Part per trillion nitric oxide measurement by optical feedback cavity-enhanced absorption spectroscopy in the mid-infrared

While nitric oxide (NO) is being monitored in various fields of application, there is still a lack of available instruments at a sub-ppb level of sensitivity. We report on the first application of Optical Feedback Cavity-Enhanced Absorption Spectroscopy (OF-CEAS) to NO trace gas analysis, with a room-temperature quantum-cascade laser at 5.26 µm (1900.5 cm$$^{-1}$$-1). A detection limit of 60 ppt is reached in a single measurement performed in 140 ms. The stability of the instrument allows to average for 10 s down to 8.3 ppt, limited by drift of etalon fringes in the spectra. This work opens the path towards new applications notably in breath analysis and environment sciences.

[1]  Daniele Romanini,et al.  Comparison of optical-feedback cavity-enhanced absorption spectroscopy and gas chromatography for ground-based and airborne measurements of atmospheric CO concentration , 2017 .

[2]  T. Ryerson,et al.  Diode laser-based cavity ring-down instrument for NO 3 , N 2 O 5 , NO, NO 2 and O 3 from aircraft , 2011 .

[3]  Daniele Romanini,et al.  A water isotope (2H, 17O, and 18O) spectrometer based on optical feedback cavity-enhanced absorption for in situ airborne applications , 2006 .

[4]  Gerard Wysocki,et al.  Ultrasensitive detection of nitric oxide at 5.33 μm by using external cavity quantum cascade laser-based Faraday rotation spectroscopy , 2009, Proceedings of the National Academy of Sciences.

[5]  A. Orr-Ewing,et al.  A quantum cascade laser-based optical feedback cavity-enhanced absorption spectrometer for the simultaneous measurement of CH4 and N2O in air , 2011 .

[6]  T. Risby.  Critical issues for breath analysis , 2008 .

[7]  M. Carras,et al.  Optical-feedback cavity-enhanced absorption spectroscopy with a quantum-cascade laser yields the lowest formaldehyde detection limit , 2013, Applied Physics B.

[8]  Markus Amann,et al.  Regional and Global Emissions of Air Pollutants: Recent Trends and Future Scenarios , 2013 .

[9]  F. Capasso,et al.  Recent progress in quantum cascade lasers and applications , 2001 .

[10]  Daniele Romanini,et al.  Optical–feedback cavity–enhanced absorption: a compact spectrometer for real–time measurement of atmospheric methane , 2006 .

[11]  S. Borri,et al.  Saturated-absorption cavity ring-down spectroscopy. , 2009, Physical review letters.

[12]  N. Roxhed,et al.  An amperometric nitric oxide sensor with fast response and ppb-level concentration detection relevant to asthma monitoring , 2015 .

[13]  Selective measurements of NO, NO 2 and NO y in the free troposphere using quantum cascade laser spectroscopy , 2012 .

[14]  Roy M. Harrison,et al.  Analysis of the air pollution climate at a central urban background site , 2010 .

[15]  Barry Lefer,et al.  Unexpected high levels of NO observed at South Pole , 2001 .

[16]  Daniele Romanini,et al.  Fast, low-noise, mode-by-mode, cavity-enhanced absorption spectroscopy by diode-laser self-locking , 2005 .

[17]  Luca Ciaffoni,et al.  ICL-Based OF-CEAS: A Sensitive Tool for Analytical Chemistry. , 2017, Analytical chemistry.

[18]  Frans J. M. Harren,et al.  Quantum cascade laser-based sensor for detection of exhaled and biogenic nitric oxide , 2013 .

[19]  K. Steffen,et al.  Vertical fluxes of NOx, HONO, and HNO3 above the snowpack at Summit, Greenland , 2002 .

[20]  R L Guyer,et al.  The molecule of the year. , 1989 .

[21]  James M. Roberts,et al.  Trends in ozone, its precursors, and related secondary oxidation products in Los Angeles, California: A synthesis of measurements from 1960 to 2010 , 2013 .

