Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment

The post‐charging antibacterial therapy is highly promising for treatment of Gram‐negative bacterial wound infections. However, the therapeutic efficacy of the current electrode materials is yet unsatisfactory due to their low charge storage capacity and limited reactive oxygen species (ROS) yields. Herein, the design of MnOOH decorated Co3O4 nanoneedles (MCO) with exceptional post‐charging antibacterial effect against Gram‐negative bacteria at a low charge voltage and their implementation as a robust antibacterial electrode for skin wound treatment are reported. Taking advantaging of the increased active sites and enhanced OH− adsorption capability, the charge storage capacity and ROS production of the MCO electrode are remarkably boosted. As a result, the MCO electrode after charging at an ultralow voltage of 1.4 V gives a 5.49 log and 5.82 log bacterial reduction in Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) within an incubation time of only 5 min, respectively. More importantly, the antibacterial efficiency of the MCO electrode against multi‐drug resistant (MDR) bacteria including Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) also reaches 99.999%. In addition, the MCO electrode exhibits excellent reusability, and the role of extracellular ROS in enhancing post‐charging antibacterial activity is also unraveled.

[1]  J. Olowoyo,et al.  Recent Progress on Bimetallic-Based Spinels as Electrocatalysts for the Oxygen Evolution Reaction. , 2022, Small.

[2]  Chia-Hung Chen,et al.  Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection , 2022, Nature Communications.

[3]  Haihua Xiao,et al.  Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy , 2022, Advanced science.

[4]  Fangfu Ye,et al.  Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing , 2022, Advanced science.

[5]  Shiwei Lin,et al.  Tuning the Interfacial Electronic Coupling of NiO via CeO2 and nitrogen co-decoration for highly efficient oxygen evolution reaction , 2021, Chemical Engineering Journal.

[6]  Yi Yan Yang,et al.  Antimicrobial Polypeptides Capable of Membrane Translocation for Treatment of MRSA Wound Infection In Vivo , 2021, Advanced healthcare materials.

[7]  Y. Mou,et al.  Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections , 2021, Nature Communications.

[8]  Yi Yan Yang,et al.  Co3O4 Nanowires Capable of Discharging Low Voltage Electricity Showing Potent Antibacterial Activity for Treatment of Bacterial Skin Infection , 2021, Advanced Healthcare Materials.

[9]  Y. Duan,et al.  Infection microenvironment-related antibacterial nanotherapeutic strategies. , 2021, Biomaterials.

[10]  D. Barreca,et al.  Plasma‐Assisted Synthesis of Co3O4‐Based Electrocatalysts on Ni Foam Substrates for the Oxygen Evolution Reaction , 2021, Advanced Materials Interfaces.

[11]  Lei Wang,et al.  Precise Molecular Engineering of Type I Photosensitizers with Near‐Infrared Aggregation‐Induced Emission for Image‐Guided Photodynamic Killing of Multidrug‐Resistant Bacteria , 2021, Advanced science.

[12]  Jianlin Shi,et al.  MnO2 Electrocatalysts Coordinating Alcohol Oxidation for Ultra-durable Hydrogen and Chemical Productions in Acidic Solutions. , 2021, Angewandte Chemie.

[13]  Yi Yan Yang,et al.  Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo , 2021, Advanced Functional Materials.

[14]  Jianliang Shen,et al.  Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing , 2021, Bioactive materials.

[15]  Kai Yang,et al.  Kinetically Controlled, Scalable Synthesis of γ‐FeOOH Nanosheet Arrays on Nickel Foam toward Efficient Oxygen Evolution: The Key Role of In‐Situ‐Generated γ‐NiOOH , 2021, Advanced materials.

[16]  Qingliang Liao,et al.  A‐Site Management Prompts the Dynamic Reconstructed Active Phase of Perovskite Oxide OER Catalysts , 2021, Advanced Energy Materials.

