Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome
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B. Tycko | N. Park | N. Schupf | J. Luchsinger | Joseph H. Lee | W. Silverman | L. Clark | S. Kisselev | S. Krinsky-McHale | D. Pang | W. Zigman | E. Jenkins | Lam-ha T. Dang | Annie J. Lee | Alexander Yale | David Kyung-Taek Oh
[1] A. Hofman,et al. A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly , 2014, Molecular Psychiatry.
[2] Matthew Schreiber,et al. Alzheimer’s Disease Genetics , 2014, Current Behavioral Neuroscience Reports.
[3] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[4] D. Harold,et al. Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome , 2013, Neurobiology of Aging.
[5] Jason J. Corneveaux,et al. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. , 2013, JAMA neurology.
[6] David A. Bennett,et al. The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers , 2013, PLoS genetics.
[7] Mark T. W. Ebbert,et al. Genetics of Alzheimer's Disease , 2013, BioMed research international.
[8] A. Attie,et al. Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide , 2013, The Journal of Neuroscience.
[9] J. Trojanowski,et al. Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker , 2013, Alzheimer's Research & Therapy.
[10] C. Jack,et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers , 2013, The Lancet Neurology.
[11] G. Kirov,et al. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk , 2012, Human molecular genetics.
[12] Lawrence Rajendran,et al. Role of genes linked to sporadic Alzheimer’s disease risk in the production of β-amyloid peptides , 2012, Proceedings of the National Academy of Sciences.
[13] L. Farrer,et al. Identification of Alzheimer disease-associated variants in genes that regulate retromer function , 2012, Neurobiology of Aging.
[14] A. Janssens,et al. Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome , 2012, Neurobiology of Aging.
[15] W. Silverman,et al. Aging and Down Syndrome , 2012, Current gerontology and geriatrics research.
[16] John Hardy,et al. The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE , 2012, Neurobiology of Aging.
[17] R. Mayeux,et al. Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels , 2012, Neurobiology of Aging.
[18] D. G. Clark,et al. Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease , 2011, Nature Genetics.
[19] Nick C Fox,et al. Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease , 2011, Nature Genetics.
[20] Sandro Sorbi,et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. , 2011, Archives of neurology.
[21] M. A. Kelly,et al. Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome , 2011, Neuroscience Letters.
[22] J. Haines,et al. SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk , 2011, Annals of neurology.
[23] K. Lunetta,et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. , 2010, Archives of neurology.
[24] S. Potkin,et al. Genome-wide association study of CSF biomarkers Aβ1-42, t-tau, and p-tau181p in the ADNI cohort , 2010, Neurology.
[25] R. Mayeux,et al. Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome , 2010, Neurology.
[26] K. Jellinger,et al. Plasma amyloid beta-42 independently predicts both late-onset depression and Alzheimer disease. , 2010, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
[27] Rudolph E Tanzi,et al. Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex , 2010, The Journal of Neuroscience.
[28] V. Pankratz,et al. Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease , 2010, PloS one.
[29] C. Ferrarese,et al. Increased Soluble APPα, Abeta 1-42, and Anti-Abeta 1-42 Antibodies in Plasma From Down Syndrome Patients , 2010, Alzheimer disease and associated disorders.
[30] A. Fagan,et al. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease , 2009, EMBO molecular medicine.
[31] M. Schulze,et al. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes , 2009, Journal of Molecular Medicine.
[32] M. Sano,et al. The Relationship of Plasma Aβ Levels to Dementia in Aging Individuals With Down Syndrome , 2009, Alzheimer disease and associated disorders.
[33] L. Kiemeney,et al. Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer , 2009, Nature Genetics.
[34] L. Buée,et al. Association of plasma amyloid β with risk of dementia , 2009, Neurology.
[35] Nick C Fox,et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes , 2009, Nature Genetics.
[36] P. Bosco,et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.
[37] J. Haines,et al. CALHM1 Polymorphism is not Associated with Late‐onset Alzheimer Disease , 2009, Annals of human genetics.
