Cysteine cathepsins and extracellular matrix degradation.

[1]  H. Genant,et al.  The Effect of the Cathepsin K Inhibitor ONO‐5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  R. Chapurlat.  Treatment of postmenopausal osteoporosis with odanacatib , 2014, Expert opinion on pharmacotherapy.

[3]  D. Brömme,et al.  The role of basic amino acid surface clusters on the collagenase activity of cathepsin K. , 2013, Biochemistry.

[4]  C. Craik,et al.  Elastin Degradation by Cathepsin V Requires Two Exosites* , 2013, The Journal of Biological Chemistry.

[5]  Donald S. Williams,et al.  Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate. , 2013, Bone.

[6]  T. Livache,et al.  Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity. , 2013, Biochemistry.

[7]  Marko Novinec,et al.  Cathepsin K: a unique collagenolytic cysteine peptidase , 2013, Biological chemistry.

[8]  J. Lindholt,et al.  Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. , 2013, Atherosclerosis.

[9]  R. Veldhuizen,et al.  Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties. , 2013, The international journal of biochemistry & cell biology.

[10]  C. Zerbini,et al.  Odanacatib in postmenopausal women with low bone mineral density: a review of current clinical evidence , 2013, Therapeutic advances in musculoskeletal disease.

[11]  D. Turk.  MAIN software for density averaging, model building, structure refinement and validation , 2013, Acta crystallographica. Section D, Biological crystallography.

[12]  L. V. Van Bortel,et al.  Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers. , 2013, British journal of clinical pharmacology.

[13]  K. Okumura,et al.  Circulating cathepsin K as a potential novel biomarker of coronary artery disease. , 2013, Atherosclerosis.

[14]  A. Dufour,et al.  Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. , 2013, Trends in pharmacological sciences.

[15]  G. Fields.  Interstitial Collagen Catabolism* , 2013, The Journal of Biological Chemistry.

[16]  Bonnie F. Sloane,et al.  The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes , 2013, Biological chemistry.

[17]  B. Dardzinski,et al.  Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: a randomized trial. , 2013, The Journal of clinical endocrinology and metabolism.

[18]  Hongbin Li,et al.  Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers* , 2013, The Journal of Biological Chemistry.

[19]  Chao-shu Tang,et al.  Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. , 2012, Cardiovascular research.

[20]  P. Saftig,et al.  Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon , 2012, Biological chemistry.

[21]  M. Prata,et al.  A shortcut to the lysosome: the mannose-6-phosphate-independent pathway. , 2012, Molecular genetics and metabolism.

[22]  Takako Sasaki,et al.  Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners , 2012, PloS one.

[23]  G. Bix,et al.  Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis? , 2012, Front. Pharmacol..

[24]  C. Peters,et al.  Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment , 2012, Inflammation Research.

[25]  D. Zukor,et al.  Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage , 2012, Arthritis Research & Therapy.

[26]  D. Turk,et al.  Protease signalling: the cutting edge , 2012, The EMBO journal.

[27]  K. Okumura,et al.  Role for Cysteine Protease Cathepsins in Heart Disease: Focus on Biology and Mechanisms With Clinical Implication , 2012, Circulation.

[28]  A. Bradshaw.  Diverse biological functions of the SPARC family of proteins. , 2012, The international journal of biochemistry & cell biology.

[29]  G. Bix,et al.  Oxygen–glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons , 2012, Brain Research.

[30]  X. Cheng,et al.  Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis. , 2012, Arthritis and rheumatism.

[31]  P. Libby,et al.  Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[32]  M. Bogyo,et al.  Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. , 2011, Current opinion in chemical biology.

[33]  E. Brogi,et al.  Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. , 2011, Genes & development.

[34]  K. Okumura,et al.  Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications. , 2011, Hypertension.

[35]  Z. Werb,et al.  Extracellular matrix degradation and remodeling in development and disease. , 2011, Cold Spring Harbor perspectives in biology.

[36]  Alex Bateman,et al.  MEROPS: the database of proteolytic enzymes, their substrates and inhibitors , 2011, Nucleic Acids Res..

[37]  Dipali Sharma,et al.  Anti-cancer role of SPARC, an inhibitor of adipogenesis. , 2011, Cancer treatment reviews.