[22]  David I. Rosen,et al.  Integrated cavity output spectroscopy measurements of NO levels in breath with a pulsed room-temperature QCL , 2005 .

[23]  Magdi Yacoub,et al.  Exhaled nitric oxide during lung transplantation , 1997, The Lancet.

[24]  Jin Kim,et al.  Optical-feedback cavity ring-down spectroscopy measurements of extinction by aerosol particles. , 2009, The journal of physical chemistry. A.

[25]  R. Harley,et al.  Modeling the weekly cycle of NOx and CO emissions and their impacts on O3 in the Los Angeles‐South Coast Air Basin during the CalNex 2010 field campaign , 2016 .

[26]  D. Romanini,et al.  Very high finesse optical-feedback cavity-enhanced absorption spectrometer for low concentration water vapor isotope analyses. , 2014, Optics letters.

[27]  W. Schade,et al.  QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells , 2014, Applied Physics B.

[28]  David D. Nelson,et al.  Evaluation of nitrogen dioxide chemiluminescence monitors in a polluted urban environment , 2007 .

[29]  C. Merlo,et al.  Serial monitoring of exhaled nitric oxide in lung transplant recipients. , 2015, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[30]  Chi-Yen Shen,et al.  Rayleigh surface acoustic wave sensor for ppb-level nitric oxide gas sensing , 2014 .

[31]  Thierry Gonthiez,et al.  Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy. , 2009, Journal of biomedical optics.

[32]  M. Nix,et al.  Optical feedback cavity-enhanced absorption spectroscopy (OF-CEAS) in a ring cavity , 2010 .

[33]  J. Szecsenyi,et al.  Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study , 2009, Respiratory research.

[34]  Daniele Romanini,et al.  Optical-feedback cavity-enhanced absorption spectroscopy with an interband cascade laser: application to SO2 trace analysis , 2016 .

[35]  W. Dubé,et al.  A sensitive and versatile detector for atmospheric NO2 and NOx based on blue diode laser cavity ring-down spectroscopy. , 2009, Environmental science & technology.

[36]  Grant A. D. Ritchie,et al.  Optical feedback cavity-enhanced absorption spectroscopy with a 3.24 μm interband cascade laser , 2015 .

[37]  M. Legrand,et al.  First investigations of IO, BrO, and NO2 summer atmospheric levels at a coastal East Antarctic site using mode‐locked cavity enhanced absorption spectroscopy , 2013 .

[38]  Paul B. Shepson,et al.  Air-Snow Interactions and Atmospheric Chemistry , 2002, Science.

[39]  F. Priolo,et al.  Nanoscale amorphization, bending and recrystallization in silicon nanowires , 2011 .

[40]  M. Carras,et al.  Optical-feedback cavity-enhanced absorption spectroscopy with a quantum cascade laser. , 2010, Optics letters.

[41]  J. V. van Amsterdam,et al.  Exhaled nitric oxide monitoring by quantum cascade laser: comparison with chemiluminescent and electrochemical sensors. , 2012, Journal of biomedical optics.

[42]  D. Romanini,et al.  A Microdrop Generator for the Calibration of a Water Vapor Isotope Ratio Spectrometer , 2009 .

[43]  Y. Rouillard,et al.  Looking into the volcano with a Mid-IR DFB diode laser and Cavity Enhanced Absorption Spectroscopy. , 2006, Optics express.

[44]  J. Galloway,et al.  A chronology of human understanding of the nitrogen cycle† , 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

[45]  M. Fraser,et al.  Application of quantum cascade lasers to trace gas analysis , 2008 .

[46]  D. Lenschow,et al.  Observations of summertime NO fluxes and boundary-layer height at the South Pole during ISCAT 2000 using scalar similarity , 2004 .

[47]  George B Hanna,et al.  Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise? , 2013, Journal of breath research.

[48]  Vincenzo Spagnolo,et al.  Ppb-level detection of nitric oxide using an external cavity quantum cascade laser based QEPAS sensor. , 2011, Optics express.