Role of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis delta

Immunohistochemical assessment of liver tissue in chronic delta hepatitis (CDH) is underinvestigated. Aim of the study was (i) to assess variables associated with hepatitis D antigen (HDAg), hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) staining in the liver.

[1]  M. Manns,et al.  46 LONG-TERM FOLLOW-UP AFTER PEG-IFNa2a-BASED THERAPY OF CHRONIC HEPATITIS DELTA , 2013 .

[2]  M. Manns,et al.  HBeAg‐positive hepatitis delta: virological patterns and clinical long‐term outcome , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[3]  M. Rizzetto Treatment of Chronic Delta Hepatitis , 2011, Hepatitis monthly.

[4]  R. Idilman,et al.  Natural history and treatment of chronic delta hepatitis , 2010, Journal of viral hepatitis.

[5]  A. Alibrandi,et al.  Replicative and Transcriptional Activities of Hepatitis B Virus in Patients Coinfected with Hepatitis B and Hepatitis Delta Viruses , 2010, Journal of Virology.

[6]  S. Lewin,et al.  Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers , 2010, Hepatology.

[7]  H. Wedemeyer,et al.  Hepatitis Delta: Immunopathogenesis and Clinical Challenges , 2010, Digestive Diseases.

[8]  M. Manns,et al.  Quantitative HBsAg and HDV‐RNA levels in chronic delta hepatitis , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[9]  C. Yurdaydın,et al.  Nuclear Localization of Hepatitis B Core Antigen and Its Relations to Liver Injury, Hepatocyte Proliferation, and Viral Load , 2003, Journal of clinical gastroenterology.

[10]  M. Manns,et al.  Famciclovir treatment of chronic delta hepatitis. , 2002, Journal of hepatology.

[11]  C. Seeger,et al.  Hepatitis B Virus Biology , 2000, Microbiology and Molecular Biology Reviews.

[12]  C. Chu,et al.  The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflect the level of viral replication in chronic hepatitis B virus infection , 1997, Journal of clinical microbiology.

[13]  S. Lemon,et al.  Subcellular distribution of large and small hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks , 1995, Hepatology.

[14]  K. Ishak,et al.  Histological grading and staging of chronic hepatitis. , 1995 .

[15]  J. Saldanha,et al.  Co‐expression of markers for hepatitis delta and hepatitis B viruses in human liver , 1992, Histopathology.

[16]  M. Rizzetto,et al.  Chronic hepatitis in carriers of hepatitis B surface antigen, with intrahepatic expression of the delta antigen. An active and progressive disease unresponsive to immunosuppressive treatment. , 1983, Annals of internal medicine.

[17]  R. Purcell,et al.  Transmission of the hepatitis B virus-associated delta antigen to chimpanzees. , 1980, The Journal of infectious diseases.

[18]  M. Rizzetto,et al.  Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. , 1977, Gut.

[19]  M. Manns,et al.  Pegylated interferon-based treatment in patients with advanced liver disease due to chronic delta hepatitis. , 2012, The Turkish Journal of Gastroenterology.

[20]  M. Manns,et al.  Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation. , 2012, Journal of hepatology.

[21]  D. Harnois Peginterferon plus Adefovir versus Either Drug Alone for Hepatitis Delta , 2011 .

[22]  M. Manns,et al.  Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead , 2010, Nature Reviews Gastroenterology &Hepatology.

[23]  M. Rizzetto,et al.  Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. , 1977, Gut.

[24]  C. Chu,et al.  Intrahepatic expression of hepatitis B core and surface antigens in chronic hepatitis delta-virus infection. , 1992, Journal of hepatology.

[25]  J. Hoofnagle,et al.  Intrahepatic markers of hepatitis delta virus infection: a study by in situ hybridization. , 1989, Hepatology.