[38]  O. Schilling,et al.  Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. , 2011, Journal of proteome research.

[39]  Olga Vasiljeva,et al.  Cysteine cathepsins: From structure, function and regulation to new frontiers☆ , 2011, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

[40]  Ludovic C. Gillet,et al.  Cysteine Cathepsins S and L Modulate Anti-angiogenic Activities of Human Endostatin* , 2011, The Journal of Biological Chemistry.

[41]  M. Goldring,et al.  Inflammation in osteoarthritis , 2011, Current opinion in rheumatology.

[42]  Christoph Peters,et al.  Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. , 2011, Nature nanotechnology.

[43]  M. Percival,et al.  Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. , 2011, Journal of autoimmunity.

[44]  J. Joyce,et al.  Proteolytic networks in cancer. , 2011, Trends in cell biology.

[45]  B. Turk,et al.  Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. , 2011, Bioorganic & medicinal chemistry.

[46]  Valerie M. Weaver,et al.  The extracellular matrix at a glance , 2010, Journal of Cell Science.

[47]  L. Holsinger,et al.  Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. , 2010, Biochimie.

[48]  T. Reinheckel,et al.  Specialized roles for cysteine cathepsins in health and disease. , 2010, The Journal of clinical investigation.

[49]  C. Peters,et al.  Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer , 2010, Biological chemistry.

[50]  M. Bogyo,et al.  Nuclear cysteine cathepsin variants in thyroid carcinoma cells , 2010, Biological chemistry.

[51]  M. Percival,et al.  Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice , 2010, Journal of cardiovascular pharmacology.

[52]  V. Turk,et al.  Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis , 2010, Biological chemistry.

[53]  D. DeSimone,et al.  The extracellular matrix in development and morphogenesis: a dynamic view. , 2010, Developmental biology.

[54]  C. Peters,et al.  Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis , 2010, Oncogene.

[55]  J. Joyce,et al.  IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. , 2010, Genes & development.

[56]  O. Vasiljeva,et al.  Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice , 2010, Proceedings of the National Academy of Sciences.

[57]  Bonnie F. Sloane,et al.  Interleukin-6 Increases Expression and Secretion of Cathepsin B by Breast Tumor-Associated Monocytes , 2010, Cellular Physiology and Biochemistry.

[58]  G. Karsenty,et al.  A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms , 2009, Molecular and Cellular Endocrinology.

[59]  J. Kos,et al.  Versatile Loops in Mycocypins Inhibit Three Protease Families* , 2009, Journal of Biological Chemistry.

[60]  O. Chinot,et al.  High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas , 2009, Acta Neuropathologica.

[61]  P. Saftig,et al.  Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function , 2009, Nature Reviews Molecular Cell Biology.

[62]  Bonnie F. Sloane,et al.  Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis. , 2009, The American journal of pathology.

[63]  M. Percival,et al.  Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools , 2009, Biological chemistry.

[64]  L. Duong,et al.  Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double‐Blind, Randomized, Placebo‐Controlled Phase I Studies , 2009, Clinical pharmacology and therapeutics.

[65]  L. Klareskog,et al.  Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice. , 2009, European journal of pharmacology.

[66]  C. Peters,et al.  Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases , 2009, Biological chemistry.

[67]  V. Turk,et al.  Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?* , 2009, The Journal of Biological Chemistry.

[68]  D. Brömme,et al.  Cathepsin K inhibitors for osteoporosis and potential off-target effects , 2009, Expert opinion on investigational drugs.

[69]  J. Kos,et al.  The role of cathepsin X in cell signaling , 2009, Cell adhesion & migration.

[70]  I. Podgorski.  Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis? , 2009, Future medicinal chemistry.

[71]  J. Pollard,et al.  Microenvironmental regulation of metastasis , 2009, Nature Reviews Cancer.

[72]  O. Vasiljeva,et al.  Autocatalytic processing of procathepsin B is triggered by proenzyme activity , 2009, The FEBS journal.

[73]  M. James,et al.  The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex. , 2008, Journal of molecular biology.

[74]  R. Iozzo,et al.  Diverse cell signaling events modulated by perlecan. , 2008, Biochemistry.

