论文信息 - Irnigaine and N-Methylirnigaine, Two New Piperidinol Alkaloids from the Tubers of Arisarum vulgare

Irnigaine and N-Methylirnigaine, Two New Piperidinol Alkaloids from the Tubers of Arisarum vulgare

Abstract From the tubers of Arisarum vulgare, we have isolated two new toxic piperidinol alkaloids. By 2D COSY NMR spectroscopic methods, their structures were elucidated as follows Irnigaine 3: (-)-(2S,3S,6R)-3-hydroxy-2-methyl-6-(9′-phenylnonyl)piperidine and N-methylirnigaine 4: (-)-(2S,3S,6R)-1,2-dimethyl-3-hydroxy-6-(9′-phenylnonyl) piperidine.

B. Bodo | A. Melhaoui

[1] B. Bodo,et al. Antibiotic and Antifungal Pyrrolidine Alkaloids, from Arisarum vulgare , 1993 .

[2] B. Bodo,et al. Structure of irniine a pyrrolidine alkaloid from arisarum vulgare , 1992 .

[3] D. E. Nichols,et al. Brine shrimp: a convenient general bioassay for active plant constituents. , 1982, Planta medica.

[4] I. Christofidis,et al. Spectaline and iso-6 cassine, two new piperidin 3-ol alkaloids from the leaves of cassia spectabilis , 1977 .

[5] P. Casals,et al. Stereochimie des dialcoyl-2,6 piperidinols-3 , 1972 .

[6] C. K. Spicer,et al. Hydrogen Bonding and Conformational Analysis of 3-Piperidinol Derivatives , 1966 .

[7] J. Coke,et al. Structure and Configuration of Alkaloids. II. Cassine1,2 , 1966 .

[8] J. K. Williams,et al. Alkyl- and Aryltricyanomethanes. Synthesis and Properties , 1966 .