Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

[1]  J. McCarthy,et al.  Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies , 2021, Malaria journal.

[2]  E. Bunnik,et al.  Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria , 2020, Frontiers in Immunology.

[3]  J. McCarthy,et al.  Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia , 2020, PLoS medicine.

[4]  P. Duffy,et al.  Malaria vaccines since 2000: progress, priorities, products , 2020, npj Vaccines.

[5]  L. Coffeng,et al.  An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria , 2020, Science Translational Medicine.

[6]  S. Hoffman,et al.  A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1 , 2020, Science Translational Medicine.

[7]  J. McCarthy,et al.  A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  L. Tilley,et al.  Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking , 2020, mBio.

[9]  J. McCarthy,et al.  A Plasmodium vivax experimental human infection model for evaluating efficacy of interventions , 2020, The Journal of clinical investigation.

[10]  Versione,et al.  Common Terminology Criteria for Adverse Events , 2020, Definitions.

[11]  Joseph D. Smith,et al.  Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries , 2020, Science Advances.

[12]  J. Kublin,et al.  Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data from Malaria Volunteer Infection Studies , 2019, The Journal of infectious diseases.

[13]  J. McCarthy,et al.  A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers , 2019, Antimicrobial Agents and Chemotherapy.

[14]  R. Kumar,et al.  The regulation of CD4+ T cells during malaria , 2019, Immunological reviews.

[15]  J. McCarthy,et al.  IgM in human immunity to Plasmodium falciparum malaria , 2019, Science Advances.

[16]  J. McCarthy,et al.  DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum , 2019, Antimicrobial Agents and Chemotherapy.

[17]  J. McCarthy,et al.  An experimental human blood stage model for studying Plasmodium malariae infection. , 2019, The Journal of infectious diseases.

[18]  A. Craig,et al.  Cerebral malaria is associated with differential cytoadherence to brain endothelial cells , 2019, EMBO molecular medicine.

[19]  S. Hoffman,et al.  Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study , 2018, BMC Medicine.

[20]  J. McCarthy,et al.  A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial , 2018, Malaria Journal.

[21]  J. Rayner,et al.  Malaria Vaccines: Recent Advances and New Horizons , 2018, Cell host & microbe.

[22]  R. Price,et al.  The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes , 2018, PLoS biology.

[23]  J. McCarthy,et al.  Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection‡ , 2018, Clinical & translational immunology.

[24]  Publisher's Note , 2018, Anaesthesia.

[25]  Julie G. Burel,et al.  Dichotomous miR expression and immune responses following primary blood-stage malaria. , 2017, JCI insight.

[26]  J. McCarthy,et al.  Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study , 2017, The Lancet. Infectious diseases.

[27]  Daniel L. Cameron,et al.  GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly , 2017, bioRxiv.

[28]  J. Kublin,et al.  Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects , 2017, Science Translational Medicine.

[29]  Julie G. Burel,et al.  Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection , 2016, Cell reports.

[30]  J. McCarthy,et al.  Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers , 2016, The Journal of antimicrobial chemotherapy.

[31]  S. Hoffman,et al.  Mosquito Passage Dramatically Changes Var Gene Expression in Controlled Human Plasmodium Falciparum Infections Author Summary , 2022 .

[32]  M. Good,et al.  Whole organism blood stage vaccines against malaria. , 2015, Vaccine.

[33]  Pieter Wesseling,et al.  DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly , 2014, Genome research.

[34]  A. Craig,et al.  An Analysis of the Binding Characteristics of a Panel of Recently Selected ICAM-1 Binding Plasmodium falciparum Patient Isolates , 2014, PloS one.

[35]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[36]  Christopher A. Miller,et al.  VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. , 2012, Genome research.

[37]  E. R. James,et al.  Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity , 2011, Science.

[38]  J. McCarthy,et al.  A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs , 2011, PloS one.

[39]  H. Hakonarson,et al.  SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data , 2011, Nucleic acids research.

[40]  J. McCarthy,et al.  Whole parasite blood stage malaria vaccines: A convergence of evidence , 2010, Human vaccines.

[41]  Celine Carret,et al.  Ectopic Recombination of a Malaria var Gene during Mitosis Associated with an Altered var Switch Rate , 2009, Journal of molecular biology.

[42]  Eileen Kraemer,et al.  PlasmoDB: a functional genomic database for malaria parasites , 2008, Nucleic Acids Res..

[43]  A. Cowman,et al.  Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. , 2007, Cell host & microbe.

[44]  M. Frank,et al.  Variable switching rates of malaria virulence genes are associated with chromosomal position , 2007, Molecular microbiology.

[45]  M. Molyneux,et al.  Transcribed var Genes Associated with Placental Malaria in MalawianWomen , 2006, Infection and Immunity.

[46]  Joseph D. Smith,et al.  Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome , 2003, Molecular microbiology.

[47]  Stephen J Rogerson,et al.  Asexual blood stages of malaria antigens: cytoadherence. , 2002, Chemical immunology.

[48]  Yang,et al.  P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1 , 1997, Nature.

[49]  Mark E. Wickham,et al.  Targeted Gene Disruption Shows That Knobs Enable Malaria-Infected Red Cells to Cytoadhere under Physiological Shear Stress , 1997, Cell.

[50]  M. Alpers,et al.  Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria , 1995, Parasite immunology (Print).

[51]  X. Su,et al.  The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes , 1995, Cell.

[52]  R. Howard,et al.  Molecular studies related to the pathogenesis of cerebral malaria. , 1989, Blood.

[53]  E. Peterson,et al.  Pathogenicity, stability, and immunogenicity of a knobless clone of Plasmodium falciparum in Colombian owl monkeys , 1985, Infection and immunity.

[54]  D. Whiley,et al.  A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers. , 2011, Malaria journal.

[55]  M. Dembert Essential Malariology , 1982, The Yale Journal of Biology and Medicine.