[75]  R. Paridaens,et al.  Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer. , 2008, The International journal of biological markers.

[76]  A. Pshezhetsky,et al.  Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis* , 2008, Journal of Biological Chemistry.

[77]  D. Brömme,et al.  Regulation of cathepsin K activity by hydrogen peroxide , 2008, Biological chemistry.

[78]  T. Welte,et al.  Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis , 2008, Respiratory research.

[79]  G. Salvesen,et al.  Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.

[80]  D. Zukor,et al.  Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage. , 2008, The American journal of pathology.

[81]  T. Peretz,et al.  Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment* , 2008, Journal of Biological Chemistry.

[82]  F. Veillard,et al.  Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system? , 2008, The international journal of biochemistry & cell biology.

[83]  D. Turk,et al.  Cystatins: biochemical and structural properties, and medical relevance. , 2008, Frontiers in bioscience : a journal and virtual library.

[84]  J. Kos,et al.  Cysteine protease cathepsin X modulates immune response via activation of β2 integrins , 2008, Immunology.

[85]  Gillian Murphy,et al.  Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? , 2008, Nature Clinical Practice Rheumatology.

[86]  C. F. van der Walle,et al.  A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation. , 2008, Biochemical and biophysical research communications.

[87]  K. Brix,et al.  Cysteine cathepsins: cellular roadmap to different functions. , 2008, Biochimie.

[88]  J. Falgueyret,et al.  The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. , 2008, Bioorganic & medicinal chemistry letters.

[89]  O. Vasiljeva,et al.  Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. , 2008, Biochimie.

[90]  B. Wiederanders,et al.  Cathepsins B, K, and L Are Regulated by a Defined Collagen Type II Peptide via Activation of Classical Protein Kinase C and p38 MAP Kinase in Articular Chondrocytes* , 2008, Journal of Biological Chemistry.

[91]  Raluca Ostafe,et al.  Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. , 2007, European journal of cell biology.

[92]  V. Turk,et al.  Glycosaminoglycans Facilitate Procathepsin B Activation through Disruption of Propeptide-Mature Enzyme Interactions* , 2007, Journal of Biological Chemistry.

[93]  Georges von Degenfeld,et al.  Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. , 2007, Nature chemical biology.

[94]  D. Hanahan,et al.  Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. , 2007, Cancer research.

[95]  Christoph Peters,et al.  Cathepsin L Deficiency Reduces Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Knockout Mice , 2007, Circulation.

[96]  E. Purisima,et al.  The S2 subsites of cathepsins K and L and their contribution to collagen degradation , 2007, Protein science : a publication of the Protein Society.

[97]  W. Stark,et al.  Interaction between Human Cathepsins K, L, and S and Elastins , 2007, Journal of Biological Chemistry.

[98]  Christopher M. Overall,et al.  In search of partners: linking extracellular proteases to substrates , 2007, Nature Reviews Molecular Cell Biology.

[99]  O. Vasiljeva,et al.  Emerging roles of cysteine cathepsins in disease and their potential as drug targets. , 2007, Current pharmaceutical design.

[100]  E. Vuorio,et al.  Role of cathepsin K in normal joints and in the development of arthritis. , 2007, Current drug targets.

[101]  J. Joyce,et al.  Cysteine Cathepsins and the Cutting Edge of Cancer Invasion , 2007, Cell cycle.

[102]  S. Zahler,et al.  RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties* , 2006, Journal of Biological Chemistry.

[103]  Bonnie F. Sloane,et al.  Cysteine cathepsins: multifunctional enzymes in cancer , 2006, Nature Reviews Cancer.

[104]  Karine Clément,et al.  Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation. , 2006, Endocrinology.

[105]  B. Turk.  Targeting proteases: successes, failures and future prospects , 2006, Nature Reviews Drug Discovery.

[106]  J. Kos,et al.  Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. , 2006, Experimental cell research.

[107]  O. Vasiljeva,et al.  Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. , 2006, Cancer research.

[108]  Francesco Leonetti,et al.  Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities* , 2006, Journal of Biological Chemistry.

[109]  B. Turk,et al.  Cysteine cathepsins in the immune response. , 2006, Tissue antigens.

