Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.
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[1] J. Ilaš,et al. 3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function. , 2008, Journal of medicinal chemistry.
[2] J. Hirsh,et al. New antithrombotic drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). , 2008, Chest.
[3] Alan D. Lopez,et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.
[4] E. P. A. D. Hadjipavlou-Litina. Lipoxygenases (LOs): An Heterogenous Family of Lipid Peroxidizing Enzymes Implicated in Cell Differentiation, Inflammation, Asthma, Carcinogenesis, Atherogenesis-An Interesting Target for the Development of Promising Drugs , 2005 .
[5] R. Morphy,et al. Designed multiple ligands. An emerging drug discovery paradigm. , 2005, Journal of medicinal chemistry.
[6] V. Muzykantov,et al. Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules. , 2005, Current pharmaceutical design.
[7] Danijel Kikelj,et al. Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities. , 2005, Journal of medicinal chemistry.
[8] P. Gressens,et al. Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies. , 2005, Journal of medicinal chemistry.
[9] H. Kovacic,et al. Integrins and coagulation: a role for ROS/redox signaling? , 2004, Antioxidants & redox signaling.
[10] J. Girona,et al. Aldehydes mediate tissue factor induction: A possible mechanism linking lipid peroxidation to thrombotic events , 2004, Journal of cellular physiology.
[11] D. Hadjipavlou-Litina,et al. Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents , 2003, Journal of enzyme inhibition and medicinal chemistry.
[12] S. Collin,et al. Measuring antioxidant efficiency of wort, malt, and hops against the 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. , 2000, Journal of agricultural and food chemistry.
[13] B. Pfeiffer,et al. Synthesis and in vitro evaluation of new 8-amino-1,4-benzoxazine derivatives as neuroprotective antioxidants. , 1999, Journal of medicinal chemistry.
[14] P. Carmeliet,et al. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. , 1998, The Journal of clinical investigation.
[15] A. Beaudet,et al. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. , 1996, Journal of immunology.
[16] B. D. Harris,et al. Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1). , 1996, The Journal of organic chemistry.
[17] D. Kikelj,et al. A convenient synthesis of 3,4-dihydro-2-methyl-3-oxo-2H-1,4-benzoxazine-2-carboxylic acids and 3,4-dihydro-2-methyl-3-oxo-2H-pyrido[3,2-b]-1, 4-oxazine-2-carboxylic acid , 1993 .
[18] J. Kauffman,et al. Synthesis and structure-activity relationships of anti-inflammatory 9,10-dihydro-9-oxo-2-acridine-alkanoic acids and 4-(2-carboxyphenyl)aminobenzenealkanoic acids. , 1990, Journal of pharmaceutical sciences.
[19] R. Schaub,et al. Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor. , 1986, Experimental and molecular pathology.
[20] O. Mitsunobu. The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products , 1981 .
[21] D. Neilson,et al. The Chemistry of Imidates. , 1961 .
[22] M. S. Blois,et al. Antioxidant Determinations by the Use of a Stable Free Radical , 1958, Nature.
[23] M. Hatmi,et al. Prévention de la thrombose et de l'inflammation vasculaire : place des inhibiteurs mixtes des cyclooxygénases et de la 5-lipoxygénase , 2006 .
[24] K. Müller. 5‐Lipoxygenase and 12‐Lipoxygenase: Attractive Targets for the Development of Novel Antipsoriatic Drugs. 5‐Lipoxygenase und 12‐Lipoxygenase: Attraktive Target‐Enzyme für die Entwicklung neuer Antipsoriatika , 1994 .