Problem solving skills and concept mastery are the most essential skills in the 21st century. In relation to that, the purpose of this research is to develop a learning model, namely Karmana-Problem Based Learning (K-PBL) model to train the problem solving skills and concept mastery of biology teacher candidates. This is a research and development by using the Borg and Gall model design, which will produce a product, that is the K-PBL model is valid, practical, and effective. The validity of the model is assessed by validator, practicality is assessed using observation sheet of learning scenario and students activities,and the effectiveness is determined based on pre-test and post-test problem solving skills and biology concept mastery. The data technique analysis is descriptive-qualitative.The results of this resarch show that the developed learning model (K-PBL) is determined to be valid by the validator with a reliability score of 0,91 (reliable) with the syntax assessment: 1) Knowledge; 2) Advance organizer; 3) Review; 4) Management strategy; 5) Acting; 6) Note and presentation; and 7) Asessessment, including learning tools and instruments have been declared valid. Furthermore, the implementation of the learning model (try out) in biology education students of IKIP Mataram is declared to be practical because the percentage of learning implementation reaches 100% with reliability 0,97 (reliable), and the percentage of student activity also reach 100% with reliability 0,98 (reliable). In addition, the obstacles in learning that arise can be overcome. The model was also declared effective due to an increase in problem solving skills with a high grade 0.71 N-Gain score, concept mastery of the students achieve a high grade 0.73 N-Gain score with students responses to K-PBL model categorized positively (91,7%). It can be concluded the K-PBL model is valid, practical, and effective to train problem solving skills and concept mastery of biology teacher candidates.
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