The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells

Null mutations of glass specifically remove photo-receptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a single neuronal cell type.

[1]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[2]  A. Tomlinson.  The cellular dynamics of pattern formation in the eye of Drosophila. , 1985, Journal of embryology and experimental morphology.

[3]  H. Jäckle,et al.  Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA , 1986, Nature.

[4]  James W. Fristrom,et al.  Preparative isolation and short-term organ culture of imaginal discs ofDrosophila melanogaster , 1979 .

[5]  G. Rubin,et al.  The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head , 1988, Cell.

[6]  D. Ready,et al.  Cell fate in the Drosophila ommatidium. , 1987, Developmental biology.

[7]  Donald F. Ready,et al.  Building an Ommatidium: Geometry and Genes , 1986 .

[8]  T. Maniatis,et al.  Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Joel B. Sheffield,et al.  Development of Order in the Visual System , 1986, Cell and Developmental Biology of the Eye.

[10]  G. Rubin,et al.  Effects of genomic position on the expression of transduced copies of the white gene of Drosophila. , 1985, Science.

[11]  S. Benzer,et al.  Development of the Drosophila retina, a neurocrystalline lattice. , 1976, Developmental biology.

[12]  P. Lemaire,et al.  Characterization of a mouse multigene family that encodes zinc finger structures , 1988, Molecular and cellular biology.

[13]  R. Lehmann,et al.  Cross-regulatory interactions among the gap genes of Drosophila , 1986, Nature.

[14]  J. Messing.  [2] New M13 vectors for cloning , 1983 .

[15]  S. Benzer,et al.  Monoclonal antibodies against the Drosophila nervous system. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Bert Vogelstein,et al.  The GLI gene is a member of the Kruppel family of zinc finger proteins , 1988, Nature.

[17]  G. Rubin,et al.  Isolation and structure of a rhodopsin gene from D. melanogaster , 1985, Cell.

[18]  E. Meyerowitz,et al.  A genetic analysis of visual system development in Drosophilia melanogaster. , 1978, Developmental biology.

[19]  D. Hultmark,et al.  Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22 , 1986, Cell.

[20]  S. Zipursky,et al.  Analysis of mutants in chaoptin, a photoreceptor cell-specific glycoprotein in Drosophila, reveals its role in cellular morphogenesis , 1988, Cell.

[21]  M. Sanders.  Handbook of Sensory Physiology , 1975 .

[22]  G. Rubin,et al.  Rescue of the Drosophila phototransduction mutation trp by germline transformation. , 1985, Science.

[23]  D. Melton,et al.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. , 1984, Nucleic acids research.

[24]  M. Ciriacy.  Genetics of alcohol dehydrogenase in Saccharomyces cerevisiae. II. Two loci controlling synthesis of the glucose-repressible ADH II. , 1975, Molecular & general genetics : MGG.

[25]  D. Ready,et al.  Neuronal differentiation in Drosophila ommatidium. , 1987, Developmental biology.

[26]  H. Jäckle,et al.  A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene , 1986, Cell.

[27]  J. Sedat,et al.  Proteins shifting from the cytoplasm into the nuclei during early embryogenesis of Drosophila melanogaster. , 1984, Developmental biology.

[28]  Gerald M. Rubin,et al.  disconnected: A locus required for neuronal pathway formation in the visual system of drosophila , 1987, Cell.

[29]  G. Rubin,et al.  Genetic transformation of Drosophila with transposable element vectors. , 1982, Science.

[30]  Y. Jan,et al.  Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[31]  G. Rubin,et al.  rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye , 1988, Cell.

[32]  S. McKnight,et al.  Transcriptional control signals of a eukaryotic protein-coding gene. , 1982, Science.

[33]  P. Bingham,et al.  Molecular cloning of sequences from a drosophila RNA polymerase II locus by P element transposon tagging , 1982, Cell.

[34]  A Klug,et al.  Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes. , 1985, The EMBO journal.

[35]  D. Cavener,et al.  Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. , 1987, Nucleic acids research.

[36]  J. C. Hall,et al.  Behavior and cytogenetics of fruitless in Drosophila melanogaster: different courtship defects caused by separate, closely linked lesions. , 1989, Genetics.

[37]  A T Bankier,et al.  Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene. , 1988, The EMBO journal.

[38]  T. Morgan,et al.  The third-chromosome group of mutant characters of Drosophila melanogaster , 1923 .

[39]  E Seifert,et al.  Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulation , 1987, Cell.

[40]  G. Rubin,et al.  Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila , 1987, Cell.

[41]  Aaron Klug,et al.  ‘Zinc fingers’: a novel protein motif for nucleic acid recognition , 1987 .

[42]  Robert Tjian,et al.  Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain , 1987, Cell.

[43]  P. Lawrence,et al.  Cell lineage in the developing retina of Drosophila. , 1979, Developmental biology.