[17]  W. Tian,et al.  An effective self-powered strategy to endow titanium implant surface with associated activity of anti-biofilm and osteogenesis , 2020 .

[18]  V. Rotello,et al.  Functionalized Polymers Enhance Permeability of Antibiotics in Gram‐Negative MDR Bacteria and Biofilms for Synergistic Antimicrobial Therapy , 2020, Advanced therapeutics.

[19]  Shougang Chen,et al.  Hierarchical Cu2O nanowires covered by silver nanoparticles-doped carbon layer supported on Cu foam for rapid and efficient water disinfection with lower voltage , 2020 .

[20]  Yidan Zhang,et al.  Well-Defined Gold Nanorod/Polymer Hybrid Coating with Inherent Antifouling and Photothermal Bactericidal Properties for Treating Infected Hernia. , 2020, ACS nano.

[21]  J. Ji,et al.  Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms. , 2019, ACS nano.

[22]  Xiaoyuan Chen,et al.  Sono‐Immunotherapeutic Nanocapturer to Combat Multidrug‐Resistant Bacterial Infections , 2019, Advanced materials.

[23]  Yufeng Zheng,et al.  Eradicating Multidrug‐Resistant Bacteria Rapidly Using a Multi Functional g‐C3N4@ Bi2S3 Nanorod Heterojunction with or without Antibiotics , 2019, Advanced Functional Materials.

[24]  P. Chu,et al.  An antibacterial platform based on capacitive carbon-doped TiO2 nanotubes after direct or alternating current charging , 2018, Nature Communications.

[25]  Collins Wenhan Chu,et al.  A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset , 2018, Nature Communications.

[26]  Xuesi Chen,et al.  Antibacterial Hydrogels , 2018, Advanced science.

[27]  Geoffrey I N Waterhouse,et al.  Defect‐Engineered Ultrathin δ‐MnO2 Nanosheet Arrays as Bifunctional Electrodes for Efficient Overall Water Splitting , 2017 .

[28]  Zhong Lin Wang,et al.  A self-powered sterilization system with both instant and sustainable anti-bacterial ability , 2017 .

[29]  Robert J. Ono,et al.  Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity. , 2017, Biomaterials.

[30]  A. Manthiram,et al.  Design of a sectionalized MnO 2 -Co 3 O 4 electrode via selective electrodeposition of metal ions in hydrogel for enhanced electrocatalytic activity in metal-air batteries , 2016 .

[31]  P. Nagpal,et al.  Photoexcited quantum dots for killing multidrug-resistant bacteria. , 2016, Nature materials.

[32]  M. Willander,et al.  Self-powered electrochemical water treatment system for sterilization and algae removal using water wave energy , 2015 .

[33]  Yi Yan Yang,et al.  Broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. , 2015, Biomacromolecules.

[34]  Xing Xie,et al.  Static electricity powered copper oxide nanowire microbicidal electroporation for water disinfection. , 2014, Nano letters.

[35]  Yi Yan Yang,et al.  Block copolymer mixtures as antimicrobial hydrogels for biofilm eradication. , 2013, Biomaterials.

[36]  Lauren M. Sassoubre,et al.  Conducting nanosponge electroporation for affordable and high-efficiency disinfection of bacteria and viruses in water. , 2013, Nano letters.

[37]  S. Levy,et al.  Antibacterial resistance worldwide: causes, challenges and responses , 2004, Nature Medicine.

[38]  C. Walsh.  Molecular mechanisms that confer antibacterial drug resistance , 2000, Nature.

[39]  Robert Schlögl,et al.  Electrocatalytic Oxygen Evolution Reaction in Acidic Environments – Reaction Mechanisms and Catalysts , 2017 .

[40]  Y. Li,et al.  3D self-supported nanopine forest-like Co3O4@CoMoO4 core–shell architectures for high-energy solid state supercapacitors , 2016 .

[41]  Yi Yan Yang,et al.  Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles. , 2014, Biomaterials.