New design for QCM sensors in liquids

The use of quartz-crystal microbalance (QCM) sensors in liquids for analytical purposes requires a well-designed transducer. Therefore a theoretical model is necessary to characterize the influence of liquid properties like density, viscosity, conductivity and dielectric behaviour. The high damping of the liquid loading results in a large loss of the quartz-crystal quality factor. Special electronics and a suitable sensor cell are necessary to obtain good frequency stability. The paper describes a new device based on an operational transconductance amplifier (OTA) with a very high bandwidth. Experimental results illustrate the ability of the sensor system to detect small amounts of special analytes in liquids.

[1]  J. Roederer,et al.  Microgravimetric immunoassay with piezoelectric crystals , 1983 .

[2]  Stephen J. Martin,et al.  Characterization of a quartz crystal microbalance with simultaneous mass and liquid loading , 1991 .

[3]  Peter Hauptmann,et al.  Quartz crystal microbalance sensor in liquids , 1994 .

[4]  E Tamiya,et al.  Piezoelectric crystal biosensor modified with protein A for determination of immunoglobulins. , 1987, Analytical chemistry.

[5]  V. M. Mecea,et al.  Loaded vibrating quartz sensors , 1994 .

[6]  J. Gordon,et al.  Frequency of a quartz microbalance in contact with liquid , 1985 .

[7]  P. Woias,et al.  A quartz crystal biosensor for measurement in liquids. , 1992, Biosensors & bioelectronics.

[8]  Y. Okahata,et al.  ABSORPTION BEHAVIORS OF SURFACTANT MOLECULES ON A LIPID-COATED QUARTZ-CRYSTAL MICROBALANCE. AN ALTERNATIVE TO EYE-IRRITANT TESTS , 1991 .

[9]  Yoshio Okahata,et al.  Hybridization of nucleic acids immobilized on a quartz crystal microbalance , 1992 .

[10]  Stanley Bruckenstein,et al.  Experimental aspects of use of the quartz crystal microbalance in solution , 1985 .

[11]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .

[12]  C. Barnes,et al.  Development of quartz crystal oscillators for under-liquid sensing , 1991 .

[13]  E. Benes,et al.  Improved quartz crystal microbalance technique , 1984 .

[14]  L. Pannell,et al.  Dehalogenation reactions in californium-252 plasma desorption mass spectrometry. , 1985, Analytical chemistry.

[15]  K. Kanazawa,et al.  Physical description of a viscoelastically loaded AT‐cut quartz resonator , 1990 .

[16]  E. Dalcanale,et al.  Selective detection of organic compounds by means of cavitand-coated QCM transducers , 1995 .

[17]  D. Buttry,et al.  Electrochemical applications of the quartz crystal microbalance , 1989 .

[18]  G. Sauerbrey Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .