls,et al.  The Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment , 2012, Advances in experimental medicine and biology.

[57]  S. Gutsell,et al.  Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[58]  D. J. Alexander,et al.  Association of Inhalation Toxicologists (AIT) Working Party Recommendation for Standard Delivered Dose Calculation and Expression in Non-Clinical Aerosol Inhalation Toxicology Studies with Pharmaceuticals , 2008 .

[59]  P. Enright,et al.  Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. , 2002, The New England journal of medicine.

[60]  E Kennepohl,et al.  A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.