Intermuscular adipose tissue (IMAT): Association with other adipose tissue compartments and insulin sensitivity

To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined.

[1]  F. Schick,et al.  Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction , 2008, Diabetologia.

[2]  B. Goodpaster,et al.  Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. , 2000, The American journal of clinical nutrition.

[3]  Stanley Heshka,et al.  Estimating whole‐body intermuscular adipose tissue from single cross‐sectional magnetic resonance images , 2006, Journal of applied physiology.

[4]  F. Schick,et al.  Standardized assessment of whole body adipose tissue topography by MRI , 2005, Journal of magnetic resonance imaging : JMRI.

[5]  B. Nicklas,et al.  Racial differences in insulin resistance and mid-thigh fat deposition in postmenopausal women. , 2002, Obesity research.

[6]  F. Schick,et al.  Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. , 1999, Diabetes.

[7]  S. Heymsfield,et al.  Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women. , 2004, The American journal of clinical nutrition.

[8]  F Schick,et al.  Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue , 1993, Magnetic resonance in medicine.

[9]  G. Bray,et al.  Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. , 2001, Metabolism: clinical and experimental.

[10]  Kohjiro Ueki,et al.  Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. , 2006, The Journal of clinical investigation.

[11]  C. D. Claussen,et al.  Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI / MRS study , 2005, Magnetic Resonance Materials in Physics, Biology and Medicine.

[12]  S. Kahn,et al.  Mechanisms linking obesity to insulin resistance and type 2 diabetes , 2006, Nature.

[13]  Stanley Heshka,et al.  Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. , 2005, The American journal of clinical nutrition.

[14]  C. Stehouwer,et al.  “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease , 2005, The Lancet.

[15]  Simon C Watkins,et al.  Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. , 2001, The Journal of clinical endocrinology and metabolism.

[16]  J. Gómez-Reino,et al.  The emerging role of adipokines as mediators of inflammation and immune responses. , 2007, Cytokine & growth factor reviews.

[17]  F. Schick,et al.  Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. , 2003, The Journal of clinical endocrinology and metabolism.

[18]  L. Rossetti,et al.  Mechanisms of fatty acid-induced inhibition of glucose uptake. , 1994, The Journal of clinical investigation.

[19]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[20]  D. Graveron-Demilly,et al.  Java-based graphical user interface for the MRUI quantitation package , 2001, Magnetic Resonance Materials in Physics, Biology and Medicine.

[21]  Vanhamme,et al.  Improved method for accurate and efficient quantification of MRS data with use of prior knowledge , 1997, Journal of magnetic resonance.

[22]  B. Goodpaster,et al.  Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat , 1997, Diabetes.

[23]  B. Nicklas,et al.  Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors , 1999, International Journal of Obesity.

[24]  R. Ross,et al.  Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. , 2002, Diabetes care.

[25]  F. Schick,et al.  Intramyocellular lipids and insulin resistance , 2004, Diabetes, obesity & metabolism.

[26]  Fritz Schick,et al.  Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects. , 2004, Diabetes care.

[27]  S. Kritchevsky,et al.  Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. , 2003, Diabetes care.

[28]  Tamara B Harris,et al.  Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. , 2005, Archives of internal medicine.

[29]  F. Schick,et al.  Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. , 1999, American journal of physiology. Endocrinology and metabolism.

[30]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[31]  C Boesch,et al.  In vivo determination of intra‐myocellular lipids in human muscle by means of localized 1H‐MR‐spectroscopy , 1997, Magnetic resonance in medicine.

[32]  Tamara B Harris,et al.  Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. , 2005, The American journal of clinical nutrition.

[33]  Després Jp.  Visceral obesity, insulin resistance, and dyslipidemia: contribution of endurance exercise training to the treatment of the plurimetabolic syndrome. , 1997 .

[34]  Lifestyle interventions to prevent type 2 diabetes , 2006, The Lancet.

[35]  S. Chew,et al.  The relationship between insulin resistance and cardiovascular risk factors in overweight/obese non-diabetic Asian adults: the 1992 Singapore National Health Survey , 2002, International Journal of Obesity.

[36]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[37]  Visceral adipose tissue as an indicator of insulin resistance in nonobese patients with new onset type 2 diabetes mellitus. , 2006, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[38]  G M Steil,et al.  Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. , 1996, The Journal of clinical investigation.

[39]  A. Baron,et al.  Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. , 1995, The Journal of clinical investigation.