Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.

[1]  J. Ilaš,et al.  3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function. , 2008, Journal of medicinal chemistry.

[2]  J. Hirsh,et al.  New antithrombotic drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). , 2008, Chest.

[3]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[4]  E. P. A. D. Hadjipavlou-Litina Lipoxygenases (LOs): An Heterogenous Family of Lipid Peroxidizing Enzymes Implicated in Cell Differentiation, Inflammation, Asthma, Carcinogenesis, Atherogenesis-An Interesting Target for the Development of Promising Drugs , 2005 .

[5]  R. Morphy,et al.  Designed multiple ligands. An emerging drug discovery paradigm. , 2005, Journal of medicinal chemistry.

[6]  V. Muzykantov,et al.  Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules. , 2005, Current pharmaceutical design.

[7]  Danijel Kikelj,et al.  Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities. , 2005, Journal of medicinal chemistry.

[8]  P. Gressens,et al.  Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies. , 2005, Journal of medicinal chemistry.

[9]  H. Kovacic,et al.  Integrins and coagulation: a role for ROS/redox signaling? , 2004, Antioxidants & redox signaling.

[10]  J. Girona,et al.  Aldehydes mediate tissue factor induction: A possible mechanism linking lipid peroxidation to thrombotic events , 2004, Journal of cellular physiology.

[11]  D. Hadjipavlou-Litina,et al.  Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents , 2003, Journal of enzyme inhibition and medicinal chemistry.

[12]  S. Collin,et al.  Measuring antioxidant efficiency of wort, malt, and hops against the 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. , 2000, Journal of agricultural and food chemistry.

[13]  B. Pfeiffer,et al.  Synthesis and in vitro evaluation of new 8-amino-1,4-benzoxazine derivatives as neuroprotective antioxidants. , 1999, Journal of medicinal chemistry.

[14]  P. Carmeliet,et al.  Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. , 1998, The Journal of clinical investigation.

[15]  A. Beaudet,et al.  The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. , 1996, Journal of immunology.

[16]  B. D. Harris,et al.  Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1). , 1996, The Journal of organic chemistry.

[17]  D. Kikelj,et al.  A convenient synthesis of 3,4-dihydro-2-methyl-3-oxo-2H-1,4-benzoxazine-2-carboxylic acids and 3,4-dihydro-2-methyl-3-oxo-2H-pyrido[3,2-b]-1, 4-oxazine-2-carboxylic acid , 1993 .

[18]  J. Kauffman,et al.  Synthesis and structure-activity relationships of anti-inflammatory 9,10-dihydro-9-oxo-2-acridine-alkanoic acids and 4-(2-carboxyphenyl)aminobenzenealkanoic acids. , 1990, Journal of pharmaceutical sciences.

[19]  R. Schaub,et al.  Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor. , 1986, Experimental and molecular pathology.

[20]  O. Mitsunobu The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products , 1981 .

[21]  D. Neilson,et al.  The Chemistry of Imidates. , 1961 .

[22]  M. S. Blois,et al.  Antioxidant Determinations by the Use of a Stable Free Radical , 1958, Nature.

[23]  M. Hatmi,et al.  Prévention de la thrombose et de l'inflammation vasculaire : place des inhibiteurs mixtes des cyclooxygénases et de la 5-lipoxygénase , 2006 .

[24]  K. Müller 5‐Lipoxygenase and 12‐Lipoxygenase: Attractive Targets for the Development of Novel Antipsoriatic Drugs. 5‐Lipoxygenase und 12‐Lipoxygenase: Attraktive Target‐Enzyme für die Entwicklung neuer Antipsoriatika , 1994 .