Hypothesis: sarcoidosis is a STAT1-mediated disease.

[1]  R. Freire,et al.  Interferon-induced sarcoidosis , 2011, BMJ Case Reports.

[2]  Justine R. Smith,et al.  Application of Biostatistics and Bioinformatics Tools to Identify Putative Transcription Factor-Gene Regulatory Network of Ankylosing Spondylitis and Sarcoidosis , 2009, Communications in statistics: theory and methods.

[3]  Sandya Liyanarachchi,et al.  Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. , 2009, American journal of respiratory and critical care medicine.

[4]  Justine R. Smith,et al.  Gene expression profiling of whole blood: Comparison of target preparation methods for accurate and reproducible microarray analysis , 2009, BMC Genomics.

[5]  T. Schiano,et al.  Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation , 2008, Transplant infectious disease : an official journal of the Transplantation Society.

[6]  H. Gendelman,et al.  STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. , 2008, Blood.

[7]  M. Martinka,et al.  Bim expression is reduced in human cutaneous melanomas. , 2008, The Journal of investigative dermatology.

[8]  A. Bosio,et al.  Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis. , 2008, The Journal of investigative dermatology.

[9]  Marcus Müller,et al.  Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN‐γ but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro , 2007, Glia.

[10]  B. Shepherd,et al.  Multiple Mycobacterium antigens induce interferon‐γ production from sarcoidosis peripheral blood mononuclear cells , 2007, Clinical and experimental immunology.

[11]  R. Lidereau,et al.  Gene arrays for diagnosis, prognosis and treatment of breast cancer metastasis , 2007, Clinical & Experimental Metastasis.

[12]  Wentian Li,et al.  STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. , 2007, The New England journal of medicine.

[13]  A. Bjartell,et al.  The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids , 2007, International Journal of Colorectal Disease.

[14]  N. Morar,et al.  The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis. , 2007, The American journal of pathology.

[15]  P. Scott,et al.  STAT1 Expression in Dendritic Cells, but Not T Cells, Is Required for Immunity to Leishmania major1 , 2007, The Journal of Immunology.

[16]  R. Baughman,et al.  Sarcoidosis, role of tumor necrosis factor inhibitors and other biologic agents, past, present, and future concepts. , 2007, Clinics in dermatology.

[17]  L. Newman,et al.  Gene-environment interactions in sarcoidosis: challenge and opportunity. , 2007, Clinics in dermatology.

[18]  A. Steere,et al.  High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. , 2007, Arthritis and rheumatism.

[19]  P. Gregersen,et al.  An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity , 2007, Molecular medicine.

[20]  C Cadwell,et al.  A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. , 2006, Rheumatology.

[21]  J. Jagirdar,et al.  Sarcoidosis after treatment with interferon-α: A case series and review of the literature , 2006 .

[22]  P. Tonali,et al.  pSTAT1, pSTAT3, and T‐bet expression in peripheral blood mononuclear cells from relapsing‐remitting multiple sclerosis patients correlates with disease activity , 2006, Journal of neuroscience research.

[23]  C. Mathieu,et al.  Immune Regulation of 25-Hydroxyvitamin D-1α-Hydroxylase in Human Monocytic THP1 Cells: Mechanisms of Interferon-γ-Mediated Induction , 2006 .

[24]  J. Casanova,et al.  Novel STAT1 Alleles in Otherwise Healthy Patients with Mycobacterial Disease , 2006, PLoS genetics.

[25]  S. Richardson,et al.  Progressive pulmonary sarcoidosis is associated with over-expression of TYK2 and p21Waf1/Cip1. , 2006, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.

[26]  N. Siafakas,et al.  Upregulation of Th1 cytokine profile (IL-12, IL-18) in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis. , 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[27]  T. Hattori,et al.  Elevated serum levels of CXCL9/monokine induced by interferon-γ and cxcl10/interferon-γ-inducible protein-10 in ocular sarcoidosis , 2006 .

[28]  T. Hattori,et al.  Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis. , 2006, Investigative ophthalmology & visual science.

[29]  J. Peters,et al.  Sarcoidosis after treatment with interferon-alpha: a case series and review of the literature. , 2006, Respiratory medicine.

[30]  E. Fish,et al.  Stats: multifaceted regulators of transcription. , 2005, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[31]  F. Askin,et al.  Mycobacterial catalase–peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis , 2005, The Journal of experimental medicine.

[32]  S. Lai,et al.  Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals. , 2004, Journal of helminthology.

[33]  A. Achiron,et al.  Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus , 2004, Clinical and experimental immunology.

[34]  M. Kaplan,et al.  Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism. , 2004, Endocrinology.

[35]  Rafael A. Irizarry,et al.  A Model-Based Background Adjustment for Oligonucleotide Expression Arrays , 2004 .

[36]  P. Tak,et al.  Activation of the STAT1 pathway in rheumatoid arthritis , 2004, Annals of the rheumatic diseases.

[37]  L. van der Fits,et al.  In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered. , 2004, The Journal of investigative dermatology.

[38]  L. Staudt,et al.  Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. , 2004, Blood.

[39]  H. Yamada,et al.  STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection. , 2004, The Tohoku journal of experimental medicine.

[40]  Richard Simon,et al.  A random variance model for detection of differential gene expression in small microarray experiments , 2003, Bioinform..

[41]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[42]  G. Karypis,et al.  Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  John D. Storey.  A direct approach to false discovery rates , 2002 .

[44]  P. Schimmel,et al.  A fragment of human TrpRS as a potent antagonist of ocular angiogenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[45]  C. Amos,et al.  Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. , 2001, Journal of the National Cancer Institute.

[46]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[47]  K. Chida,et al.  TH1/TH2 and TC1/TC2 profiles in peripheral blood and bronchoalveolar lavage fluid cells in pulmonary sarcoidosis. , 2001, The Journal of allergy and clinical immunology.

[48]  C. Li,et al.  Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[49]  W. Luttmann,et al.  Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4+ and CD8+ T cells , 2000, Clinical and experimental immunology.

[50]  J. Harton,et al.  Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression , 2000, Molecular and Cellular Biology.

[51]  Xin Chen,et al.  TRANSFAC: an integrated system for gene expression regulation , 2000, Nucleic Acids Res..

[52]  L. Bermudez,et al.  Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection , 1996, Infection and immunity.

[53]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[54]  S. Tonegawa,et al.  Altered peptidase and viral-specific T cell response in LMP2 mutant mice. , 1994, Immunity.

[55]  R. Pearse,et al.  Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[56]  T. Shows,et al.  Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors. , 1991, Oncogene.

[57]  T. Taniguchi,et al.  Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated , 1990, Cell.

[58]  F. Sigaux,et al.  The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[59]  P. Nowell,et al.  Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. , 1984, Science.

[60]  R. Winterbauer,et al.  Clinical interpretation of bilateral hilar adenopathy. , 1973, Annals of internal medicine.