[38] S. DeKosky,et al. No association between CALHM1 variation and risk of Alzheimer disease , 2009, Human mutation.
[39] C. Ballard,et al. Amyloid β concentrations in older people with Down syndrome and dementia , 2009, Neuroscience Letters.
[40] J. Jia,et al. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease , 2009, Brain Research.
[41] D. Blacker,et al. No Association between CALHM1 and Alzheimer's Disease Risk , 2008, Cell.
[42] H. Fukuyama,et al. Peripheral Aβ subspecies as risk biomarkers of Alzheimer's disease , 2008, Proceedings of the National Academy of Sciences.
[43] F. Pasquier,et al. A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk , 2008, Cell.
[44] J. Jia,et al. Down‐regulation of insulin‐degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42 , 2008, The European journal of neuroscience.
[45] J. H. Kim,et al. Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population. , 2008, Diabetes research and clinical practice.
[46] N. Schupf,et al. Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome , 2007, Neuroscience Letters.
[47] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[48] R. Mayeux,et al. Elevated plasma amyloid β-peptide Aβ42, incident dementia and mortality in Down syndrome , 2007 .
[49] W. Markesbery,et al. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. , 2007, Archives of neurology.
[50] B. Yandell,et al. SORCS1: A Novel Human Type 2 Diabetes Susceptibility Gene Suggested by the Mouse , 2007, Diabetes.
[51] J. Buxbaum,et al. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease , 2007, Neurobiology of Aging.
[52] H. Soininen,et al. Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish population , 2007, Journal of Medical Genetics.
[53] Henrik Zetterberg,et al. Prediction of Alzheimer’s Disease Using the CSF Aβ42/Aβ40 Ratio in Patients with Mild Cognitive Impairment , 2007, Dementia and Geriatric Cognitive Disorders.
[54] A. Fagan,et al. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. , 2007, Archives of neurology.
[55] K. Lunetta,et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease , 2007, Nature Genetics.
[56] E. Head,et al. Beta-amyloid, oxidative stress and down syndrome. , 2006, Current Alzheimer research.
[57] S. DeKosky,et al. Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease , 2006, Neuroscience Letters.
[58] Philipp W. Raess,et al. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus , 2006, Nature Genetics.
[59] Pieter Visser,et al. Faculty Opinions recommendation of Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. , 2006 .
[60] M. Folstein,et al. Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis , 2006, Neurobiology of Aging.
[61] J. Sidtis,et al. Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
[62] Taylor J. Maxwell,et al. Association studies between risk for late‐onset Alzheimer's disease and variants in insulin degrading enzyme , 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[63] R. Mayeux,et al. Hyperinsulinemia and risk of Alzheimer disease , 2004, Neurology.
[64] C. Morris,et al. Influence of the amyloid precursor protein locus on dementia in Down syndrome , 2004, Neurology.
[65] N. Schupf,et al. Dementia in adults with mental retardation: assessment at a single point in time. , 2004, American journal of mental retardation : AJMR.
[66] Mitsutoshi Yamamoto,et al. No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[67] R. Mayeux,et al. Plasma A&bgr;40 and A&bgr;42 and Alzheimer’s disease: Relation to age, mortality, and risk , 2003 .
[68] K. Blennow,et al. CSF markers for incipient Alzheimer's disease , 2003, The Lancet Neurology.
[69] P. Wilson,et al. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. , 2003, Diabetes.
[70] M. McCarthy,et al. Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. , 2003, Diabetes.
[71] D. Campion,et al. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease , 2002, Neuroscience Letters.
[72] M. Owen,et al. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease , 2001, Human Genetics.
[73] Y. Benjamini,et al. THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .
[74] E. Head,et al. Down syndrome and Alzheimer's disease: a link between development and aging. , 2001, Mental retardation and developmental disabilities research reviews.
