Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population‐based cohort study in the Netherlands

Background: Prenatal diagnosis of several major congenital anomalies can be achieved in the first trimester of pregnancy. Objective: This study investigates the timing of diagnosis and pregnancy outcome of foetuses and neonates with selected structural anomalies in the Northern Netherlands over a 10- year period when the prenatal screening programme changed significantly, but no first- trimester anatomical screening was implemented. Methods: We performed a population- based retrospective cohort study with data from the EUROCAT Northern Netherlands database on pregnancies with delivery or termination of pregnancy for fetal anomaly (TOPFA) date between 2010 and 2019. The analysis was restricted to anomalies potentially detectable in the first trimester of pregnancy in at least 50% of cases, based on previously published data. These included: anencephaly, encephalocele, spina bifida, holoprosencephaly, tricuspid/ pulmonary

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