[110]  R. Kalluri,et al.  Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors* , 2006, Journal of Biological Chemistry.

[111]  D. Hanahan,et al.  Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. , 2006, Genes & development.

[112]  P. Libby,et al.  Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. , 2006, Atherosclerosis.

[113]  M. Daemen,et al.  Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation , 2005, Circulation.

[114]  E. Vuorio,et al.  Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. , 2005, Arthritis and rheumatism.

[115]  J. Falgueyret,et al.  Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. , 2005, Journal of medicinal chemistry.

[116]  A. Rudensky,et al.  The lysosomal cysteine proteases in MHC class II antigen presentation , 2005, Immunological reviews.

[117]  T. Chambers,et al.  Recent developments in cathepsin K inhibitor design. , 2005, Current opinion in drug discovery & development.

[118]  D. Brömme,et al.  The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. , 2005, Advanced drug delivery reviews.

[119]  J. Kos,et al.  Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. , 2005, Experimental cell research.

[120]  L. Juliano,et al.  Cathepsin X binds to cell surface heparan sulfate proteoglycans. , 2005, Archives of biochemistry and biophysics.

[121]  Bonnie F. Sloane,et al.  Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. , 2005, Seminars in cancer biology.

[122]  Bonnie F. Sloane,et al.  Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells , 2005, Journal of Cell Science.

[123]  Bonnie F. Sloane,et al.  Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer. , 2005, Neoplasia.

[124]  O. Vasiljeva,et al.  Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans , 2005, FEBS letters.

[125]  A. Baici,et al.  Cathepsin B in osteoarthritis: uncontrolled proteolysis in the wrong place. , 2004, Seminars in arthritis and rheumatism.

[126]  Matthew Bogyo,et al.  Cathepsin V, a Novel and Potent Elastolytic Activity Expressed in Activated Macrophages* , 2004, Journal of Biological Chemistry.

[127]  R. Weissleder,et al.  In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. , 2004, Arthritis and rheumatism.

[128]  P. Libby,et al.  Lysosomal Cysteine Proteases in Atherosclerosis , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[129]  T. Welte,et al.  Pivotal role of cathepsin K in lung fibrosis. , 2004, The American journal of pathology.

[130]  Q. Deveraux,et al.  Comprehensive search for cysteine cathepsins in the human genome , 2004, Biological chemistry.

[131]  E. Vuorio,et al.  Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis , 2004, Annals of the rheumatic diseases.

[132]  D. Hanahan,et al.  Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. , 2004, Cancer cell.

[133]  M. Bogyo,et al.  A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. , 2004, Molecular cell.

[134]  M. Bogyo,et al.  Regulation of Collagenase Activities of Human Cathepsins by Glycosaminoglycans* , 2004, Journal of Biological Chemistry.

[135]  D. Brömme,et al.  Production and activation of recombinant papain-like cysteine proteases. , 2004, Methods.

[136]  O. Vasiljeva,et al.  Recombinant human cathepsin H lacking the mini chain is an endopeptidase. , 2003, Biochemistry.

[137]  M. Juliano,et al.  Probing cathepsin K activity with a selective substrate spanning its active site. , 2003, Biochemical Journal.

[138]  Bonnie F. Sloane,et al.  Cathepsin B and its role(s) in cancer progression. , 2003, Biochemical Society symposium.

[139]  Bonnie F. Sloane,et al.  Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. , 2003, Molecular imaging.

[140]  D. Brömme,et al.  Cleavage Site Specificity of Cathepsin K toward Cartilage Proteoglycans and Protease Complex Formation , 2003, Biological chemistry.

[141]  F. Gauthier,et al.  Procongopain from Trypanosoma congolense Is Processed at Basic pH: An Unusual Feature among Cathepsin L-Like Cysteine Proteases , 2003, Biological chemistry.

[142]  J. Deussing,et al.  Thyroid functions of mouse cathepsins B, K, and L. , 2003, The Journal of clinical investigation.

[143]  S. Goldring,et al.  Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. , 2003, Rheumatology.

[144]  Makoto Naito,et al.  Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. , 2003, The Journal of clinical investigation.

[145]  Kenneth M. Yamada,et al.  Fibronectin at a glance , 2002, Journal of Cell Science.