[75] B. Tycko,et al. Elevated plasma amyloid β-peptide 1–42 and onset of dementia in adults with Down syndrome , 2001, Neuroscience Letters.
[76] D. Selkoe. Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.
[77] H. Luthman,et al. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. , 2000, Human molecular genetics.
[78] E. Aylward,et al. Test battery for the diagnosis of dementia in individuals with intellectual disability. Working Group for the Establishment of Criteria for the Diagnosis of Dementia in Individuals with Intellectual Disability. , 2000, Journal of intellectual disability research : JIDR.
[79] K. Davis,et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. , 2000, JAMA.
[80] H. Wiśniewski,et al. Plasma amyloid β‐peptide 1–42 and incipient Alzheimer's disease , 1999 .
[81] B. Bogerts,et al. Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques , 1999, Neuroscience Letters.
[82] H. Wiśniewski,et al. Increased plasma amyloid β protein 1–42 levels in Down syndrome , 1998, Neuroscience Letters.
[83] E. Aylward,et al. Diagnosis of dementia in individuals with intellectual disability. , 1997, Journal of intellectual disability research : JIDR.
[84] T. Tokuda,et al. Plasma Levels of amyloid β proteins Aβ1–40 and Aβ1–42(43) are elevated in Down's syndrome , 1997 .
[85] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[86] Brian J Cummings,et al. Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity , 1995, The Lancet.
[87] D. Price,et al. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. , 1995, The American journal of pathology.
[88] I. Kurochkin,et al. Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme , 1994, FEBS letters.
[89] V. Prasher,et al. Down's syndrome, dementia, and superoxide dismutase , 1993, British Journal of Psychiatry.
[90] G. Reynolds,et al. Free radical damage in Down's syndrome brain. , 1993, Biochemical Society transactions.
[91] M. Pericak-Vance,et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.
[92] D. T. Vernier,et al. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. , 1990, Journal of lipid research.
[93] Z. Walker,et al. Oxidative stress and memory decline in adults with Down syndrome: longitudinal study. , 2012, Journal of Alzheimer's disease : JAD.
[94] F. Schmitt,et al. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. , 2011, Journal of Alzheimer's disease : JAD.
[95] G. H. Sergievsky. Type 2 Diabetes and Late-Onset Alzheimer ’ s Disease , 2011 .
[96] A. Ruiz,et al. CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model. , 2010, Journal of Alzheimer's disease : JAD.
[97] P. Bosco,et al. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. , 2010, Journal of Alzheimer's disease : JAD.
[98] S. Love,et al. ACE variants and association with brain Aβ levels in Alzheimer's disease. , 2010, American journal of translational research.
[99] P. D. de Bakker. Selection and evaluation of Tag-SNPs using Tagger and HapMap. , 2009, Cold Spring Harbor protocols.
[100] T. Uema,et al. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. , 2007, Human molecular genetics.
[101] R. Mayeux,et al. Incident Dementia, and Mortality in Down Syndrome , 2007 .
[102] M. McCarthy,et al. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. , 2006, Diabetes.
[103] BMC Endocrine Disorders BioMed Central , 2005 .
[104] G. Schellenberg,et al. Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele , 2003 .
[105] K. Kovacina,et al. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. , 2003, The American journal of pathology.
[106] L S Honig,et al. Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. , 2003, Neurology.
[107] S A Small,et al. Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. , 1999, Annals of neurology.
[108] H. Wiśniewski,et al. Increased plasma amyloid beta protein 1-42 levels in Down syndrome. , 1998, Neuroscience letters.
[109] S. Younkin,et al. The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer’s Disease Increase the Extracellular Concentration of Aβ1–42(43) , 1998 .
[110] T. Tokuda,et al. Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome. , 1997, Annals of neurology.
[111] S. Younkin. [The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43)]. , 1997, Rinsho shinkeigaku = Clinical neurology.
[112] D. Mann,et al. Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome , 1996, Nature Medicine.
[113] J. Hardy,et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. , 1996, Nature medicine.
[114] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .