The emergence of bovine spongiform encephalopathy and related diseases.

Since 1986, approximately 170,000 cases of bovine spongiform encephalopathy (BSE) have occurred among approximately one million animals infected by contaminated feed in the United Kingdom. A ruminant feed ban in 1988 resulted in the rapid decline of the epidemic. Transmissible spongiform encephalopathies due to agents indistinguishable from BSE have appeared in small numbers of exotic zoo animals; a small outbreak among domestic cats is declining. Creutzfeldt-Jakob disease (CJD) has been intensively monitored since 1990 because of the risk BSE could pose to public health. In 1995, two adolescents in the United Kingdom died of CJD, and through the early part of 1996, other relatively young people had cases of what became known as new variant CJD, whose transmissible agent (indistinguishable from that of BSE) is responsible for 26 cases in the United Kingdom and one in France. Areas of concern include how many cases will appear in the future and whether or not use of human blood and blood products may cause a second cycle of human infections.

[1]  S. Cousens,et al.  Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent , 1997, Nature.

[2]  M. Zeidler,et al.  New variant Creutzfeldt-Jakob disease: neurological features and diagnostic tests , 1997, The Lancet.

[3]  C. Donnelly,et al.  Transmission dynamics and epidemiology of BSE in British cattle , 1997, Nature.

[4]  R. G. Will,et al.  Predicting the CJD epidemic in humans , 1997, Nature.

[5]  J. Collinge,et al.  Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy , 1997, The Lancet.

[6]  Andrew F. Hill,et al.  Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD , 1996, Nature.

[7]  M. Nowak,et al.  Prediction of future BSE spread , 1996, Nature.

[8]  A. Hofman,et al.  A new variant of Creutzfeldt-Jakob disease in the UK , 1996, The Lancet.

[9]  J. Ryan,et al.  Bovine spongiform encephalopathy: aspects of the clinical picture and analyses of possible changes 1986-1990 , 1992, Veterinary Record.

[10]  M. Dawson,et al.  Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle , 1990, Veterinary Record.

[11]  J. Ryan,et al.  Bovine spongiform encephalopathy: epidemiological studies , 1988, Veterinary Record.

[12]  H. Fraser,et al.  Transmission of bovine spongiform encephalopathy to mice , 1988, Veterinary Record.

[13]  M. Jeffrey,et al.  A novel progressive spongiform encephalopathy in cattle , 1987, Veterinary Record.

[14]  Farm Buildings,et al.  Ministry of Agriculture, Fisheries and Food- , 1956 .

[15]  Christl A. Donnelly,et al.  Analysis of the Bovine Spongiform Encephalopathy Maternal Cohort Study: Evidence for Direct Maternal Transmission , 1997 .