[146]  Bonnie F. Sloane,et al.  Degradation of Extracellular Matrix Protein Tenascin-C by Cathepsin B: An Interaction Involved in the Progression of Gliomas , 2002, Biological chemistry.

[147]  B. Gelb,et al.  Collagenase Activity of Cathepsin K Depends on Complex Formation with Chondroitin Sulfate* , 2002, The Journal of Biological Chemistry.

[148]  G. Salvesen,et al.  Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. , 2002, Current pharmaceutical design.

[149]  J. Kos,et al.  Lysosomal Enzymes, Cathepsins in Brain Tumour Invasion , 2002, Journal of Neuro-Oncology.

[150]  S. Santavirta,et al.  Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. , 2002, Arthritis and rheumatism.

[151]  S. Goldring,et al.  Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. , 2002, Arthritis and rheumatism.

[152]  S. Pervaiz,et al.  A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidification. , 2002, Biochemical and biophysical research communications.

[153]  A. Burlingame,et al.  Chemical Approaches for Functionally Probing the Proteome* , 2002, Molecular & Cellular Proteomics.

[154]  D Lamba,et al.  Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases , 2001, The EMBO journal.

[155]  R. Gordon,et al.  Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. , 2001, The American journal of pathology.

[156]  D. Turk,et al.  Lysosomal cysteine proteases: facts and opportunities , 2001, The EMBO journal.

[157]  E. Vuorio,et al.  Accelerated Turnover of Metaphyseal Trabecular Bone in Mice Overexpressing Cathepsin K , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[158]  I. James,et al.  Biosynthesis and processing of cathepsin K in cultured human osteoclasts. , 2001, Bone.

[159]  V. Turk,et al.  Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. , 2001, Biochemistry.

[160]  L. Juliano,et al.  Cathepsin B Activity Regulation , 2001, The Journal of Biological Chemistry.

[161]  V. Herzog,et al.  Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid , 2001, Biological chemistry.

[162]  Roger Y. Tsien,et al.  Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis , 2000, Nature Cell Biology.

[163]  Bonnie F. Sloane,et al.  Human Procathepsin B Interacts with the Annexin II Tetramer on the Surface of Tumor Cells* , 2000, The Journal of Biological Chemistry.

[164]  H. Ploegh,et al.  Secreted cathepsin L generates endostatin from collagen XVIII , 2000, The EMBO journal.

[165]  D. Turk,et al.  Lysosomal cysteine proteases: more than scavengers. , 2000, Biochimica et biophysica acta.

[166]  D. Turk,et al.  Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. , 2000, Structure.

[167]  J. Kos,et al.  Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking , 2000, British Journal of Cancer.

[168]  D. Brömme,et al.  Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates. , 2000, Biochemistry.

[169]  V. Turk,et al.  Autocatalytic processing of recombinant human procathepsin B is a bimolecular process , 1999, FEBS letters.

[170]  I. Kola,et al.  Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[171]  E. Purisima,et al.  Human cathepsin X: A cysteine protease with unique carboxypeptidase activity. , 1999, Biochemistry.

[172]  E. Mehler,et al.  Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. , 1999, Biochemistry.

[173]  P. Delmas,et al.  The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases* , 1998, The Journal of Biological Chemistry.

[174]  Sheila J. Jones,et al.  Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[175]  J. Mort,et al.  Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope. , 1998, Biochemical Journal.

[176]  J. Kos,et al.  Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). , 1998, Oncology reports.

[177]  P. Petrow,et al.  Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. , 1998, The Journal of rheumatology.

[178]  P. Libby,et al.  Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. , 1998, The Journal of clinical investigation.

[179]  R. Desnick,et al.  Genomic structure, chromosomal localization, and expression of human cathepsin W. , 1998, Biochemical and biophysical research communications.

[180]  A. Hollander,et al.  Molecular Interaction and Matrix Assembly , 1998, The Biochemical journal.

[181]  J. Kos,et al.  Cysteine proteinases in cancer progression and their clinical relevance for prognosis. , 1998, Biological chemistry.

[182]  D. Turk,et al.  Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function. , 1998, Structure.

[183]  Z. Werb.  ECM and Cell Surface Proteolysis: Regulating Cellular Ecology , 1997, Cell.

[184]  R. Ménard,et al.  Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. , 1997, Biochemistry.

[185]  D. Turk,et al.  Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen. , 1997, Journal of molecular biology.

[186]  G. Huet,et al.  Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells. , 1997, British journal of rheumatology.

[187]  R. Baumgrass,et al.  Identification of Peptide Fragments Generated by Digestion of Bovine and Human Osteocalcin with the Lysosomal Proteinases Cathepsin B, D, L, H, and S , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[188]  C. Debouck,et al.  Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*) , 1996, The Journal of Biological Chemistry.

[189]  D. Mcnulty,et al.  Proteolytic Activity of Human Osteoclast Cathepsin K , 1996, The Journal of Biological Chemistry.

[190]  D. Brömme,et al.  Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts , 1996, The Journal of Biological Chemistry.

[191]  E. Kominami,et al.  Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro. , 1995, Biochemical and biophysical research communications.

[192]  J. Kos,et al.  Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins. , 1995, Biological chemistry Hoppe-Seyler.

[193]  D. Turk,et al.  Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site. , 1994, Biochemistry.

[194]  H. Kobayashi,et al.  Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes. , 1993, Biochimica et biophysica acta.

[195]  T. Chambers,et al.  Degradation of bone matrix proteins by osteoclast cathepsins. , 1993, The International journal of biochemistry.

[196]  V. Turk,et al.  Kinetics of the pH-induced inactivation of human cathepsin L. , 1993, Biochemistry.

[197]  R. Mason,et al.  Surface activation of pro-cathepsin L. , 1992, Biochemical and biophysical research communications.

[198]  T. Hardingham,et al.  The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. , 1992, The Journal of biological chemistry.

[199]  Bonnie F. Sloane,et al.  Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues. , 1992, The Biochemical journal.

[200]  Robert Huber,et al.  The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity. , 1991, The EMBO journal.

[201]  H. Kirschke,et al.  Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. , 1989, The Biochemical journal.

[202]  Bonnie F. Sloane,et al.  Membrane-associated cathepsin L: a role in metastasis of melanomas. , 1989, Biochemical and biophysical research communications.

[203]  J. Peter-Katalinic,et al.  Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases. , 1988 .

[204]  R. Maciewicz,et al.  Collagenolytic cathepsins of rabbit spleen: a kinetic analysis of collagen degradation and inhibition by chicken cystatin. , 1987, Collagen and related research.

[205]  Bonnie F. Sloane,et al.  Cathepsin B: association with plasma membrane in metastatic tumors. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[206]  A. Poole,et al.  Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH. , 1984, Arthritis and rheumatism.

[207]  Bonnie F. Sloane,et al.  Lysosomal cathepsin B: correlation with metastatic potential. , 1981, Science.

[208]  A. Berger,et al.  On the size of the active site in proteases. I. Papain. , 1967, Biochemical and biophysical research communications.

[209]  G. Shi,et al.  Cysteine protease cathepsins and matrix metalloproteinases in the development of abdominal aortic aneurysms. , 2013, Future cardiology.

[210]  B. Turk,et al.  The endolysosomal system in cell death and survival. , 2013, Cold Spring Harbor perspectives in biology.

[211]  D. Brömme,et al.  Role of Cysteine Cathepsins in Extracellular Proteolysis , 2011 .

[212]  K. McCoy,et al.  Cytokines regulate cysteine cathepsins during TLR responses. , 2011, Cellular immunology.

[213]  BMC Biochemistry BioMed Central , 2009 .

[214]  Sanjay Kumar,et al.  6. Cathepsin K inhibitors: their potential as anti-osteoporosis agents. , 2004, Progress in medicinal chemistry.

[215]  J R Griffiths,et al.  Causes and consequences of tumour acidity and implications for treatment. , 2000, Molecular medicine today.

[216]  B. Bresnihan,et al.  Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. , 1999, Rheumatology.

[217]  D. Turk,et al.  Revised Definition of Substrate Binding Sites of Papain-Like Cysteine Proteases , 1998, Biological chemistry.

[218]  V. Turk,et al.  Determination of Cathepsins B and H in Sera and Synovial Fluids of Patients with Different Joint Diseases , 1990, Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.